Alberto L Horenstein,Antonella Chillemi,Valeria Quarona et al.
Alberto L Horenstein et al.
This review focuses on the concept of antibodies acting as receptor agonists and antagonists, and on the potential relevance of this notion in applied medicine. Antibodies are composed of three functional units: two antigen-binding fragment...
Seroprevalence and diagnosis of HIV, HBV, HCV and syphilis infections among blood donors [0.03%]
献血者中HIV、HBV、HCV和梅毒感染的血清流行率及诊断
Tadesse Bekele Tafesse,Addis Adera Gebru,Semgne Gobalee et al.
Tadesse Bekele Tafesse et al.
Background: Blood transfusion is one of the most important therapeutic options of life-saving intervention for recipients who are in diseased or non-diseased conditions with severe blood loss. However, it is associated wi...
The effect of Base Transceiver Station waves on some immunological and hematological factors in exposed persons [0.03%]
移动基站电磁波对接触人群免疫及血液学指标的影响研究
Mohammad Taheri,Ghodratollah Roshanaei,Jamileh Ghaffari et al.
Mohammad Taheri et al.
Background: Since the number of mobile subscribers has significantly increased in recent years, the installation and deployment of Base Transceiver Station (BTS) antennas sending and receiving signals has become common an...
Adjuvants for Clostridium tetani and Clostridium diphtheriae vaccines updating [0.03%]
破伤风及白喉杆菌疫苗佐剂新论
Fatimah M Alshanqiti,Saad B Al-Masaudi,Ahmed M Al-Hejin et al.
Fatimah M Alshanqiti et al.
It's known that diphtheria and tetanus are a contagious lethal diseases over the years, they caused by pathogenic microbes corynebacterium diphtheria and Clostridium tetani, respectively. The diseases result from the production of bacterial...
Epitope analysis of Japanese cedar pollen allergen Cry j2 with a human IgM class monoclonal antibody 404-117 [0.03%]
人单克隆抗体404-117对日本扁柏花粉过敏原Cry j2的表位分析
Seiya Chiba,Haruka Yokoyama,Ayane Kumazawa et al.
Seiya Chiba et al.
Japanese cedar pollen allergen Cry j2 is a causal allergen of seasonal pollinosis in Japan. To analyze B cell epitopes of Cry j2, we established two human-mouse hybridomas secreting IgM class human monoclonal antibodies to Cry j2. A pin-pep...
Of patents and patent disputes: The TNFα patent files. Part 1: Humira [0.03%]
专利的故事：TNFα专利纠纷系列（一）Humira的故事
Ulrich Storz
Ulrich Storz
This article discusses the patent strategy underlying the world's best selling drug, AbbVie's Humira®. Despite a non-optimal starting position, AbbVie has established an extensive portfolio to fend off biosimilar competition. This article ...
Single nucleotide polymorphisms in the FOXP3 gene are associated with increased risk of relapsing-remitting multiple sclerosis [0.03%]
FOXP3基因单核苷酸多态性与复发缓解型多发性硬化的发病风险增加有关
Mohammad Mahdi Eftekharian,Arezou Sayad,Mir Davood Omrani et al.
Mohammad Mahdi Eftekharian et al.
Background: Although Multiple Sclerosis (MS) is an autoimmune multifactorial disease with unknown etiology, various genetic and environmental factors are known to contribute to the pathogenesis of the disease. ...
Construction of human anti-tetanus single-chain variable fragment applying SYMPLEX technology [0.03%]
应用SYMPLEX技术构建人源抗破伤风单链抗体片段基因单元库
Laya Esmati,Jalil Fallah Mehrabadi,Masoumeh Bazaz et al.
Laya Esmati et al.
Background: Human monoclonal antibodies are important molecules in clinical research. Current Limitations of mAb technologies namely instability of immortalized B-cell line and probability of forming unusual VH-VL pairs i...
Down-regulation of CYP27B1 gene expression in Iranian patients with relapsing-remitting multiple sclerosis [0.03%]
伊朗复发缓解型多发性硬化症患者CYP27B1基因表达下调
Zahra Rezaie,Mohammad Taheri,Leila Kohan et al.
Zahra Rezaie et al.
Background: Multiple sclerosis (MS) as a complex neurological disease can be due to vitamin D deficiency. CYP27B1 is referred to as a vitamin D metabolizing enzyme. ...
Increased expression ratio of matrix metalloproteinase-9 (MMP9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) RNA levels in Iranian multiple sclerosis patients [0.03%]
伊朗多发性硬化患者的基质金属蛋白酶-9(MMP9)和基质金属蛋白酶抑制物(TIMP-1)RNA表达水平增加
Marzieh Khoshbin Nazdik,Mohammad Taheri,Elham Sajjadi et al.
Marzieh Khoshbin Nazdik et al.
Objectives: Multiple sclerosis (MS) is an autoimmune disease involving the central nervous system (CNS) with unknown immunopathogenic mechanisms. Matrix metalloproteinase-9 (MMP-9) facilitates T-cell migration into the CN...