A Mouse Model of Chronic Pancreatitis Induced by an Alcohol and High Fat Diet [0.03%]
酒精和高脂饮食诱导的慢性胰腺炎小鼠模型
T Clinkinbeard,R H Kline,L P Zhang et al.
T Clinkinbeard et al.
Background/aims: Study of acute pancreatitis in chemically-induced rodent models has provided useful data; models of alcoholic chronic pancreatitis have not been available in mice. The aim of the present study was to char...
David C Fritzinger,Daniel E Benjamin
David C Fritzinger
Certain types of pain are major unmet medical needs that affect more than 8 percent of the population. Neuropathic pain can be caused by many pathogenic processes including injury, autoimmune disease, neurological disease, endocrine dysfunc...
Resiniferatoxin for Pain Treatment: An Interventional Approach to Personalized Pain Medicine [0.03%]
雷公藤毒素痛治疗：个性化痛医学的介入方法
Michael J Iadarola,Gian Luigi Gonnella
Michael J Iadarola
This review examines existing preclinical and clinical studies related to resiniferatoxin (RTX) and its potential uses in pain treatment. Like capsaicin, RTX is a vanilloid receptor (TRPV1) agonist, only more potent. This increased potency ...
Susan M Huang,Man-Kyo Chung
Susan M Huang
Decades of characterization of the transient receptor potential vanilloid subtype 1 (TRPV1) has led to the realization of its central role in thermosensation and pain perception. A large number of pharmaceutical companies have had interest ...
The Qualitative Hyperalgesia Profile: A New Metric to Assess Chronic Post-Thoracotomy Pain [0.03%]
量化痛觉过敏表型：评估胸部手术后慢性疼痛的新指标
Jeffrey Chi-Fei Wang,Ching-Hsia Hung,Peter Gerner et al.
Jeffrey Chi-Fei Wang et al.
Thoracotomy often results in chronic pain, characterized by resting pain and elevated mechano-sensitivity. This paper defines complex behavioral responses to tactile stimulation in rats after thoracotomy, shown to be reversibly relieved by ...
Octavia Plesh,Stuart A Gansky,Donald A Curtis
Octavia Plesh
This is a longitudinal study of a large US biracial community cohort of 732 young women - 50% African-American and 50% Caucasian - specifically investigating incidence, remission, and progression of, as well as factors associated with commo...
The Role of Suggestions in Hypnosis for Chronic Pain: A Review of the Literature [0.03%]
催眠中建议在慢性疼痛治疗中的作用：文献综述
Tiara Dillworth,Mark P Jensen
Tiara Dillworth
Several controlled trials have demonstrated that hypnosis is an efficacious treatment for chronic pain. However, less attention has been given to the specific procedures and suggestions used in hypnotic treatments in research. The goal of t...
Contribution of Primary Afferent Input to Trigeminal Astroglial Hyperactivity, Cytokine Induction and NMDA Receptor Phosphorylation [0.03%]
初级传入对三叉神经胶质高活性、细胞因子诱导和NMDA受体磷酸化的作用贡献
H Wang,W Guo,K Yang et al.
H Wang et al.
We tested the hypothesis that primary afferent inputs play a role in astroglial hyperactivity after tissue injury. We first injected complete Freund's adjuvant (CFA, 0.05 ml, 1:1 oil/saline) into the masseter muscle, which upregulated glial...
Focal Inflammation Causes Carbenoxolone-Sensitive Tactile Hypersensitivity in Mice [0.03%]
焦灶性炎症引起小鼠的卡巴氧敏感性触诱发敏反应
Regina Hanstein,Julie B Zhao,Rajshekhar Basak et al.
Regina Hanstein et al.
A focal and transitory inflammation induced by injection of complete Freund's adjuvant (CFA) in the submandibular skin of mice elicits pain behavior that persists for several weeks after the initial inflammation has resolved. Chronic pain, ...