Enhanced tolerance against early and late apoptotic oxidative stress in mammalian neurons through nicotinamidase and sirtuin mediated pathways [0.03%]
烟酸酶和沉默信息调节因子介导的通路通过增强哺乳动物神经元对早期和晚期凋亡氧化应激的耐受性来延长寿命
Zhao Zhong Chong,Kenneth Maiese
Zhao Zhong Chong
Focus upon therapeutic strategies that intersect between pathways that govern cellular metabolism and cellular survival may offer the greatest impact for the treatment of a number of neurodegenerative and metabolic disorders, such as diabet...
Julie Staals,Barbe M A Pieters,Iris L H Knottnerus et al.
Julie Staals et al.
Haptoglobin (Hp) 2-2 phenotype has been associated with peripheral and coronary artery disease and risk of vascular complications in diabetic patients, but any association of Hp polymorphism with cerebrovascular disease has not been explore...
HspB5/alphaB-crystallin: properties and current progress in neuropathy [0.03%]
HspB5/αB晶体蛋白的性质及其在神经病变领域的最新进展
Zhiping Hu,Ting Li
Zhiping Hu
HspB5/alphaB-crystallin (alphaBC), one of the most representative member of mammalian small heat shock protein family (sHsp), shares the common features with other nine members HspB1-B4 and HspB6-10. Meanwhile, it has a strong antiapoptic e...
Kenneth Maiese,Zhao Zhong Chong,Jinling Hou et al.
Kenneth Maiese et al.
Unmitigated oxidative stress can lead to diminished cellular longevity, accelerated aging, and accumulated toxic effects for an organism. Current investigations further suggest the significant disadvantages that can occur with cellular oxid...
MIP-1alpha and MCP-1 Induce Migration of Human Umbilical Cord Blood Cells in Models of Stroke [0.03%]
MIP-1α和MCP-1在卒中模型中诱导人脐带血细胞迁移
Lixian Jiang,Mary Newman,Samuel Saporta et al.
Lixian Jiang et al.
Monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein (MIP-1alpha) are implicated in monocyte infiltration into the central nervous system (CNS) under pathological conditions. We previously showed that in vivo human...
Gelatin-siloxane hybrid scaffolds with vascular endothelial growth factor induces brain tissue regeneration [0.03%]
包含血管内皮生长因子的明胶-硅氧烷杂化支架诱导脑组织再生
Hanzhe Zhang,Tatsushi Kamiya,Takeshi Hayashi et al.
Hanzhe Zhang et al.
In the brain after infarction or trauma, the tissue becomes pannecrotic and forms a cavity. In such situation, a scaffold is necessary to produce new tissue. In this study, we implanted a new porous gelatin-siloxane hybrid derived from gela...
Association of soluble adhesion molecule and C-reactive protein levels with silent brain infarction in patients with and without type 2 diabetes [0.03%]
糖尿病患者和非糖尿病患者的循环细胞黏附分子与 CRP 水平与无症状脑梗死的关系
Toshitaka Umemura,Takahiko Kawamura,Toshimasa Sakakibara et al.
Toshitaka Umemura et al.
Silent brain infarction (SBI) is often detected on MR imaging, however the pathogenesis is still unclear. We aimed to investigate and compare the association of soluble adhesion molecules and C-reactive protein levels with the prevalence of...
Gastrin-releasing peptide receptors regulate proliferation of C6 Glioma cells through a phosphatidylinositol 3-kinase-dependent mechanism [0.03%]
胃泌素释放肽受体通过依赖磷脂酰肌醇-3激酶的作用调控C6glioma细胞的增殖
Debora Gazzana Flores,Caroline Brunetto de Farias,Juliano Leites et al.
Debora Gazzana Flores et al.
Gastrin-releasing peptide (GRP) has been proposed as a major growth factor in brain tumors, and GRP receptor (GRPR) antagonists show antiproliferative effects in experimental gliomas. However, the underlying molecular events downstream of G...
A SELDI-TOF-MS study in Lacunar Stroke with Subsequent Haptoglobin Phenotyping [0.03%]
溶胶-凝胶分散固相萃取飞行时间质谱技术（SELDI-TOF-MS）筛选腔隙性脑梗死患者血浆蛋白峰并进行血红素结合蛋白表型分析的研究
Julie Staals,Judith A P Bons,Robert J van Oostenbrugge et al.
Julie Staals et al.
Using Surface-Enhanced Laser Desorption / Ionization Time-of-Flight Mass Spectrometry (SELDI-TOF-MS), we aimed to detect differences in protein profile in serum samples of two lacunar stroke subtypes. SELDI-TOF-MS, followed by protein ident...
Induction of nuclear receptors and drug resistance in the brain microvascular endothelial cells treated with antiepileptic drugs [0.03%]
抗癫痫药物诱导血脑屏障上皮细胞核受体表达及耐药性研究
Laura Lombardo,Rosalia Pellitteri,Michael Balazy et al.
Laura Lombardo et al.
Our work contributes to the understanding of the mechanisms of drug resistance in epilepsis. This study aimed to investigate i) the levels of expression of P-glycoprotein (P-gp), and multidrug resistance-associated proteins (MRP)1 and 2, ii...