Unravelling the Mechanistic Role of ACE2 and TMPRSS2 in Hypertension: A Risk Factor for COVID-19 [0.03%]
ACE2和TMPRSS2在高血压中的作用机制解析：COVID-19的危险因素
Nalini Govender,Olive Khaliq,Jagidesa Moodley et al.
Nalini Govender et al.
Background: This review explores the mechanistic action of angiotensin-converting enzyme- 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) in the renin-angiotensinaldosterone system (RAAS) that predisposes hypertens...
Treatment with Cannabidiol Results in an Antioxidant and Cardioprotective Effect in Several Pathophysiologies [0.03%]
大麻二醇的治疗在病理生理学中具有抗氧化性和心脏保护作用
Natasha M C Oliveira,Dayane A Machado,Thauann L da Silva et al.
Natasha M C Oliveira et al.
Cannabis sativa has chemically active compounds called cannabinoids, where Δ9- tetrahydrocannabinol (THC) and Cannabidiol (CBD) are the major ones responsible for the various pharmacological effects. The endocannabinoid system is an endoge...
Leandro Bueno Bergantin
Leandro Bueno Bergantin
Circulatory and Placental Expression of Soluble Fms-like Tyrosine Kinase- 1 and Placental Growth Factor in HIV-infected Preeclampsia [0.03%]
HIV感染子痫前症中循环和胎盘可溶性FMS样酪氨酸激酶-1和胎盘生长因子的表达
Zinhle P Mlambo,Olive P Khaliq,Jagidesa Moodley et al.
Zinhle P Mlambo et al.
An imbalance between angiogenic and anti-angiogenic factors plays a fundamental role in the pathogenesis of preeclampsia (PE). Studies have shown a dysregulation of sFlt-1 and placental growth factor (PlGF) in PE. However, there are differi...
Arthur C Francisco,Wanessa M C Awata,Thauann S Lima et al.
Arthur C Francisco et al.
The efficiency of blood flowing from the heart depends on its electrical properties. Myocardial electrical activity is associated with generating cardiac action potentials in isolated myocardial cells and their coordinated propagation, whic...
Gulam Navi Azad,Anoop Kumar
Gulam Navi Azad
The practice of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (ACEi/ARB) in COVID-19 hypertensive patients is still an open question for clinicians to answer. The present study was conducted to find out the assoc...
Impaired Fasting Glucose (IFG) Prevalence Among Hypolipidemic Treatment- naïve Patients with Hypertension [0.03%]
高血压未使用降脂药物治疗患者的空腹血糖受损(IFG)患病率
John Papadakis,Petros Ioannou,George Vrentzos et al.
John Papadakis et al.
Background: Impaired fasting glucose (IFG) predisposes to the future development of type 2 diabetes mellitus (T2DM) and may also be associated with increased cardiovascular disease (CVD) risk. Hypertension is an establish...
Hormone-Dependent Regulation of Renin and Effects on Prorenin Receptor Signaling in the Collecting Duct [0.03%]
激素依赖性调节肾素及对集合管中前肾素受体信号传导的影响
Lucienne S Lara,Alexis A Gonzalez,Matthew T Hennrikus et al.
Lucienne S Lara et al.
The production of renin by the principal cells of the collecting duct has widened our understanding of the regulation of intrarenal angiotensin II (Ang II) generation and blood pressure. In the collecting duct, Ang II increases the synthesi...
Kellea Nichols,Frederique Yiannikouris
Kellea Nichols
The prorenin receptor (PRR) is a complex multi-functional single transmembrane protein receptor that is ubiquitously expressed in organs and tissues throughout the body. PRR is involved in different cellular mechanisms that comprise the gen...
(Pro)renin Receptor and Blood Pressure Regulation: A Focus on the Central Nervous System [0.03%]
促肾素受体与血压调节：中枢神经系统研究为重点
Lucas A C Souza,Yumei Feng Earley
Lucas A C Souza
The renin-angiotensin system (RAS) is classically described as a hormonal system in which angiotensin II (Ang II) is one of the main active peptides. The action of circulating Ang II on its cognate Ang II type-1 receptor (AT1R) in circumven...