Prevention and treatment of diabetic retinopathy: evidence from large, randomized trials. The emerging role of fenofibrate [0.03%]
糖尿病视网膜病变的预防和治疗：来源于大规模随机试验的证据。非诺贝特的作用不容忽视
Rafael Simó,Cristina Hernández
Rafael Simó
Diabetic retinopathy (DR) remains a leading cause of preventable vision loss, despite advances in diabetes care. The burden of DR is likely to increase as the evolving pandemic of type 2 diabetes progresses. Tight control of blood glucose l...
Sugammadex, a promising reversal drug. A review of clinical trials [0.03%]
有关 Sugammadex 的临床试验回顾（一种新型解药）
Ira Makri,Artemisia Papadima,Aimilia Lafioniati et al.
Ira Makri et al.
According to published data, sugammadex, rapidly reverses (2-5 min) shallow and profound NM block induced by rocuronium and vecuronium, without being connected with serious adverse events. It is accepted that in order to reverse shallow blo...
A critical systematic review of recent clinical trials comparing open retropubic, laparoscopic and robot-assisted laparoscopic radical prostatectomy [0.03%]
近期开放性经腹膜外、腹腔镜及机器人辅助腹腔镜前列腺癌根治术临床试验的系统评价与Meta分析
R Heer,I Raymond,M J Jackson et al.
R Heer et al.
The surgical treatment of prostate cancer has evolved rapidly, driven by technological advances that have made minimally-invasive prostatectomy feasible. The contemporary surgical approaches are laparoscopic radical prostatectomy (LRP) and ...
Georgios Aperis,Polichronis Alivanis
Georgios Aperis
The last twenty years, the incidence of invasive fungal infections (IFI) has risen dramatically due to the prolongation of survival of patients with multiple risk factors for fungal infections. Amphotericin B was for more than 40 years the ...
Clinical trials using vasodilators in pulmonary arterial hypertension: where do we go from here? [0.03%]
肺动脉高压使用血管扩张剂临床试验的现状及展望
Alejandro Macchia,Javier Mariani,Pablo Dino Comignani et al.
Alejandro Macchia et al.
Background: The impact of treatment with vasodilators on the survival of patients with pulmonary arterial hypertension (PAH) remains uncertain. Despite several clinical trials have been carried out in the last 15 years, t...
Nosocomial MRSA pneumonia: data from recent clinical trials [0.03%]
医院获得性耐甲氧西林金黄色葡萄球菌肺炎的临床试验数据recent Clinical trial
M Karvouniaris,D Makris,D Karabekos et al.
M Karvouniaris et al.
MRSA infections, especially pneumonia have been associated with considerable morbidity and mortality and the management of MRSA infections is considered as an issue of high priority for scientific societies. Many studies which have been pub...
Targeted-therapy and imaging response: a new paradigm for clinical evaluation? [0.03%]
靶向治疗和影像学反应：临床评价的新范式？
Amalia Milano,Francesco Perri,Andrea Ciarmiello et al.
Amalia Milano et al.
Clinical management of patients with malignant tumors has dramatically changed over the last years with the introduction of novel therapeutics, such as receptor-targeted therapies, downstream effectors and antiangiogenic compounds. This has...
Clinical trials in relapsing-remitting multiple sclerosis /a new proposal for dealing with basic problems and restrictions [0.03%]
复发缓解性多发性硬化症临床试验的新建议以解决基础问题和限制
Mieczyslaw Wender,Grazyna Michalowska-Wender
Mieczyslaw Wender
The natural course of multiple sclerosis is characterized by a high variability of pattern, relapse rate and different progression indices. They also present a dramatic impact on the interpretation of treatment trials. Reports, based on unc...
Phillip Dinh,Jin Sun,Steve Bai et al.
Phillip Dinh et al.
The objective of this study was to examine the drug-induced sex differences in corrected QT (QTc) interval by re-analyzing the data collected in thorough QT studies submitted to the US Food and Drug Administration (FDA). We examined 64 stud...
Recent advances of kinesin motor inhibitors and their clinical progress [0.03%]
肌球蛋白抑制剂研究的最新进展及其临床应用展望
Antiopi Voultsiadou,Vasiliki Sarli
Antiopi Voultsiadou
Antimitotic chemotherapy remains the most effective approach to treat a variety of human neoplasms. Since the discovery of tubulin-targeting agents, vinca alkaloids and the taxanes including paclitaxel and docetaxel are used clinically to t...