Leptin-Induced Sympathetic Nerve Activation: Signaling Mechanisms and Cardiovascular Consequences in Obesity [0.03%]
瘦素诱导的交感神经激活：肥胖中的信号机制和心血管后果
Kamal Rahmouni
Kamal Rahmouni
Obesity increases cardiovascular morbidity and mortality in part by inducing hypertension. One factor linking excess fat mass to cardiovascular diseases may be the sympathetic cardiovascular actions of leptin. Initial studies of leptin show...
Mingyi Wang,Benjamin Khazan,Edward G Lakatta
Mingyi Wang
Arterial remodeling over time is a cornerstone of normal systemic aging. The age-associated arterial structural and functional changes in the intima, the media, and the adventitia are closely linked to angiotensin II (Ang II) signaling. A g...
Research into Specific Modulators of Vascular Sex Hormone Receptors in the Management of Postmenopausal Cardiovascular Disease [0.03%]
特异性血管性激素受体调节剂在绝经后心血管疾病治疗中研究进展
Graciliano R A do Nascimento,Yaskara V R Barros,Amanda K Wells et al.
Graciliano R A do Nascimento et al.
Cardiovascular disease (CVD) is more common in men and postmenopausal women than premenopausal women, suggesting vascular benefits of female sex hormones. Studies on the vasculature have identified estrogen receptors ERα, ERβ and a novel ...
Role of Reactive Oxygen Species in Tumor Necrosis Factor-alpha Induced Endothelial Dysfunction [0.03%]
活性氧在肿瘤坏死因子-α诱导的内皮细胞功能障碍中的作用
Xiuping Chen,Bradley T Andresen,Michael Hill et al.
Xiuping Chen et al.
Endothelial cell injury and dysfunction are the major triggers of pathophysiological processes leading to cardiovascular disease. Endothelial dysfunction (ED) has been implicated in atherosclerosis, hypertension, coronary artery disease, va...
Zhongjian Cheng,Xiaofeng Yang,Hong Wang
Zhongjian Cheng
Hyperhomocysteinemia (HHcy) is a significant and independent risk factor for cardiovascular diseases. Endothelial dysfunction (ED) is the earliest indicator of atherosclerosis and vascular diseases. We and others have shown that HHcy induce...
Silent Partner in Blood Vessel Homeostasis? Pervasive Role of Nitric Oxide in Vascular Disease [0.03%]
幕后合作伙伴？一氧化氮在血管疾病中的广泛作用
Ruba S Deeb,Brian D Lamon,David P Hajjar
Ruba S Deeb
The endothelium generates powerful mediators that regulate blood flow, temper inflammation and maintain a homeostatic environment to prevent both the initiation and progression of vascular disease. Nitric oxide (NO) is arguably the single m...
Yuri Ozawa,Koichi Hayashi,Hiroyuki Kobori
Yuri Ozawa
During a couple of decades, a number of antihypertensive drugs have been developed, and the choice of hypertension treatment has been expanded. Among antihypertensive drugs, calcium channel blockers, which inhibit L-type voltage-gated calci...
Yuki Suzaki,Minolfa C Prieto-Carrasquero,Hiroyuki Kobori
Yuki Suzaki
It is well recognized that the renin-angiotensin system plays an important role in the regulation of arterial pressure and sodium homeostasis. Recent years, many studies have shown that local tissue angiotensin II levels are differentially ...
Transdermal Drug Delivery System (TDDS) is one of the controlled drug delivery sys-tems whose purpose is to deliver medication through the skin at a predetermined and regulated rate. Nanotechnology has enhanced the skin's absorption of lipo...