TNF-α -308G/A gene polymorphism in bullous pemphigoid and alopecia areata [0.03%]
肿瘤坏死因子-α-308G/A基因多态性与大疱性类天疱疮和斑秃的关系
Hamideh Moravvej,Pardis-Sadat Tabatabaei-Panah,Elaheh Ebrahimi et al.
Hamideh Moravvej et al.
Background: TNF-α -308G/A polymorphism has been investigated in few studies for an association with susceptibility to bullous pemphigoid (BP) and alopecia areata (AA). Yet, these findings had so far not been independentl...
Pneumococcal disease burden, clinical presentations and vaccine coverage in the Jamaican population [0.03%]
肺炎球菌疾病负担、临床表现及疫苗接种覆盖率的牙买加人口研究
R Willis,O Heslop,N Bodonaik et al.
R Willis et al.
Background: Pneumococcal serotypes circulating in any population vary over time and between countries and impacts the effectiveness of pneumococcal vaccination. ...
Xenia Wezler,Stefan Dübel,Thomas Schirrmann
Xenia Wezler
ImmunoRNases combine tumor targeting by antibodies with the cytotoxic action of ribonucleases from the RNase A superfamily. This study investigated for the first time all catalytic active human RNase A family members (1 to 8) as effector co...
Production and characterization of anti-human IgG F(ab')2 antibody fragment [0.03%]
人IgGF（ab'）2抗体片段的产生及鉴定
Zahra Valedkarimi,Hadi Nasiri,Leili Aghebati-Maleki et al.
Zahra Valedkarimi et al.
In present study an optimized protocol for the separation of antibodies into antigen-binding fragments F(ab')2 using pepsin digestion was investigated. The production of these fragments is a consequential step in the development of medical ...
Evaluation of antibodies to cytomegalovirus and Epstein-Barr virus in patients with autism spectrum disorder [0.03%]
自闭症谱系障碍患者人巨细胞病毒和Epstein-Barr病毒抗体的评价研究
Shahla Valayi,Mohammad Mahdi Eftekharian,Mohammad Taheri et al.
Shahla Valayi et al.
Autism is a neurodevelopmental disease that manifested by a wide range of behavioral disorders. Although the etiology of autism is remained unknown but it is suggested that ASD have a complex etiology, including genetic and environmental fa...
FOXP3 gene expression in the blood of Iranian multiple sclerosis patients [0.03%]
伊朗多发性硬化症患者外周血中FOXP3基因表达的研究
Zahra Akbari,Mohammad Taheri,Abdorreza Jafari et al.
Zahra Akbari et al.
Introduction: Multiple sclerosis (MS) is a heterogeneous disease with an unknown etiology. Both genetic and environmental factors lead to MS disease. Recent studies have revealed the inhibitory role of T regulatory cells ...
Cost-effective batch production process of scFv antibody in Escherichia coli [0.03%]
一种在大肠杆菌中高效低成本生产单链抗体(scFv)的工艺方法
Ali Mesgari-Shadi,Mohammad-Hossein Sarrafzadeh,Jaleh Barar et al.
Ali Mesgari-Shadi et al.
Background: Cost-effective production of antibody (Ab) fragments is of great interests of many pharmaceutical industries, in large part due to their high usages in research, diagnosis and therapy. Thus, the production of ...
Polymorphism FSHR (-29G/A) as a genetic agent together with ESRI (XbaIG/A) in women with poor response to controlled ovarian hyperstimulation [0.03%]
多态性FSHR(-29G/A)与ESRI(XbaI/G/A)作为遗传因素在控制卵巢过度刺激反应不良妇女中的作用
Tannaz Zamaniara,Robabeh Taheripanah,Sayyed Mohammad Hossein Ghaderian et al.
Tannaz Zamaniara et al.
Background: One of the major problems in IVF is the poor response of the ovary to gonadotropins. ESRI and FSHR are two effective genes on controlled ovarian hyperstimulation (COH). ...
Knowledge, attitude, and practice of HIV/AIDS among workers at China first highway engineering Company at Bilibila Sokota Road Project, Sokota, Ethiopia [0.03%]
关于埃塞俄比亚索科特塔比利比拉公路项目中国路桥工程有限责任公司员工艾滋病知识、态度和行为的调查研究报告
Mebratu Tarekegne,Addis Adera,Kalab Haile et al.
Mebratu Tarekegne et al.
Objective: The aim of this study was to assess Bilbila Sokota Road Project workers' knowledge, attitude and practice on HIV/AIDS in China first highway engineering Company. ...
Of patents and patent disputes - The TNFα patent files. Part 2: Enbrel, Remicade, Cimzia and Simponi [0.03%]
关于专利及其纠纷之二——TNFα专利档案：恩利、类克、欣普尼和强克
Ulrich Storz
Ulrich Storz
This article is the second part of a trilogy that discusses IP issues related to anti-Tumor Necrosis factor α (TNFα) biologics. TNFα is the world's most valuable target, with accumulated sales of TNFα biologics of 34 bn USD in 2014. Whi...