Exploring Challenges and Opportunities for Improving Phase 2 and Phase 3 Clinical Trials: A Review [0.03%]
改善二期和三期临床试验的挑战与机遇：综述式研究论文
Bureddi Anudeep Venkata Sai,Sangita Mishra,M P Venkatesh
Bureddi Anudeep Venkata Sai
Introduction: Clinical trials are indispensable for advancing drug discovery, yet Phase 2 and Phase 3 studies are frequently hampered by escalating costs, high attrition rates, and complex operational hurdles. This review...
Ethical Preparedness of Developing Nations in the Age of Decentralized Clinical Trials: Comparative Overview of South Asian Regulation [0.03%]
发展中国家在去中心化临床试验时代的伦理准备情况：南亚监管的比较概述
Yashika,Amandeep Singh
Yashika
The advent of decentralized clinical trials (DCTs) has altered the usual trends in clinical trials, and this presents an ethical, regulatory, and operational dilemma, particularly to the low-and middle-income countries (LMICs). This review ...
Secondary Thyroid Cancer Risks from External Beam Radiation Exposure Modulated by Dose, Field, Sex, Age, and Latency Period [0.03%]
二次电离辐射诱发甲状腺癌风险的剂量-效应关系及其它影响因素
Georgia Koutsouki,Ilias Katsadouros,Evanthia Giannoula et al.
Georgia Koutsouki et al.
Introduction: Exposure to ionizing radiation is a well-established risk factor for the development of thyroid malignancies. Given the fact that the thyroid gland is a particularly radiosensitive organ and consequently vul...
A Systematic Review of Different Analytical Methods for the Quantification of Natural Bioactives [0.03%]
天然活性物质定量的不同分析方法的系统评价
Shashank Rai,Snigdha Bhardwaj,Kandasamy Nagarajan et al.
Shashank Rai et al.
Introduction: Natural bioactive compounds have significant potential for the development of therapeutic interventions, but the success of their discovery and use is greatly influenced by the development of efficient metho...
Leqembi (Lecanemab) in Early Alzheimer's Disease: A Review of Clinical Trial Evidence and Therapeutic Implications [0.03%]
仑卡奈单抗在早老性痴呆中的临床试验证据及治疗意义评述
Andrew Ashchi,Andrea Ashchi Lachapelle,Selim Nassirou et al.
Andrew Ashchi et al.
Lecanemab is an IgG1 monoclonal antibody that has emerged as the first FDAapproved drug to slow the progression of Alzheimer's disease by targeting amyloid plaques, with the potential to serve as a disease-modifying therapy. Ongoing clinica...
Restricted and Repetitive Behaviors in Intellectual Disabilities: A Scoping Review with a Systematic Search of the Literature [0.03%]
有限和重复行为在智力障碍中的作用：文献系统检索的范畴性综述
Emily Payne,Sara Sarasua,Curtis Rogers et al.
Emily Payne et al.
Background: Restricted and Repetitive Behaviors (RRBs) are a core feature of autism and are present in numerous neurodevelopmental disorders and Intellectual Disabilities (ID). These behaviors include repetitive movements...
Artificial Intelligence in Phenylketonuria: Bridging Conventional Gaps in Diagnosis and Treatment- A Systematic Review [0.03%]
苯酮尿症中的人工智能：诊断与治疗常规缺口的桥梁——系统性综述
Zulfa Nooreen,Ankita Wal,Himangi Vig et al.
Zulfa Nooreen et al.
Introduction: Phenylketonuria (PKU) is an autosomal recessive condition of phenylalanine metabolism, characterized by abnormally high phenylalanine concentrations that lead to brain damage. These illnesses are caused by m...
Virtual Clinical Trials in Clinical Medicine: Economic, Ethical, and Practical Considerations [0.03%]
虚拟临床试验在临床医学中的经济、伦理和实践考量
Francisco Epelde,Dolores Rexachs,Alvaro Wong et al.
Francisco Epelde et al.
Virtual clinical trials (VCTs) represent an innovative approach to clinical research, using computer simulations and digital modeling rather than traditional human participants. These trials harness computational power and artificial intell...
Immunological and Hematological Characterisation of Mycobacterium Tuberculosis (M. Tb) Infected Patients [0.03%]
结核分枝杆菌感染患者的免疫及血液学特征分析
Mariam Ahmed Mujtaba,Hira Shahzad,Muhammad Ishaq Javed et al.
Mariam Ahmed Mujtaba et al.
Introduction: Differentiating TB phenotypes remains a diagnostic challenge due to the absence of a universally accepted standard test. Although the interferon gamma release assay (IGRA) is recommended for Latent TB Infect...
Nutritional Implications of Methotrexate in Osteoarthritis: A Systematic Review and Meta-Analysis [0.03%]
甲氨蝶呤在骨关节炎中的营养影响：系统评价和.meta.-分析
Saud Nayef Salem Aldanyowi,Abdulsalam Mohammed Aleid,Yousef Khalaf A Alghamdi et al.
Saud Nayef Salem Aldanyowi et al.
Introduction: Osteoarthritis (OA) is a prevalent degenerative joint condition with limited treatment options targeting disease modification. Methotrexate (MTX), widely used in rheumatoid arthritis for its anti-inflammator...