The canine blood-brain barrier in health and disease: focus on brain protection [0.03%]
健康与疾病状态下的犬类血脑屏障：侧重于大脑保护
Dimitri Bassalo,Stephen G Matthews,Enrrico Bloise
Dimitri Bassalo
This review examines the role of the canine blood-brain barrier (BBB) in health and disease, focusing on the impact of the multidrug resistance (MDR) transporter P-glycoprotein (P-gp) encoded by the ABCB1/MDR1 gene. The BBB is critical in m...
Development of a differentiating of infected from vaccinated animal (DIVA) ELISA to detect antibodies against Senecavirus A in pigs using two expression systems of non-structural proteins [0.03%]
基于两种非结构蛋白表达体系的检测感染猪SVA抗体的区分疫接种DIVA酶免方法的建立与发展
Parin Watcharavongtip,Patumporn Jermsutjarit,Angkana Tantituvanont et al.
Parin Watcharavongtip et al.
Senecavirus A (SVA) is the causative agent associated with porcine idiopathic vesicular disease (PIVD), a condition indistinguishable from other foreign vesicular diseases affecting pigs. This complicates differential diagnosis and impacts ...
Isatidis root polysaccharides ameliorates post-weaning diarrhea by promoting intestinal health and modulating the gut microbiota in piglets [0.03%]
板蓝根多糖通过促进肠道健康和调节肠道微生物群来改善断奶仔猪腹泻
Miao Zhou,Zenghao Yan,Deqin Wang et al.
Miao Zhou et al.
This study aimed to investigate the effects of dietary isatidis root polysaccharide (IRP) on diarrhea, immunity, and intestinal health in weanling piglets. Forty healthy piglets were randomly assigned to five groups receiving varying dosage...
Metabolomics reveals alterations in gut-derived uremic toxins and tryptophan metabolism in feline chronic kidney disease [0.03%]
代谢组学揭示了猫慢性肾脏疾病中肠道衍生的尿毒症毒素和色氨酸代谢的改变
Laurens Van Mulders,Ellen Vanden Broecke,Ellen De Paepe et al.
Laurens Van Mulders et al.
Chronic Kidney Disease (CKD) is one of the most common conditions affecting felines, yet the metabolic alterations underlying its pathophysiology remain poorly understood, hindering progress in identifying biomarkers and therapeutic targets...
Supplemental glucose oxidase as an antibiotic substitute alleviates diarrhea and improves intestinal health in weaned piglets [0.03%]
葡萄糖氧化酶作为一种抗生素替代物可缓解断奶仔猪腹泻并改善肠道健康
Dan Chen,Jiaming Chen,Zemin Dong et al.
Dan Chen et al.
Weaning stress-induced diarrhea is a serious issue in pig production. This study aimed to evaluate the potential of glucose oxidase (GOD) as an antibiotic substitute to alleviate diarrhea and improve gut health in weaned piglets. According ...
Vaccine protection of broilers against various doses of wild-type Salmonella Typhimurium and changes in gut microbiota [0.03%]
针对不同剂量的野毒副猪嗜血杆菌免疫后肉鸡的保护效果及肠道菌群的变化
Samiullah Khan,Andrea R McWhorter,Nicky-Lee Willson et al.
Samiullah Khan et al.
This study evaluated the impact of vaccine diluents (peptone or water) on the protective effects of Salmonella Typhimurium (S. Typhimurium) vaccine. Vaccinated broilers were challenged with different doses of wild-type S. Typhimurium throug...
Multiplexed immunoassay for a serum autoantibody biomarker panel in diagnostic and prognostic prediction of canine mammary tumors [0.03%]
用于犬乳腺肿瘤诊断和预后预测的血清自身抗体生物标志物多重免疫测定法面板研究
Chih-Ching Wu,Chia-Yu Chang,Pei-Yi Chou et al.
Chih-Ching Wu et al.
Canine mammary tumor (CMT) is a prevalent and destructive disease often diagnosed at an advanced stage, leading to poor outcomes. Currently, there is a lack of effective biomarkers for early detection and prognostic prediction of CMT. To im...
Serum concentrations of IL-1β, IL-6, and TNF-α in dogs with chronic kidney disease in uremic syndrome undergoing intermittent hemodialysis with and without bypass [0.03%]
接受间歇性血液透析和旁路血透的尿毒症综合征慢性肾病犬的IL-1β、IL-6和TNF-α血清浓度
Suellen Rodrigues Maia,Maria Gabriela Picelli de Azevedo,Silvano Salgueiro Geraldes et al.
Suellen Rodrigues Maia et al.
Intermittent hemodialysis (IH) is an important therapy in the context of kidney dysfunction in dogs. However, its impact on pro-inflammatory cytokines is unclear. This study assessed IL-1β, IL-6, and TNF-α serum concentrations in dogs wit...
Determination of QLNC-3A6 in canine plasma by UHPLC-MS/MS and its application in pharmacokinetic studies [0.03%]
一种犬血浆中QLNC-3A6的UHPLC-MS/MS测定及其药代动力学研究中的应用
Sumeng Chen,Yu Liu,Yue Wang et al.
Sumeng Chen et al.
Multi-targeted tyrosine kinase inhibitor QLNC-3A6 Di-maleate, a structurally novel small molecule compound, has therapeutic efficacy for the treatment of canine cutaneous mast cell tumor (CMCT) caused by mutations in the c-Kit gene. Since p...
Holstein × Montbéliarde-sired F1 generation crossbred female calves have an increased cellular immune response potential compared with purebred Holsteins [0.03%]
与纯种荷斯坦奶牛相比，荷斯坦×蒙贝利亚F1杂交雌性犊牛具有更佳的细胞免疫应答潜力
Zhipeng Zhang,Chen Yu,Zhi Chen et al.
Zhipeng Zhang et al.
It is well known that crossbreds show many advantages over purebreds in improving calf health traits, but the immunological factors responsible for this heterosis remain largely unclear. The objective of this study was to compare the cellul...