Development of inhibitors of the IGF-IR/PI3K/Akt/mTOR pathway [0.03%]
IGF-IR/PI3K/Akt/mTOR信号传导途径抑制剂的研发进展
Mary L Hixon,Luisa Paccagnella,Robert Millham et al.
Mary L Hixon et al.
Progress has been made towards the development of agents targeting tyrosine kinase receptors and other molecules involved in signalling pathways important for cell proliferation, motility, and apoptosis. Inhibitor molecules designed to be h...
James J Marriott,Paul W O&#x;Connor
James J Marriott
Disease modifying therapy (DMT) first became available for relapsing-remitting multiple sclerosis (RRMS) fifteen years ago with the development of the moderately effective injectable agents interferon (IFN)-beta and glatiramer acetate (GA)....
Evaluation of self monitoring of blood glucose in non-insulin-treated diabetic patients by randomized controlled trials: little bang for the buck [0.03%]
非胰岛素治疗的糖尿病患者自我监测血糖评价：随机对照试验结果并不令人满意
Mayer B Davidson
Mayer B Davidson
Although self monitoring of blood glucose is accepted to be effective in lowering Hb A1c levels in insulin-treated diabetic patients, any benefit in non-insulin-treated patients remains controversial. Observational studies cannot answer thi...
Mirena intra-uterine system: does it improve long term symptoms in women with chronic pelvic pain and/or endometriosis after laparoscopy? A multicentre randomized controlled trial [0.03%]
有关慢性盆腔痛和/或子宫内膜异位症的妇女宫腔内置入Mirena系统改善腹腔镜术后长期症状的有效性的多中心随机对照试验
Dalya Alhamdan,Tommaso Bignardi,George Hardas et al.
Dalya Alhamdan et al.
Background: Chronic pelvic pain (CPP) is a complex clinical scenario, which affects 15% of women. The published literature lacks a consistent definition of CPP. However according to Vercillini et al., CPP is defined by th...
Randomized Controlled Trial
Reviews on recent clinical trials. 2010 Sep;5(3):143-6. DOI:10.2174/157488710792007301 2010
The pathogenesis, complications and therapeutic strategy for hepatitis C virus-associated insulin resistance in the era of anti-viral treatment [0.03%]
抗病毒治疗时代丙型肝炎病毒感染相关胰岛素抵抗的发生机制、并发症及治疗策略
Takumi Kawaguchi,Eitaro Taniguchi,Minoru Itou et al.
Takumi Kawaguchi et al.
Recent experimental and clinical studies have shown that chronic hepatitis C virus (HCV) infection causes insulin resistance. Since insulin resistance decreases response to antiviral treatments, promotes inflammatory and fibrogenic reaction...
Recent advances in hepatitis C virus treatment: review of HCV protease inhibitor clinical trials [0.03%]
近年丙型肝炎治疗的进展：HCV蛋白酶抑制剂临床试验综述
Aarthi Chary,Mark Holodniy
Aarthi Chary
Hepatitis C virus (HCV) infection affects millions of people world-wide, and chronic infection can result in end-stage liver disease and hepatocellular carcinoma. Conventional therapy to date has involved combination antiviral therapy inclu...
Voichita Bar Ad
Voichita Bar Ad
Objectives: Gabapentin was initially developed as an antiepileptic drug but was later discovered to be an effective treatment of neuropathic pain. Gabapentin has been successfully used for the treatment of multiple neurop...
Aortic arch calcification and mortality in chronic hemodialysis patients [0.03%]
慢性血液透析患者主动脉弓钙化与死亡率的关系
Kosaku Nitta,Tetsuya Ogawa
Kosaku Nitta
Vascular calcification is associated with poor prognosis in hemodialysis (HD) patients. It can be assessed with computed tomography (CT) but simple in-office techniques may provide a useful information. We compared the results obtained with...
Hypofractionated radiotherapy in non small cell lung cancer: a review of the current literature [0.03%]
非小细胞肺癌超分割放射治疗文献回顾
I Beli,G Koukourakis,K Platoni et al.
I Beli et al.
Hypofractionated irradiation has an established role in the palliative treatment of patients with advanced medically inoperable non - small cell lung cancer (NSCLC ) and poor performance status. Also hypofractionated radiotherapy merits car...
Manual thrombectomy during primary coronary intervention in acute myocardial infarction: a brief review [0.03%]
急性心肌梗死冠脉介入治疗中的手动血栓抽吸：综述型论文
Andrea Rognoni,Luigi Corrado,Sergio Maccio et al.
Andrea Rognoni et al.
The no - reflow phenomenon occurs in one third of the patients treated with primary percutanous intervention for acute ST segment elevation myocardial infarction. In addition of the effect of prolonged ischaemia, also reperfusion injury con...