Antidepressant use in children and adolescents diagnosed with major depressive disorder: what can we learn from published data? [0.03%]
抗抑郁药在儿童及青少年抑郁症患者中的使用：已发表数据能告诉我们什么？
Salvatore Gentile
Salvatore Gentile
Objective: The consequences of major depression disorder (MDD) in youths are likely to be devastating for both the patient and his/her family. Thus, this review analyzes systematically the effectiveness of antidepressant ...
Michael S Rafii
Michael S Rafii
Therapies that are believed to target the underlying mechanisms of Alzheimer's disease have now reached human clinical trials, with the number of agents in late stage development having increased dramatically in recent years. Primary target...
What else in gemcitabine-pretreated advanced pancreatic cancer? An update of second line therapies [0.03%]
吉西他滨预处理的晚期胰腺癌二线疗法进展更新
Fausto Petrelli,Karen Borgonovo,Mara Ghilardi et al.
Fausto Petrelli et al.
Advanced pancreatic cancer is usually treated with first-line gemcitabine (GEM) (alone or in combination). More recently, GEM has become an established part of an adjuvant therapy based on two recently-reported randomized trials. There rema...
The role of continuous positive airway pressure in the treatment of hypertension in patients with obstructive sleep apnea-hypoapnea syndrome: a review of randomized trials [0.03%]
持续正压通气在阻塞型睡眠呼吸暂停低通气综合征患者降压治疗中作用的系统评价与 meta 分析
Mohan Rao,Geet Rajda,Sarada Uppuluri et al.
Mohan Rao et al.
Obstructive sleep apnea-hypoapnea syndrome (OSA) is a disorder that results in repetitive occlusion of the airway and hypoxemia during sleep. Epidemiologic studies have associated this disorder with increased cardiovascular morbidity and mo...
Diptesh Gupta,Kunal Chaudhary,Ravi Nistala
Diptesh Gupta
Renal artery stenosis is the most common cause of secondary hypertension after exclusion of renal parenchymal disease and/or hypertensive nephrosclerosis. Atherosclerotic processes comprise the major contributors to this condition and accou...
Allison Quick,Disha Patel,Mersiha Hadziahmetovic et al.
Allison Quick et al.
Glioblastoma (GBM), a WHO grade IV malignant glioma, is the most common and lethal adult primary brain tumor. Median survival rates range from 12-15 months. The current standard of care for GBM has evolved from resection followed by adjuvan...
The potential of lifestyle changes for improving the clinical outcome of patients with coronary heart disease: mechanisms of benefit and clinical results [0.03%]
冠心病患者改善临床预后的潜在生活方式改变：获益机制和临床结果
Domenico Scrutinio
Domenico Scrutinio
There is overwhelming evidence that smoking cessation, regular physical activity, and combined dietary changes are beneficial in patients with coronary heart disease. Effect size estimates for these lifestyle goals vary between 20% and 35% ...
Gian Galeazzo Riario-Sforza,Mona-Rita Yacoub,Cristoforo Incorvaia
Gian Galeazzo Riario-Sforza
During the 80' and the 90's, the role of pulmonary rehabilitation (PR) was still not clearly demonstrated. The following development of PR was mainly due to the increasing number of clinical studies providing proofs of its effectiveness, an...
Jesus Peteiro,Alberto Bouzas-Mosquera
Jesus Peteiro
Stress echocardiography is a useful tool for the clinical decision making process, given its accuracy and demonstrated prognostic value. Among available stress echocardiography techniques, exercise is safer and more physiologic, therefore m...
Stable disease in renal cell carcinoma after using signal transduction inhibitors [0.03%]
靶向药物治疗后的肾细胞癌患者病情稳定期的临床分析
Saby George,Shetal N Shah,Ronald M Bukowski
Saby George
Malignant solid tumors have been traditionally treated utilizing cytotoxic chemotherapies, which work against rapidly multiplying tumors. The current response evaluation in solid tumor is based on the Response Evaluation Criteria in Solid T...