Paving the Way to Personalized Genomic Medicine: Steps to Successful Implementation [0.03%]
走向个性化基因组医学之路：成功实施的步骤
Jennifer L Fackler,Amy L McGuire
Jennifer L Fackler
Over the last decade there has been vast interest in and focus on the implementation of personalized genomic medicine. Although there is general agreement that personalized genomic medicine involves utilizing genome technology to assess ind...
GENETIC VARIATION IN THE β(2)-ADRENERGIC RECEPTOR: IMPACT ON INTERMEDIATE CARDIOVASCULAR PHENOTYPES [0.03%]
β-肾上腺素能受体基因多态性与中间型心血管表型的关系研究
C Hesse,J H Eisenach
C Hesse
Genetic variation in drug targets (e.g. receptors) can have pronounced effects on clinical responses to endogenous and exogenous agonists. Polymorphisms in the gene encoding the β(2)-adrenergic receptor (β(2)-AR) have been associated with...
The Pathway Less Traveled: Moving from Candidate Genes to Candidate Pathways in the Analysis of Genome-Wide Data from Large Scale Pharmacogenetic Association Studies [0.03%]
鲜少人问津的道路——从候选基因到候选通路：大规模药物基因组关联研究中全基因组数据的分析
R A Wilke,R K Mareedu,J H Moore
R A Wilke
The candidate gene approach to pharmacogenetics is hypothesis driven, and anchored in biological plausibility. Whole genome scanning is hypothesis generating, and it may lead to new biology. While both approaches are important, the scientif...
Do Estrogen Receptor beta Polymorphisms Play A Role in the Pharmacogenetics of Estrogen Signaling? [0.03%]
雌激素受体β多态性在雌激素信号传导的药理遗传学中起作用吗？
Stephanie L Nott,Yanfang Huang,Brian R Fluharty et al.
Stephanie L Nott et al.
Estrogen hormones play critical roles in the regulation of many tissue functions. The effects of estrogens are primarily mediated by the estrogen receptors (ER) alpha and beta. ERs are ligand-activated transcription factors that regulate a ...