Intermittent ketogenic diet promotes Treg differentiation and alleviates Crohn's disease via the β-hydroxybutyrate driven AHCY-DNMT1-Foxp3 axis [0.03%]
生酮饮食通过β-羟基丁酸激活的AHCY-DNMT1-Foxp3轴促进Treg细胞分化并缓解克罗恩病
Shaoqi Cheng,Chao Cheng,Chuanjiang Huang et al.
Shaoqi Cheng et al.
Background: Crohn's disease (CD) is characterized by epithelial barrier dysfunction and mucosal immune dysregulation. Dietary interventions have gained increasing attention as important therapeutic strategies. We evaluate...
Dysplasia in Pseudopolyps: Selection Bias, Reactive Atypia, and the Ulcer Paradox [0.03%]
伪息肉中的发育不良：选择偏差、反应性异型增生和溃疡悖论
Yusuf Bünyamin Ketencİ,Hakan Demiroz,Muge Ustaoğlu Dede
Yusuf Bünyamin Ketencİ
Quality metrics reflecting patient experience of GI endoscopy in Inflammatory Bowel Disease: results of national endoscopy dataset analysis [0.03%]
基于国家内镜数据库分析的炎症性肠病患者胃肠内镜检查体验质量指标的研究结果
Fiona Jones,Aonghus Lavelle,Finbar McCarthy et al.
Fiona Jones et al.
Introduction: ESGE have recently defined important performance measures for endoscopy in IBD. The role of patient experience in quality assessment of endoscopy in IBD is yet to be defined. We undertook an observational st...
Towards tailored surveillance strategies in inflammatory bowel disease: still a long way to go [0.03%]
炎症性肠病的个体化监测策略：仍有很长的路要走
José Luis Rueda García,Mark Löwenberg
José Luis Rueda García
Inflammatory Bowel Disease is associated with increased intestinal extrachromosomal circular DNA: an emerging biomarker for IBD type and activity [0.03%]
炎症性肠病与肠道细胞外染色体环状DNA增加有关：一种新兴的IBD类型和活动标志物
Valentina Petito,Daniela Gerovska,Antonia Piazzesi et al.
Valentina Petito et al.
Background and aims: Inflammatory Bowel Disease (IBD) is a gastrointestinal, auto-inflammatory disease with a chronic relapsing and remitting course, whose diagnosis is based on several exams assessing intestinal infiamma...
Treat-to-target optimization of biologic therapy is effective on endoscopic and histologic outcomes in a real-life cohort of ulcerative colitis-the TACTIC-UC study [0.03%]
基于目标的生物制剂治疗可改善溃疡性结肠炎患者的黏膜愈合：TACTIC-UC研究
Giuseppe Privitera,Cristina Bezzio,Arianna Dal Buono et al.
Giuseppe Privitera et al.
Background and aims: In ulcerative colitis (UC), therapeutic goals are evolving beyond symptom control toward endoscopic and histologic healing. However, optimal strategies to achieve these targets are undefined, and the ...
Intestinal Barrier healing is superior to transmural healing to prevent disease progession in clinical remittent patients with IBD [0.03%]
对于临床缓解期IBD患者的肠道屏障愈合优于全层愈合以防止疾病进展
Till Orlemann,Dana Zimmermann,Hannah Hübner et al.
Till Orlemann et al.
Background: Achieving endoscopic remission is a key therapeutic goal in IBD that is associated with improved disease outcome. Transmural and intestinal barrier healing represent emerging targets, as they have similarily b...
Research Progress on Exclusive Enteral Nutrition Combined with Biologics in the Treatment of Adult Crohn's Disease [0.03%]
生物制剂联合全肠内营养在成人克罗恩病中的研究进展
Libumu Axi,Yufang Wang,Wenjian Meng
Libumu Axi
Objective: To critically evaluate the evidence and mechanistic basis for combining exclusive enteral nutrition (EEN) with biologics in adults with Crohn's disease (CD), addressing the gap between strong theory and limited...
Correction to: Restoring Prostacyclin/PGI2-PTGIR signaling alleviates intestinal fibrosis in Crohn's disease via fibroblast-specific YAP/TAZ inhibition [0.03%]
Correction to: 恢复前列环素/PGI2-PTGIR信号通路通过成纤维细胞特异性抑制YAP/TAZ缓解克罗恩病肠纤维化
Published Erratum
Journal of Crohn's & colitis. 2025 Dec 23;19(12):jjaf142. DOI:10.1093/ecco-jcc/jjaf142 2025