The biological and clinical activity of anti-malarial drugs in autoimmune disorders [0.03%]
抗疟药在自身免疫疾病中的生物和临床活性
Elham Taherian,Anshul Rao,Charles J Malemud et al.
Elham Taherian et al.
Chloroquine and hydroxychloroquine are 4-aminoquinoline compounds commonly employed as anti-malarial drugs. Chloroquine and its synthetic analogue, hydroxychloroquine also belong to the disease-modifying anti-rheumatic drug class because th...
Pavel Horak,Martina Skacelova,Josef Zadrazil et al.
Pavel Horak et al.
SLE is characterized by overproduction of various types of autoantibodies. Under certain circumstances, antibodies targeting some of the neoepitopes of the complement system can be seen. The most studied among antibodies directed against a ...
Alexander P Rozin
Alexander P Rozin
The interventional studies with bone biopsy of the SAPHO lesions and microbiological investigation are a significant addition to a long range of publications showing an association of SAPHO with Propionibacterium acnes. Infectious agents is...
Matteo Colina,Francesco Trotta
Matteo Colina
The peculiar bone involvement, represented by osteitis, is the common denominator of SAPHO syndrome. Hyperostosis and osteitis are chronic inflammatory reactions involving the cortical and trabecular bone respectively; both are characterise...
Henner Morbach,Hermann J Girschick
Henner Morbach
The clinical picture of childhood chronic recurrent multifocal osteomyelitis (CRMO) is characterized by an aseptic chronic osteomyelitis, most often affecting the metaphyses of the long bones. Skin inflammation (palmoplantar pustulosis, pso...
Hans Kohler
Hans Kohler
In the early seventies isolated Sternocostoclavicular Hyperostosis (SCCH) was described as a persistent painful swelling of the sternum, clavicles and upper ribs. A few years later associations with skin lesions were reported and SCCH was s...
The immune response in SAPHO syndrome: deficiency, hyper- responsiveness, or both? [0.03%]
SAPHO综合征的免疫反应：缺陷、超敏或两者兼有？
Gilles Hayem,Margarita Hurtado-Nedelec,Sylvie Chollet-Martin
Gilles Hayem
The pathophysiology of SAPHO syndrome still remains to be determined. However, like in other forms of spondylarthritides, this rare condition seems to result from the combination of genetic, environmental and immunological factors. Surely, ...
Frank A Wollheim
Frank A Wollheim
SAPHO and its relative CMRO are uncommon but not rare chronic conditions with unknown etiology. Environmental factors, perhaps related to microorganisms, may be important triggers, but there is no support for a septic nature. The monogenic ...
Psoriasis vulgaris and psoriasis pustulosa - epidemiology, quality of life, comorbidities and treatment [0.03%]
寻常型银屑病和脓疱型银屑病的流行病学、生活质量、共病及治疗研究
Claudia Pfohler,Cornelia S L Muller,Thomas Vogt
Claudia Pfohler
The prevalence of psoriasis is 2-3% in European Countries, therefore psoriasis is one of the most frequently occurring inflammatory skin diseases. Psoriasis results from an interaction of genetic factors and environmental conditions such as...
Gunter Assmann
Gunter Assmann
To talk about SAPHO syndrome means to discuss its entity. It is a great honour to me as guest editor to greet you and to present to you the following scientific articles dealing with different aspects of the SAPHO syndrome. We are pleased t...