Psychedelic-assisted therapies for existential and spiritual suffering in palliative care [0.03%]
辅助治疗临终关怀中的存在主义和精神痛苦的迷幻疗法
Ana Cláudia Mesquita Garcia,Lucas Oliveira Maia
Ana Cláudia Mesquita Garcia
Existential and spiritual suffering are frequently reported by individuals facing serious illnesses, particularly at the end of life, and are associated with diminished quality of life, increased psychological distress, and requests for has...
Chemical diversity, receptor binding affinity, and pharmacology of phytocannabinoids: Insights into neuronal mechanisms [0.03%]
植物大麻素的化学多样性、受体结合亲和力和药理学：对神经机制的新见解
Claudio Marcos Queiroz,Laura de Oliveira Koren,Camila Rayane Pereira da Silva et al.
Claudio Marcos Queiroz et al.
Comparative studies of phytocannabinoids offer valuable insights into the therapeutic potential of cannabis. While Cannabis sativa can produce over 100 distinct phytocannabinoids, most are present only in trace amounts. This review examines...
Elisa Mitiko Kawamoto,Cristoforo Scavone,Rosana Camarini
Elisa Mitiko Kawamoto
Bianca Andrade Rodrigues,Thays Calista Santiago Pretes,Josiane do Nascimento Silva
Bianca Andrade Rodrigues
Changes in energy homeostasis in aging have significant implications for brain health. Decreased glucose utilization efficiency, mitochondrial dysfunction, loss of metabolic flexibility, and increased oxidative stress can compromise cogniti...
Carmen Vivar,Lazaro P Orihuela,Grego Apostol
Carmen Vivar
Exercise has been central to human brain evolution. Genus Homo was a nomadic species that constantly explored novel environments, which requires the encoding of new spatial and contextual patterns and the consolidation and recall of details...
Geovana Rosa Oliveira Dos Santos,Thiago Amorim de Souza Lima,Merle Gallus et al.
Geovana Rosa Oliveira Dos Santos et al.
Intermittent fasting (IF) is a dietary intervention based on time-restricted energy intake. Over the years, IF has been widely investigated as a non-pharmacological approach to increasing life expectancy and promoting brain health. The unde...
Glaucia Maria Machado-Santelli,Julyane Batista Chaves
Glaucia Maria Machado-Santelli
Hormesis, the processes in which small doses of a stressor show stimulatory effects or protective responses on target cells, and high doses show the opposite effects, was described as associated with cancer therapy. Although the introductio...
Robbert Mota Pereira,Kairo Alan Albernaz-Mariano,Paloma Marinho Jucá et al.
Robbert Mota Pereira et al.
This chapter explores sex-specific differences in brain development and hormones' critical role throughout life. Understanding these variabilities is vital for mental health, particularly concerning stress responses, aging, and the risk of ...
Hormesis-induced neuroplasticity: Targeting neuroinflammation signaling cascades for therapeutic insights in aging and neurodegenerative diseases [0.03%]
低剂量毒性刺激引起的神经可塑性：靶向炎症信号通路以治疗衰老和神经退行性疾病
Thays Calista Santiago Pretes,Cristoforo Scavone
Thays Calista Santiago Pretes
The signaling pathways associated with α-Klotho, glutamate, mediators of the inflammatory response in the central nervous system (CNS) and that related to different isoforms of the Na, K-ATPase (NKA) protein as a pump and receptor for endo...
Vernise J T Lim,Nishat I Tabassum,Jacqueline M Orian et al.
Vernise J T Lim et al.
Hormesis, the concept that low doses of potentially harmful stressors can elicit adaptive, beneficial effects, plays a significant role in brain health and aging. Neurohormesis refers to the adaptive response of neurons to mild stress, acti...