Statistical Optimization of Pharmacogenomics Association Studies: Key Considerations from Study Design to Analysis [0.03%]
药理基因组关联研究的统计优化：从试验设计到分析的关键考虑因素
Benjamin J Grady,Marylyn D Ritchie
Benjamin J Grady
Research in human genetics and genetic epidemiology has grown significantly over the previous decade, particularly in the field of pharmacogenomics. Pharmacogenomics presents an opportunity for rapid translation of associated genetic polymo...
Alternatively Spliced Genes as Biomarkers for Schizophrenia, Bipolar Disorder and Psychosis: A Blood-Based Spliceome-Profiling Exploratory Study [0.03%]
精神分裂症、双相情感障碍和精神病的备选剪切基因生物标志物：基于血液的剪接组谱分析探索性研究
S J Glatt,S D Chandler,C A Bousman et al.
S J Glatt et al.
OBJECTIVE: Transcriptomic biomarkers of psychiatric diseases obtained from a query of peripheral tissues that are clinically accessible (e.g., blood cells instead of post-mortem brain tissue) have substantial practical appeal to discern the...
Asia-Pacific Health 2020 and Genomics without Borders: Co-Production of Knowledge by Science and Society Partnership for Global Personalized Medicine [0.03%]
2020年亚太地区健康大会和跨越边界的基因组学：科学与社会合作推动全球精准医疗的发展
Vural Ozdemir,David H Muljono,Tikki Pang et al.
Vural Ozdemir et al.
Nutriproteomics and Proteogenomics: Cultivating Two Novel Hybrid Fields of Personalized Medicine with Added Societal Value [0.03%]
营养蛋白质组学和蛋白基因组学：培养两种具有额外社会价值的精准医疗新型交叉学科
Vural Ozdemir,Jean Armengaud,Laurette Dubé et al.
Vural Ozdemir et al.
Genetic Variations in Telomere Maintenance, with Implications on Tissue Renewal Capacity and Chronic Disease Pathologies [0.03%]
端粒维持的遗传多态性及其对组织更新能力及慢性疾病病理的影响研究
M A Trudeau,J M Y Wong
M A Trudeau
Premature loss of telomere repeats underlies the pathologies of inherited bone marrow failure syndromes. Over the past decade, researchers have mapped genetic lesions responsible for the accelerated loss of telomere repeats. Haploinsufficie...
Cannabidiol As a Putative Novel Therapy for Diabetic Retinopathy: A Postulated Mechanism of Action as an Entry Point for Biomarker-Guided Clinical Development [0.03%]
大麻二酚作为糖尿病视网膜病的潜在新疗法：以生物标志物为指导的临床研发的作用机制探讨
Gi Liou,Ab El-Remessy,As Ibrahim et al.
Gi Liou et al.
Diabetic retinopathy is a leading cause of blindness in the Western world. However, treatment options for diabetic retinopathy are limited and display poor efficacy with marked patient-to-patient variation in therapeutic outcomes. Discovery...
Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation [0.03%]
饮食、环境和职业化学物质激活CAR和PXR改变药物代谢、中间代谢及细胞增殖
J P Hernandez,L C Mota,W S Baldwin
J P Hernandez
The constitutive androstane receptor (CAR) and the pregnane × receptor (PXR) are activated by a variety of endogenous and exogenous ligands, such as steroid hormones, bile acids, pharmaceuticals, and environmental, dietary, and occupationa...
Personalized Medicine Beyond Genomics: New Technologies, Global Health Diplomacy and Anticipatory Governance [0.03%]
超越基因组学的个性化医学：新技术、全球卫生外交与预见性治理
V Ozdemir,D Husereau,S Hyland et al.
V Ozdemir et al.
Personalizing Stem Cell Research and Therapy: The Arduous Road Ahead or Missed Opportunity? [0.03%]
个性化干细胞研究与治疗：前方的艰难之路还是错失的机遇？
S A Patel,C C King,P K Lim et al.
S A Patel et al.
The euphoria of stem cell therapy has diminished, allowing scientists, clinicians and the general public to seriously re-examine how and what types of stem cells would effectively repair damaged tissue, prevent further tissue damage and/or ...
Personalizing HER2-targeted therapy in metastatic breast cancer beyond HER2 status: what we have learned from clinical specimens [0.03%]
转移性乳腺癌HER2靶向治疗的个体化选择：临床标本告诉我们的故事（超越HER2状态）
R Nahta,S Shabaya,T Ozbay et al.
R Nahta et al.
HER2 is over-expressed in approximately 25% to 30% of human metastatic breast cancers, primarily due to gene amplification. There are currently two HER2-targeted therapies approved for clinical use, the monoclonal HER2 antibody trastuzumab ...