Assessing the impact of delivery method on severe maternal morbidity among individuals with inflammatory bowel disease: a population-based study [0.03%]
基于人群的研究：评估分娩方式对炎症性肠病患者重度孕产妇发病的影响
Andrea N Simpson,Rinku Sutradhar,Eric I Benchimol et al.
Andrea N Simpson et al.
Background & aims: Individuals with inflammatory bowel disease (IBD) may have worse obstetrical outcomes than those without IBD. We assessed the odds of severe maternal morbidity (SMM) among individuals with IBD compared ...
Ustekinumab for ileal stricturing Crohn's disease-an international multicenter retrospective cohort study [0.03%]
ustekinumab治疗回肠狭窄型克罗恩病的多中心回顾队列研究
Sara El Ouali,Mark E Baker,Cathy Lu et al.
Sara El Ouali et al.
Background & aims: Stricturing Crohn's disease (CD) is a significant problem, and no selective anti-fibrotic therapies are available. Anti-inflammatory approaches are the mainstay of medical treatment. However, data on th...
Observational Study
Journal of Crohn's & colitis. 2026 Mar 10;20(3):jjag038. DOI:10.1093/ecco-jcc/jjag038 2026
Statin use is associated with lower rates of stricture development in patients with Crohn's disease: a propensity score-matched study of two nationwide population databases [0.03%]
他汀类药物使用与克罗恩病患者狭窄发生率降低有关：一项基于两个全国人群数据库的倾向性评分匹配研究
Abhishek Dimopoulos-Verma,Chiraag Kulkarni,C William Pike et al.
Abhishek Dimopoulos-Verma et al.
Background: Intestinal stricture affects over half of patients with Crohn's disease (CD) and has significant associated morbidity. Statins possess both anti-inflammatory and anti-fibrotic properties and may improve CD out...
Timing matters: recommendations for outcome assessment in real-world evidence studies of Crohn's disease [0.03%]
时机很重要：关于真实世界证据在克罗恩病研究中结局评估的建议
Paula Leão Moreira,Axel Dignass,Maria Manuela Estevinho et al.
Paula Leão Moreira et al.
Background: Real-world evidence (RWE) studies complement randomized trials by assessing treatment effectiveness and safety in routine clinical practice. In Crohn's disease (CD), heterogeneous disease progression makes sta...
Influence of vedolizumab on extraintestinal manifestations in inflammatory bowel disease: a nationwide multicenter study of the GETECCU ENEIDA Registry [0.03%]
维多珠单抗对炎症性肠病的肠外表现的影响：GETECCU ENEIDA注册中心全国多中心研究结果
Pablo Pérez-Galindo,Javier P Gisbert,Marta Carrillo-Palau et al.
Pablo Pérez-Galindo et al.
Background and aims: Evidence regarding the influence of vedolizumab (VDZ) on extraintestinal manifestations (EIMs) of inflammatory bowel disease (IBD) is limited. Our aim was to analyze the effectiveness of VDZ in preexi...
Observational Study
Journal of Crohn's & colitis. 2026 Mar 10;20(3):jjag024. DOI:10.1093/ecco-jcc/jjag024 2026
Transcriptomic profiling of fecal aspirates as a tool for prediction of endoscopic inflammation in small bowel Crohn's disease [0.03%]
粪便吸引物转录组分析在预测小肠克罗恩病内镜炎症中的应用
Tal Meningher,Orel Finkel,Omri Nayshool et al.
Tal Meningher et al.
Background and aims: While colonoscopy with mucosal biopsies remains the gold standard for evaluation and surveillance of Crohn's disease (CD), it does not allow a full evaluation of inflammation status over the entire sm...
Filgotinib treatment modulates frequency and gene expression of circulating immune cell subsets in ulcerative colitis [0.03%]
Filgotinib治疗可调节溃疡性结肠炎循环免疫细胞亚群的频率和基因表达
Emily R Wendt,Yan Liang,Grace Park et al.
Emily R Wendt et al.
Background and aims: Ulcerative colitis (UC) is a chronic inflammatory condition of the colon with heterogeneous patient responses to treatment. Janus kinase (JAK) inhibitors such as filgotinib reduce inflammation through...
Safety of advanced therapies in pregnant women with inflammatory bowel disease: a systematic review and Meta-Analysis [0.03%]
孕期炎症性肠病患者使用生物制剂和Janus激活剂的安全性：系统评价和Meta分析
Bernardo de Faria Moraes,Gustavo André Pedral Diniz Leite,Luisa Medeiros Visentini et al.
Bernardo de Faria Moraes et al.
Background & aims: The expanding use of advanced IBD therapies creates an urgent need for pregnancy safety data. While anti-TNF safety is well-established, evidence for newer agents (vedolizumab, ustekinumab, and JAK inhi...
Elena De Cristofaro,Irene Marafini,Giovanni Monteleone
Elena De Cristofaro