Production of anti-CD14 monoclonal antibody using synthetic peptide of human CD14 as immunizing antigen [0.03%]
以人CD14合成肽为免疫原制备抗CD14单克隆抗体
Leili Aghebati Maleki,Dariush Shanehbandi,Jafar Majidi et al.
Leili Aghebati Maleki et al.
Background: CD14 is a myeloid differentiation antigen expressed primarily on peripheral blood monocytes, dendritic cells and macrophages. It is a key regulator of inflammatory responses to gram-negative bacteria, oxidativ...
Establishment of human clones producing neutralizing human monoclonal antibodies to the envelope E1/E2 protein of hepatitis C virus by EBV immortalization of immune CD22⁺ B cells [0.03%]
EB病毒免疫CD22⁺B细胞永生化建立人源抗HCV包膜E1/E2蛋白中和单克隆抗体的人源细胞系
Ashraf Tabll,Yasmine El Abd,Noha G Bader El Din et al.
Ashraf Tabll et al.
We aimed to establish Human cell lines producing human monoclonal antibodies to the envelope E1/E2 protein of hepatitis C virus (HCV). Two protocols for EBV immortalization of CD22⁺ cells separated from HCV positive patients were used; 1) ...
Fatemeh Zare Shahneh
Fatemeh Zare Shahneh
The detection of Circulating Tumor Cells (CTC) is a purpose in numerous oncology research fields. CTCs are disseminated from the original site from metastatic and primary tumors in the peripheral blood of breast, prostate, lung and colorect...
Presence of aberrant VH6 domains in anti-interferon-γ autoantibodies in multiple sclerosis [0.03%]
多重硬化症中干扰素-γ自身抗体的VH6突变型抗原受体片段多样性
Marina A Tyumentseva,Vera V Morozova,Leonid R Lebedev et al.
Marina A Tyumentseva et al.
Background: Anti-cytokine autoantibodies (auto-Abs) are ubiquitous both in patients suffering from infectious, inflammatory and autoimmune diseases and in healthy individuals. Particularly anti-IFN-γ auto-Abs are shown t...
Developing and mature human granulocytes express ELP 6 in the cytoplasm [0.03%]
人粒细胞的ELP 6胞浆表达及其转录调控分析
Lori A Wagner,Shuping Wang,Elizabeth A Wayner et al.
Lori A Wagner et al.
Background: c3orf75 is a conserved open reading frame within the human genome and has recently been identified as the Elongator subunit, ELP6 [1]. The Elongator enzyme complex has diverse roles, including translational co...
Fatemeh Zare Shahneh,Behzad Baradaran,Fatemeh Zamani et al.
Fatemeh Zare Shahneh et al.
Angiogenesis, the development and growth of blood vessels, is a major topic of research which began in 1971 with Folkman's original hypothesis. Different mechanisms of blood vessel growth are sprouting and intussusceptive angiogenesis, vasc...
Future prospects of monoclonal antibodies as magic bullets in immunotherapy [0.03%]
单克隆抗体在免疫治疗中作为魔法子弹的前景展望
Leili Aghebati Maleki,Behzad Baradaran,Jafar Majidi et al.
Leili Aghebati Maleki et al.
Monoclonal antibody therapy has become a critical component of clinical treatment procedure for a variety of indications. Therapeutic antibodies have made the transition from conception to clinical reality over the past two decades. Now, ma...
Production and characterization of murine monoclonal antibody against synthetic peptide of CD34 [0.03%]
抗CD34合成肽单克隆抗体的制备及鉴定
Leili Aghebati Maleki,Jafar Majidi,Behzad Baradaran et al.
Leili Aghebati Maleki et al.
Background: The treatment of hematologic malignancies and immunodeficiency diseases are offered by hematopoietic stem cells (HSCs) as a unique self-renewal and differentiation source which most commonly is selected by CD3...
Clonal analysis of human anti-V3 monoclonal antibodies selected by a V3 tetramer [0.03%]
人抗V3单克隆抗体的克隆分析（采用V3四聚体筛选）
Liuzhe Li,Xiao-Hong Wang,Sagarika Banerjee et al.
Liuzhe Li et al.
The production of human monoclonal antibodies (mAbs) has been improved recently using the single B cell and PCR technology. A number of new anti-HIV-1 mAbs directed to various epitopes were produced by selecting single B cells from HIV posi...
Development and characterization of monoclonal antibodies against human CD20 in Balb/c mice [0.03%]
BALB/C小鼠抗人CD20单克隆抗体的研制及鉴定
Koushan Sineh Sepehr,Behzad Baradaran,Jafar Majidi et al.
Koushan Sineh Sepehr et al.
Background: Targeting CD20 antigen on B-lymphocytes provides good opportunity for management of the target cells in patients with B-cell malignancies. By the advent of hybridoma technology, monoclonal antibodies applicati...