Dual Roles for Endothelin-B Receptors in Modulating Adjuvant-Induced Inflammatory Hyperalgesia in Rats [0.03%]
内皮素受体B在调节大鼠佐剂性炎症痛觉过敏中发挥双重作用
Alla Khodorova,Shiping Zou,Ke Ren et al.
Alla Khodorova et al.
Injection of endothelin-1 (ET-1) into the plantar rat hindpaw causes acute pain at high concentrations and tactile sensitization at low concentrations. The pro-nociceptive actions are driven through ET(A) receptors for both levels of [ET-1]...
Microinjection of IL-1β into the trigeminal transition zone produces bilateral NMDA receptor-dependent orofacial hyperalgesia involving descending circuitry [0.03%]
注射IL-1β到三叉神经过渡区产生双侧NMDA受体依赖的口腔痛觉过敏涉及下行传导通路
K Shimizu,Bryan Chai,Stacey C Lagraize et al.
K Shimizu et al.
Our recent studies indicate that the prototypic proinflammatory cytokine IL-1β is upregulated in astroglial cells in the trigeminal interplolaris/caudalis (Vi/Vc) transition zone, a region of the spinal trigeminal complex involved in trige...
Tumor Necrosis Factor-α Suppresses Activation of Sustained Potassium Currents in Rat Small Diameter Sensory Neurons [0.03%]
肿瘤坏死因子α抑制大鼠小直径感觉神经元持续性钾电流的激活
Bao-Gang Liu,Maxim Dobretsov,Joseph R Stimers et al.
Bao-Gang Liu et al.
Tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine, produces pain and hyperalgesia by activating and/or sensitizing nociceptive sensory neurons. In the present study, using whole-cell patch clamp techniques, the regulation of po...
Ping-Heng Tan,Lin-Cheng Yang,Ru-Rong Ji
Ping-Heng Tan
In recent years RNA interference (RNAi) has rapidly become the most widely used tool for gene knockdown due to its high specificity and potency. RNAi is an evolutionarily conserved mechanism for silencing gene expression by targeted degrada...
c-Fos and pERK, which is a better marker for neuronal activation and central sensitization after noxious stimulation and tissue injury? [0.03%]
C- fos和perk哪个更好的标记noxious刺激和组织损伤后的神经元激活和中枢敏感化？
Yong-Jing Gao,Ru-Rong Ji
Yong-Jing Gao
c-Fos, the protein of the protooncogene c-fos, has been extensively used as a marker for the activation of nociceptive neurons in the spinal cord for more than twenty years since Hunt et al. first reported that peripheral noxious stimulatio...