Selumetinib in advanced non small cell lung cancer (NSCLC) harbouring KRAS mutation: endless clinical challenge to KRAS-mutant NSCLC [0.03%]
塞利帕替尼治疗携带KRAS突变的晚期非小细胞肺癌(NSCLC):针对KRAS突变型NSCLC的临床挑战
Maione Paolo,Sgambato Assunta,Rossi Antonio et al.
Maione Paolo et al.
During the past few years, oncologists have witnessed the reclassification of non small cell lung cancer (NSCLC) as not one disease, but several molecularly defined subsets of disease with relevant therapeutic implications in the field of m...
Somatic treatments excluding psychopharmacology in obsessive- compulsive disorder: a review [0.03%]
除外精神药理学的OCD躯体治疗：一篇综述
Murad Atmaca
Murad Atmaca
Somatic treatments other than psychotropic drugs are increasingly used in the patients with obsessive compulsive disorder (OCD), however there has been little systematic review of them. Therefore, the present review deals with a variety of ...
Murad Atmaca
Murad Atmaca
In the present article, structural, neurochemical and functional neuroimaging investigations performed on patients with social anxiety disorder were reviewed. A PubMed search was performed to identify all structural and functional neuroimag...
Chemotherapeutic options for colorectal cancer patients with cardiovascular diseases [0.03%]
心血管病患者的结直肠癌化疗选择
Brunella Di Biasi,Tiziana Prochilo,Tony Sabatini et al.
Brunella Di Biasi et al.
The high incidence of cardiovascular disease and colorectal cancer in the world's population means that these two conditions may coexist in the same patient. In addition fluoropyrimidines, backbone for the treatment of colorectal cancer in ...
Emerging evidence that radial is safer than femoral percutaneous coronary intervention in subjects with ST segment elevation myocardial infarction [0.03%]
经皮冠状动脉介入治疗中新的证据表明对于ST段抬高性心肌梗死患者，桡动脉途径比股动脉途径更安全
Giancarla Scalone,Francesco Burzotta,Cristina Aurigemma et al.
Giancarla Scalone et al.
Bleeding complications in patients with acute coronary syndromes are a significant predictor of mortality. Trans-radial approach (TRA) is a promising strategy to reduce bleedings in patients undergoing invasive coronary procedures. Recently...
Murad Atmaca,Faruk Kilic,Abdulgani Temizkan et al.
Murad Atmaca et al.
Objective: In this retrospective study, we aimed to evaluate platelet changes in patients taking clozapine for a variety of psychiatric disorders and hypothesized that there would be any changes in the course of the treat...
Efficacy and Safety of Sofosbuvir in the Treatment of Chronic Hepatitis C: The Dawn of a New Era [0.03%]
索磷布韦治疗慢性丙型肝炎的疗效和安全性：新纪元的到来
Ivan Gentile,Federico Borgia,Emanuela Zappulo et al.
Ivan Gentile et al.
Hepatitis C virus (HCV) infection affects about 160 million people worldwide. Currently, it is treated with pegylated interferon (PEG-IFN) plus ribavirin, associated with a protease inhibitor in case of genotype 1 infection. However, this c...
New alternative anticoagulants in atrial fibrillation: the move beyond warfarin [0.03%]
房颤的新替代抗凝药物：华法林以外的选项
Ashish A Bhimani,Mauricio Hong
Ashish A Bhimani
Given the increasing prevalence of atrial fibrillation, the need for safe and effective stroke prophylaxis will continue to rise. Warfarin has been around for many years and has proven efficacy in preventing stroke, but it has major limitat...
Cetuximab/irinotecan-chemotherapy in KRAS wild-type pretreated metastatic colorectal cancer: a pooled analysis and review of literature [0.03%]
一项关于西妥昔单抗/伊立替康化疗在经治野生型KRAS基因转移性结直肠癌中的疗效的文献综合分析及回顾
Sandro Barni,Mara Ghilardi,Karen Borgonovo et al.
Sandro Barni et al.
Introduction: Cetuximab and irinotecan are effective agents in advanced colorectal cancer (CRC) after either irinotecanor oxaliplatin-based first-line chemotherapy. Here, the efficacy of this combination in patients with ...
Michael S Rafii
Michael S Rafii
Alzheimer's disease (AD) is the leading cause of dementia worldwide. Clinically, it is characterized by progressive cognitive impairment and the emergence of neuropsychiatric disturbances. In recent years, many drug candidates aimed at dise...