Clinical trials of the past decade in the management of chronic kidney disease [0.03%]
近十年慢性肾脏病管理的临床试验
Keng-Thye Woo,Kok-Seng Wong,Choong-Meng Chan
Keng-Thye Woo
The three main causes of Chronic Kidney Diseases [CKD] are diabetes mellitus, chronic glomerulonephritis and hypertension. CKD is an increasing burden in the community as more patients fall prey to kidney failure. Both dialysis and renal tr...
Is there a benefit from the concomitant use of immunosupression with anti-TNF in Crohn's disease; heads or tails? [0.03%]
抗TNF治疗克罗恩病时联合使用免疫抑制剂是否有益？正方还是反方？
Peter Laszlo Lakatos
Peter Laszlo Lakatos
Over the last some years the increasing knowledge on the pathogenesis of Crohn's disease led to the development of a number of biological agents targeting specific molecules involved in gut inflammation, first of all TNF-alpha and its recep...
Accelerated hypofractionated radiotherapy schedules in breast cancer: a review of the current literature [0.03%]
乳腺癌超分割放射治疗方案的现状及文献回顾
Maria Aggeliki Kalogeridi,Nikolaos Kelekis,John Kouvaris et al.
Maria Aggeliki Kalogeridi et al.
Lumpectomy followed by breast irradiation is an alternative to mastectomy for patients with early-stage breast cancer. The purpose of radiation treatment following lumpectomy is to minimize the risk of recurrent cancer in the treated breast...
Percutaneous radiofrequency ablation for unresectable colorectal liver metastases: time for shadows to disperse [0.03%]
不可手术的结直肠癌肝转移患者经皮射频消融治疗：拨云见日之时？
Loukia S Poulou,Panayiotis D Ziakas,Vassilia Xila et al.
Loukia S Poulou et al.
Background: Despite the advent of combination chemotherapy regimens achieved within the last decade, long term survival of patients with unresectable metastatic disease from colorectal cancer remains poor. Thermal ablatio...
Agustin Avilés
Agustin Avilés
Management of hematological malignancies (HM) during pregnancy remains unsolved. Presence of adverse events in mother and child: spontaneous abortion, stillborn, premature, low-weight and congenital abnormalities have been attributed to the...
Michael Pazianas,Solomon Epstein,Mone Zaidi
Michael Pazianas
Oral bisphosphonate dosing schedules have evolved from the original daily regimens to weekly (alendronate and risedronate) and monthly (risedronate and ibandronate) regimens. Intravenous (i.v.) bisphosphonates are administered less frequent...
Chemoradiotherapy in locally advanced, unresectable non-small cell lung cancer [0.03%]
局部晚期不可切除的非小细胞肺癌的化学放射治疗
Lauren R Mitchell,Jeffrey M Albert,Bo Lu
Lauren R Mitchell
Chemoradiation is the major treatment option in unresectable, locally advanced non-small cell lung cancer. Many clinical trials have evaluated the efficacy of different combinations of chemotherapy and radiotherapy in this heterogeneous pat...
Bisphosphonate osteonecrosis (BON): unanswered questions and research possibilities [0.03%]
关于双膦酸盐性骨坏死(BON)：未回答的问题和研究的可能性
Cesar A Migliorati,Mark M Schubert,Douglas E Peterson
Cesar A Migliorati
Bisphosphonate osteonecrosis (BON) is a relatively recent adverse drug event that affects the oral cavity almost exclusively. It has been reported in individuals with metastatic breast, prostate, and lung cancer as well as in multiple myelo...
Long-term bronchodilator inhaled therapy in COPD: the role of tiotropium bromidum [0.03%]
慢性阻塞性肺疾病长期吸入性支气管扩张疗法中的噻托溴铵的作用
Sabina A Antoniu
Sabina A Antoniu
Chronic obstructive pulmonary disease (COPD) is an inflammatory disease of the lungs in which airways inflammation related mainly to smoking causes progressive airflow obstruction and chronic respiratory symptoms such as dyspnea or cough. C...
Vance W Berger,Sunny Y Alperson
Vance W Berger
Flawed evaluation of clinical trial quality allows flawed trials to thrive (get funded, obtain IRB approval, get published, serve as the basis of regulatory approval, and set policy). A reasonable evaluation of clinical trial quality must r...