Bénédicte Caron,Ferdinando D&#x;Amico,Silvio Danese et al.
Bénédicte Caron et al.
Randomized clinical trials are the gold standard for the development of new drugs. Clinical trials have become increasingly complex, in particular in the field of inflammatory bowel diseases. For this reason, a new study design called 'clus...
T Cell Response After SARS-CoV-2 Vaccination in Immunocompromised Patients with Inflammatory Bowel Disease [0.03%]
炎症性肠病免疫抑制患者接种新型冠状病毒疫苗后的T细胞应答
P A Reuken,N Andreas,P C Grunert et al.
P A Reuken et al.
Background: Vaccination is a promising strategy to protect vulnerable groups like immunocompromised inflammatory bowel disease [IBD] patients from an infection with SARS-CoV-2. These patients may have lower immune respons...
The Phenotypic Spectrum of New-onset IBD in Canadian Children of South Asian Ethnicity: A Prospective Multi-Centre Comparative Study [0.03%]
加拿大南亚裔儿童新发炎症性肠病表型范围：一项前瞻性多中心比较研究
J Dhaliwal,M W Carroll,J C deBruyn et al.
J Dhaliwal et al.
Background: Canadian-born children of South Asian [SA] ethnicity develop inflammatory bowel disease [IBD] at similar rates to those among Caucasian children. We evaluated the variation in phenotypic spectrum of IBD in SA ...
Eileen Crowley,Christopher Ma,Marija Andic et al.
Eileen Crowley et al.
Background and aims: Timely access to approved medications is a priority in paediatric inflammatory bowel disease [IBD]. To date, the timing of drug studies in paediatric IBD has been suboptimal, with most studies conduct...
Non-autophagy Role of Atg5 and NBR1 in Unconventional Secretion of IL-12 Prevents Gut Dysbiosis and Inflammation [0.03%]
Atg5 和 NBR1 在分泌白细胞介素-12 的非自噬作用防止肠道菌群失调和炎症反应
Seth D Merkley,Samuel M Goodfellow,Yan Guo et al.
Seth D Merkley et al.
Intestinal myeloid cells play a critical role in balancing intestinal homeostasis and inflammation. Here, we report that expression of the autophagy-related 5 [Atg5] protein in myeloid cells prevents dysbiosis and excessive intestinal infla...
GATA6 Deficiency Leads to Epithelial Barrier Dysfunction and Enhances Susceptibility to Gut Inflammation [0.03%]
GATA6缺乏导致上皮屏障功能障碍并增加肠道炎症的易感性
Federica Laudisi,Carmine Stolfi,Gerolamo Bevivino et al.
Federica Laudisi et al.
Background and aims: Intestinal barrier dysfunction is a hallmark of inflammatory bowel diseases [IBD], but the mechanisms that lead to such a defect are not fully understood. This study was aimed at characterising the fa...
New Tools for Therapeutic Drug Monitoring: Making Big Things out of Small Pieces [0.03%]
治疗药物监测的新工具——化大为小的策略与应用
Erwin Dreesen
Erwin Dreesen
Identifying and Predicting the Goals and Concerns Prioritised by Individuals with Inflammatory Bowel Disease [0.03%]
识别和预测炎症性肠病患者优先考虑的目标和关注点
Chung Sang Tse,Aricca D Van Citters,Brittany Ricci et al.
Chung Sang Tse et al.
Background and aims: In order to provide high-quality care, providers need to understand their patients' goals and concerns. This study aims to identify and predict the goals and concerns prioritised by patients with infl...
ECCO Topical Review on Clinicopathological Spectrum and Differential Diagnosis of Inflammatory Bowel Disease [0.03%]
炎症性肠病的临床病理谱系及其鉴别诊断——ECCO专题评论
Roger Feakins,Joana Torres,Paula Borralho-Nunes et al.
Roger Feakins et al.
Introduction: Many diseases can imitate inflammatory bowel disease [IBD] clinically and pathologically. This review outlines the differential diagnosis of IBD and discusses morphological pointers and ancillary techniques ...
A Multidisciplinary Approach to Rectal Cancer Treatment in Ulcerative Colitis Results in High Rate of Restorative Minimally Invasive Surgery [0.03%]
溃疡性结肠炎合并结直肠癌的多学科综合治疗可实现高比率保肛微创手术
Michele Carvello,Vittoria Bellato,Annalisa Maroli et al.
Michele Carvello et al.
Background and aims: Few recent studies focus on the treatment of rectal cancer in patients with ulcerative colitis. We report treatment options and results for this subset of patients with a multimodal approach at two Eu...