Neoantigen: A Promising Target for the Immunotherapy of Colorectal Cancer [0.03%]
neoantigen：结直肠癌免疫治疗的新靶点
Yue Zheng,Yang Fu,Pei-Pei Wang et al.
Yue Zheng et al.
At present, there are various treatment strategies for colorectal cancer, including surgery, chemotherapy, radiotherapy, and targeted therapy. In recent years, with the continuous development of immunotherapy, immune checkpoint inhibitors (...
IDH1 Mutation Induces HIF-1 α and Confers Angiogenic Properties in Chondrosarcoma JJ012 Cells [0.03%]
IDH1突变诱导软骨肉瘤JJ012细胞HIF-1α表达并促使其获得血管生成表型
Xiaoyu Hu,Luyuan Li,Josiane E Eid et al.
Xiaoyu Hu et al.
Chondrosarcoma is a group of primary bone cancers that arise from transformed cells of chondrocytic lineage. Tumor recurrence and metastasis are devastating for patients with chondrosarcoma since there are no effective treatment options. ID...
Effects of Hemodialysis on Intraocular Pressure and Ocular Biological Parameters in Different Angle Structures [0.03%]
血液透析对不同房角结构眼内压及眼部生物参数的影响
Fenglei Wang,Ling Wang,Zhiying Yu et al.
Fenglei Wang et al.
Purpose: This study is aimed at evaluating the effects of hemodialysis on intraocular pressure (IOP) and exploring the possible factors affecting IOP. Met...
LC-MS-Based Lipidomic Analysis of Serum Samples from Patients with Type 2 Diabetes Mellitus (T2DM) [0.03%]
基于LC-MS的T2DM患者血清脂质组分析
Jia Liu,Lu Bai,Weimin Wang et al.
Jia Liu et al.
Background: With the development of social economy, type 2 diabetes mellitus (T2DM) is becoming a severe health problem globally. Methods: ...
Bioinformatic Analysis and Cellular Assays Identify Substance P Influencing Th17/Treg Differentiation via the MyD88 Pathway as a Potential Contributor to the Progression of Asthma and Allergic Rhinitis [0.03%]
生物信息学分析和细胞检测确定缓激肽通过MyD88途径影响Th17/Treg分化为哮喘和过敏性鼻炎的进展做出潜在贡献
Yuemei Ma,Chang Liu,Guangpeng Xi et al.
Yuemei Ma et al.
Objective: This study is aimed at investigating the role of substance P (SP) in the development of asthma. Methods: The Gene Expression...
Overexpression of CAPG Is Associated with Poor Prognosis and Immunosuppressive Cell Infiltration in Ovarian Cancer [0.03%]
CAPG过表达与卵巢癌预后不良和免疫抑制性细胞浸润相关
Senwei Jiang,Yuebo Yang,Yu Zhang et al.
Senwei Jiang et al.
Historically, immunotherapies have only resulted in a partial response from patients with advanced ovarian cancer, resulting in poor clinical efficacy. A full understanding of immune-related gene expression and immunocyte infiltration in ov...
Serum Exosomal lncRNA AC007099.1 Regulates the Expression of Neuropeptide-Related FAP, as a Potential Biomarker for Hepatocarcinogenesis [0.03%]
血清外泌体长链非编码RNA AC007099.1调控神经肽相关原癌基因FAP的表达，作为肝细胞癌发生发展的潜在生物标志物
Luqian Li,Fei Xiao,Guolian Liu et al.
Luqian Li et al.
Neuropeptide-associated fibroblast activation protein (FAP) may be an important risk factor for neurovascular metastasis in hepatocellular carcinoma. Analysis of The Cancer Genome Atlas (TCGA) database showed that FAP mRNA was highly expres...
Iman Razeghian-Jahromi,Ali Karimi Akhormeh,Mohammad Javad Zibaeenezhad
Iman Razeghian-Jahromi
There is a huge number of noncoding RNA (ncRNA) transcripts in the cell with important roles in modulation of different mechanisms. ANRIL is a long ncRNA with 3.8 kb length that is transcribed in the opposite direction of the INK4/ARF locus...
The Neuronal Transcription Factor Creb3l1 Potential Upregulates Ntrk2 in the Hypertensive Microenvironment to Promote Vascular Smooth Muscle Cell-Neuron Interaction and Prevent Neurons from Ferroptosis: A Bioinformatic Research of scRNA-seq Data [0.03%]
高血压微环境中神经元转录因子Creb3l1 Potential通过上调Ntrk2促进血管平滑肌细胞-神经元相互作用并防止神经元铁死亡的 bioinformatics研究：基于scRNA-seq数据
Xiaoyu Zhao,Jie Yang,Chuanhua Yang
Xiaoyu Zhao
Background: There is still a lack of knowledge regarding the association between hypertension and ferroptosis. A single-cell approach was used to study the changes in neuropeptide expression as they might contribute to th...
Identification of Synovial Fibroblast-Associated Neuropeptide Genes and m6A Factors in Rheumatoid Arthritis Using Single-Cell Analysis and Machine Learning [0.03%]
利用单细胞分析和机器学习识别类风湿关节炎滑膜成纤维细胞相关神经肽基因及m６A修饰因子
Jianwei Xiao,Xu Cai,Rongsheng Wang et al.
Jianwei Xiao et al.
Objectives: Synovial fibroblasts (SFs) play an important role in the development and progression of rheumatoid arthritis (RA). However, the pathogenic mechanism of SFs remains unclear. The objective of this study was to i...