Piera Capranzano,Davide Capodanno,Corrado Tamburino
Piera Capranzano
Although standard anticoagulation, including heparins and vitamin K antagonists (VKA), is clinically beneficial, several unmet needs remain due to several pharmacokinetic and pharmacodymamic limitations. Selective anticoagulant agents have ...
A critical reappraisal of off-label indications for topical photodynamic therapy with aminolevulinic acid and methylaminolevulinate [0.03%]
ALA和MAL外用光动力治疗的适应证再评价
Piergiacomo Calzavara-Pinton,Mariachiara Arisi,Elena Sereni et al.
Piergiacomo Calzavara-Pinton et al.
Photodynamic therapy (PDT) with methylaminolevulinate (MAL) has demonstrated high efficacy, minimal side effects, and improved cosmetic outcome in the treatment of its EU-approved clinical indications, i.e. actinic keratoses (AKs), basal ce...
Marco Berlucchi,Michele Sessa
Marco Berlucchi
Adenoidal hypertrophy is probably the most frequent pathology in the pediatric population. This disorder manifests with several symptoms such as bilateral nasal obstruction, rhinorrhea, cough, snoring, hyponasal speech, hypopnea, and sleep ...
Treatment of bone metastases in lung cancer: the actual role of zoledronic acid [0.03%]
肺癌骨转移的治疗：唑来磷酸的实际作用
Serena Ricciardi,Filippo de Marinis
Serena Ricciardi
Approximately 30-40% of NSCLC patients develop bone metastases. Bone metastases are associated with a significant increase in skeletal-related events (SREs), including severe bone pain, hypercalcemia, pathological fractures, spinal cord com...
Parallel conduction of the phase I preventive and therapeutic trials based on the Tat vaccine candidate [0.03%]
基于Tat疫苗候选物的I期预防和治疗临床试验平行方案
S Bellino,V Francavilla,O Longo et al.
S Bellino et al.
The native HIV-1 Tat protein was chosen as vaccine candidate for phase I clinical trials in both uninfected (ClinicalTrials.gov identifier: NCT00529698) and infected volunteers (ClinicalTrials.gov identifier: NCT00505401). The rationale was...
Spectrum of benign lesions mimicking a malignant stricture at the liver hilum [0.03%]
肝门部恶性狭窄的良性病变的内镜特征分析
Woubet Tefera Kassahun,Sven Jonas
Woubet Tefera Kassahun
There is a broad spectrum of benign disorders of the biliary system that resemble hilar cholangiocarcinoma (HCCA) in terms of clinical, pathologic, and imaging findings. No unifying features were found to characterize patients with benign h...
Masaru Enomoto,Akihiro Tamori,Norifumi Kawada
Masaru Enomoto
Infection with hepatitis C virus (HCV) is a global health problem that affects approximately 170 million people worldwide. The current standard therapy with peginterferon alpha plus ribavirin for 48 weeks results in a sustained virologic re...
Alessandro Di Filippo,Chiara Gonnelli
Alessandro Di Filippo
Rapid sequence intubation is an essential bullet in the maintenance of patency of the airway during intubation in emergency. It is a valid method in all those situations where you can not determine whether the patient is fasting or not. But...
Chia (Salvia hispanica): a systematic review by the natural standard research collaboration [0.03%]
奇异藜（Salvia hispanica）：自然标准研究协作组织的系统评价报告
Catherine Ulbricht,Wendy Chao,Katie Nummy et al.
Catherine Ulbricht et al.
Objective: To evaluate the scientific evidence on chia (Salvia hispanica) including history, folkloric precedent, expert opinion, pharmacology, dosing, interactions, adverse effects, and toxicology. This review serves as ...
The use of bevacizumab and trastuzumab beyond tumor progression: a new avenue in cancer treatment? [0.03%]
贝伐单抗和曲妥珠单抗超越肿瘤进展使用：癌症治疗的新途径？
F Meriggi,C Abeni,B Di Biasi et al.
F Meriggi et al.
The use of the Monoclonal Antibodies (MoAbs) Bevacizumab (B) and Trastuzumab (T) beyond clinical progression in colorectal and breast cancer treatment is among the hottest topics in today's clinical oncology. Both observational and prospect...