Vascular endothelial growth factor and angiopoietins in neurovascular regeneration and protection following stroke [0.03%]
血管内皮生长因子和血管生成素在卒中后神经血管再生和保护中的作用
Tania M Hansen,Andrew J Moss,Nicholas P J Brindle
Tania M Hansen
Vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang1) were originally identified as endothelial-specific ligands regulating key functions of the vasculature important in stroke. There is increasing evidence that these ligands ...
Gender hormones: role in the pathogenesis of central nervous system disease and demyelination [0.03%]
性别激素：在中枢神经系统疾病和脱髓鞘病发病机制中的作用
Konstantine I Voumvourakis,Sotirios Tsiodras,Dimitrios K Kitsos et al.
Konstantine I Voumvourakis et al.
Gender hormones are associated with the evolution of Multiple Sclerosis (MS) like changes in experimental models of MS. Several clinical studies have attempted to elucidate the role of gender hormones in the evolution of the clinical spectr...
Mild systemic inflammation has a neuroprotective effect after stroke in rats [0.03%]
轻度全身性炎症在卒中后的神经保护作用： rat中的研究
Eugen Bogdan Petcu,Thomas Kocher,Alexander Kuhr et al.
Eugen Bogdan Petcu et al.
Stroke is accompanied by a strong inflammatory reaction in the brain. Periodontal disease is a chronic local infection which causes a systemic low grade inflammation. We hypothesized that a mild systemic inflammatory reaction as caused by p...
Chronic mild stress paradigm reduces sweet food intake in rats without affecting brain derived neurotrophic factor protein levels [0.03%]
慢性轻度压力降低大鼠食甜量而不影响脑源性神经营养因子蛋白水平
Giancarlo Lucca,Clarissa M Comim,Samira S Valvassori et al.
Giancarlo Lucca et al.
Major depression is a common, serious and recurrent disorder that affects 17-20% of the population of the world. The chronic mild stress (CMS) model has been used as an animal model of depression but reflect anhedonia in animals. Present st...
Post traumatic lesion absence of beta-dystroglycan-immunopositivity in brain vessels coincides with the glial reaction and the immunoreactivity of vascular laminin [0.03%]
脑血管β- dystroglycan免疫反应缺失与创伤后的胶质反应和血管层粘连蛋白免疫反应有关
Adrienn Szabó,Mihály Kálmán
Adrienn Szabó
Following brain lesions, the gliovascular basal lamina undergoes destruction and the gliovascular connections 'decouple'. Laminin receptors, as dystroglycan, are essential in these processes. The present study compares the immunoreactivitie...
Neurofibrillary tangles and senile plaques in Alzheimer's brains are associated with reduced capillary expression of vascular endothelial growth factor and endothelial nitric oxide synthase [0.03%]
阿尔茨海默病脑中神经纤维缠结和老年斑与血管内皮生长因子及内皮一氧化氮合酶在毛细血管表达降低相关
John Provias,Brian Jeynes
John Provias
There is significant evidence to suggest that a dysfunctional blood-brain barrier [BBB] may contribute to the pathogenesis of some Alzheimer's disease [AD] lesions. An indicator for this could be diminished capillary vascular endothelial gr...
Hemoglobin neurotoxicity is attenuated by inhibitors of the protein kinase CK2 independent of heme oxygenase activity [0.03%]
蛋白激酶CK2抑制剂可减弱血红蛋白神经营养毒性作用且与其活性无关
Jing Chen-Roetling,Zhi Li,Raymond F Regan
Jing Chen-Roetling
The heme oxygenase (HO) enzymes catalyze the rate-limiting step of heme breakdown, and may accelerate oxidative injury to neurons exposed to heme or hemoglobin. HO-1 and HO-2 are activated in vitro by the phos-phatidylinositol 3-kinase (PI3...
Basolateral aggregated rat amyloidbeta(1-42) potentiates transmigration of primary rat monocytes through a rat blood-brain barrier [0.03%]
基底外侧聚集的淀粉样蛋白β(1-42)增强原代大鼠单核细胞通过血脑屏障迁移的能力
Christian Humpel
Christian Humpel
Monocytes adhere and transmigrate through a blood-brain barrier (BBB) during a normal immune patrol and after pathological events. It is well established that the transmigration of monocytes through the BBB is stimulated by soluble amyloidb...
Transient cerebral ischemia leads to TGF-beta2 expression in Golgi apparatus organelles [0.03%]
短暂性脑缺血导致高尔基器囊泡表达转化生长因子-β2
Zhiping Hu,Jie Fan,Liuwang Zeng et al.
Zhiping Hu et al.
Transforming growth factor2 (TGFbeta2) is a prototypic member of a large superfamily of multifunctional cytokines, and its potential mechanisms of the neuroprotective activity in ischemic stroke and subcellular compartmentalization are larg...
Progressive brain damage and alterations in dendritic arborization after collagenase-induced intracerebral hemorrhage in rats [0.03%]
胶原酶诱导的颅内出血大鼠脑损害的进展及树突变化
Angela P Nguyen,Hang D Huynh,Suzanne B Sjovold et al.
Angela P Nguyen et al.
Intracerebral hemorrhage (ICH) was widely believed to be a monophasic event whereby cell death occurs from the initial space-occupying effects of the hematoma. However, we now know that secondary degenerative events contribute to delayed ce...