Isolation and characterization of anti ROR1 single chain fragment variable antibodies using phage display technique [0.03%]
噬菌体展示技术筛选抗ROR1单链抗体片段及鉴定
Leili Aghebati-Maleki,Vahid Younesi,Farhad Jadidi-Niaragh et al.
Leili Aghebati-Maleki et al.
Receptor tyrosine kinase-like orphan receptor (ROR1) belongs to one of the families of receptor tyrosine kinases (RTKs). RTKs are involved in the various physiologic cellular functions including proliferation, migration, survival, signaling...
Suppression of tumor growth by a heterologous antibody directed against multiple myeloma dominant CD38 antigen in SCID mice injected with multiple myeloma cells [0.03%]
用异源抗体在接种多发性骨髓瘤细胞的SCID小鼠中抑制肿瘤生长
Arpad Z Barabas,Chad D Cole,Richard M Graeff et al.
Arpad Z Barabas et al.
Employing passive immunization - using a heterologous anti-CD38 IgG antibody containing serum - in SCID mice injected subcutaneously with human multiple myeloma cells, we have shown that treatments with the antiserum - especially in the pre...
A novel modified vaccination technique produces IgG antibodies that cause complement-mediated lysis of multiple myeloma cells carrying CD38 antigen [0.03%]
一种新型疫苗技术可产生IgG抗体 激活补体介导CD38抗原阳性多发性骨髓瘤细胞的裂解
Arpad Z Barabas,Chad D Cole,Richard M Graeff et al.
Arpad Z Barabas et al.
Objectives were to: 1) induce a lytic IgG antibody (ab) response (via the so called `third vaccination method') against CD38 antigen (ag) residing on the extra-cellular domain of multiple myeloma (MM) cells in recipient rabbits, by combinin...
The effect of Intravenous Immunoglobulin (IVIG) on /textit{ex vivo} activation of human leukocytes [0.03%]
静脉注射免疫球蛋白对人白细胞体外激活的影响
Liliya Yu Basyreva,Ilya B Brodsky,Alexander A Gusev et al.
Liliya Yu Basyreva et al.
Introduction: Intravenous immunoglobulin (IVIG) has been widely used to treat various conditions, including inflammatory and autoimmune diseases. IVIG has been shown to have a direct influence on neutrophils, eosinophils ...
Up regulation of MMP9 gene expression in female patients with multiple sclerosis [0.03%]
女性多发性硬化症患者的基质金属蛋白酶9基因表达的上调
Shima Yazdandoost Hamedani,Mohammad Taheri,Elham Sajjadi et al.
Shima Yazdandoost Hamedani et al.
Background: Multiple sclerosis (MS) is an inflammatory, immune-mediated, demyelinating disease of the central nervous system which disturbs cerebral vascular permeability. ...
Curing tumor-bearing mice by shifting a Th2 to a Th1 anti-tumor response [0.03%]
通过从Th2型向Th1型抗肿瘤反应的转变治愈荷瘤小鼠
Karl Erik Hellstrom,Min Dai,Ingegerd Hellstrom
Karl Erik Hellstrom
Over the past several years remarkable therapeutic responses have been obtained with immunomodulatory monoclonal antibodies (mAbs), both in mice /cite{10,18,20,48,54,61} and human cancer patients /cite{1,3,14,28,30,39,80}. However, complete...
Harnessing co-stimulatory TNF receptors for cancer immunotherapy: Current approaches and future opportunities [0.03%]
癌症免疫治疗中协同刺激性TNF受体的运用：当前方法与未来机遇
Jeremy D Waight,Randi B Gombos,Nicholas S Wilson
Jeremy D Waight
Co-stimulatory tumor necrosis factor receptors (TNFRs) can sculpt the responsiveness of T cells recognizing tumor-associated antigens. For this reason, agonist antibodies targeting CD137, CD357, CD134 and CD27 have received considerable att...
The paired receptors TIGIT and DNAM-1 as targets for therapeutic antibodies [0.03%]
TIGIT和DNAM-1配对受体作为治疗性抗体的作用靶点
Natan Stein,Pinchas Tsukerman,Ofer Mandelboim
Natan Stein
One of the most exciting fields in modern medicine is immunotherapy, treatment which looks to harness the power of the immune system to fight disease. A particularly effective strategy uses antibodies designed to influence the activity leve...
Modulators of IgG penetration through the blood-brain barrier: Implications for Alzheimer's disease immunotherapy [0.03%]
调节IgG穿过血脑屏障的物质：阿尔茨海默病免疫治疗的启示
John M Finke,William A Banks
John M Finke
This review serves to highlight approaches that may improve the access of antibody drugs to regions of the brain affected by Alzheimer's Disease. While previous antibody drugs have been unsuccessful in treating Alzheimer's disease, recent w...