Use of telemetry blood pressure transmitters to measure intracranial pressure (ICP) in freely moving rats [0.03%]
利用遥测血压发射器测量自由活动型大鼠脑室内压(ICP)
Gergely Silasi,Crystal L MacLellan,Frederick Colbourne
Gergely Silasi
Stroke and traumatic brain injuries often lead to cerebral edema and persistent elevations in intracranial pressure (ICP) that can be life threatening. Thus, rodent models would benefit from a simple and reliable method to measure ICP in aw...
Fluorogold induces persistent neurological deficits and circling behavior in mice over-expressing human mutant tau [0.03%]
氟金酸诱导tau蛋白突变小鼠产生持久的神经功能缺损和转圈行为
Zhen He
Zhen He
An increasing number of applications use nanospecie-fluorescent labeling technology; however, no established guidelines are available to warrant their safety for potential clinical use. Here, rTg4510 transgenic mice and their littermate con...
Brain-derived neurotrophic factor (BDNF) has proliferative effects on neural stem cells through the truncated TRK-B receptor, MAP kinase, AKT, and STAT-3 signaling pathways [0.03%]
脑源性神经营养因子通过TRKB剪切体、MAP激酶、AKT和STAT-3信号转导途径促进神经干细胞增殖
Omedul Islam,Tze X Loo,Klaus Heese
Omedul Islam
Neurospheres can be generated from the mouse fetal forebrain by exposing multipotent neural stem cells (NSCs) to epidermal growth factor (EGF). In the presence of EGF, NSCs can proliferate continuously while retaining the potential to diffe...
Haptoglobin phenotype may alter endothelial progenitor cell cluster formation in cerebral small vessel disease [0.03%]
血红蛋白表型可能改变脑小血管疾病中的内皮祖细胞簇形成
R P W Rouhl,R J van Oostenbrugge,J G M C Damoiseaux et al.
R P W Rouhl et al.
Cerebral small vessel disease results in silent ischemic lesions (SIL) among which is leukoaraiosis. In this process, endothelial damage is probably involved. Endothelial progenitor cells (EPC), are involved in endothelial repair. By restor...
The forkhead transcription factor FOXO3a controls microglial inflammatory activation and eventual apoptotic injury through caspase 3 [0.03%]
FOXO3a调控叉头转录因子通过半胱天冬酶-3控制小胶质细胞炎性激活及最终的凋亡损伤
Yan Chen Shang,Zhao Zhong Chong,Jinling Hou et al.
Yan Chen Shang et al.
Memory loss and cognitive failure are increasingly being identified as potential risks with the recognized increase in life expectancy of the general population. As a result, the development of novel therapeutic strategies for disorders suc...
RNase therapy assessed by magnetic resonance imaging reduces cerebral edema and infarction size in acute stroke [0.03%]
磁共振成像评估的核糖核酸酶治疗可减少急性卒中的脑水肿和梗死体积
Maureen Walberer,Marlene Tschernatsch,Silvia Fischer et al.
Maureen Walberer et al.
Ischemic stroke causes cell necrosis with the exposure of extracellular ribonucleic acid (RNA) and other intracellular material. As shown recently, extracellular RNA impaired the blood-brain-barrier and contributed to vasogenic edema-format...
Secondary brain injuries in thalamus and hippocampus after focal ischemia caused by mild, transient extradural compression of the somatosensori cortex in the rat [0.03%]
短暂性体外包膜挤压感觉皮层引起的局灶性脑缺血后丘脑和海马的继发性脑损伤
Per Holmberg,Sture Liljequist,Anna Wägner
Per Holmberg
The development and distribution of secondary brain lesions, subsequent to ischemic stroke, are of considerable clinical interest but so far only a limited number of studies have investigated the distribution and development of these second...
Sukhes Mukherjee,Subir Kumar Das,Kannan Vaidyanathan et al.
Sukhes Mukherjee et al.
Alcohol one of the important products of the global addiction alters brain function by interacting with multiple neurotransmitter systems, thereby disrupting the delicate balance between inhibitory and excitatory neurotransmitters. Alcohol ...
Erica Menegatti,Paolo Zamboni
Erica Menegatti
Physiologic functioning of the cerebrovenous system is indispensable for maintaining normal brain function. However, in contrast to the cerebroarterial system, the cerebral venous return is not routinely investigated. Combined high-resoluti...
Vascular endothelial growth factor in central nervous system injuries - a vascular growth factor getting nervous? [0.03%]
血管内皮生长因子与中枢神经系统损伤——一个血管生成因子正在变得神经兮兮？
Mattias K Sköld,Martin Kanje
Mattias K Sköld
Vascular Endothelial Growth Factor (VEGF) is recognized as a central factor in growth, survival and permeability of blood vessels in both physiological and pathological conditions. It is as such of importance for vascular responses in vario...