Venous collateral circulation of the extracranial cerebrospinal outflow routes [0.03%]
颅外脑脊液外流途径的静脉旁路循环
Paolo Zamboni,Giuseppe Consorti,Roberto Galeotti et al.
Paolo Zamboni et al.
A new nosologic vascular pattern that is defined by chronic cerebrospinal venous insufficiency (CCSVI) has been strongly associated with multiple sclerosis. The picture is characterized by significant obstacles of the main extracranial cere...
Blood brain barrier compromise with endothelial inflammation may lead to autoimmune loss of myelin during multiple sclerosis [0.03%]
血脑屏障受损与内皮炎症可能在多发性硬化症中导致自身免疫性髓鞘丢失
Marian Simka
Marian Simka
Multiple sclerosis is an autoimmune disease characterized by multifocal areas of inflammation and demyelination within the central nervous system. The mechanism that triggers the disease remains elusive. However, recent findings may indicat...
Neutralizing endogenous VEGF following traumatic spinal cord injury modulates microvascular plasticity but not tissue sparing or functional recovery [0.03%]
脊髓损伤后内源性VEGF的中和不影响组织保存或功能恢复但调节微血管可塑性
Richard L Benton,Melissa A Maddie,Mark J Gruenthal et al.
Richard L Benton et al.
Acute loss of spinal cord vascularity followed by an endogenous adaptive angiogenic response with concomitant microvascular dysfunction is a hallmark of traumatic spinal cord injury (SCI). Recently, the potent vasoactive factor vascular end...
Angelica injection improves functional recovery and motoneuron maintenance with increased expression of brain derived neurotrophic factor and nerve growth factor [0.03%]
当归注射液促进功能恢复和运动神经元维持的作用及其对脑源性神经营养因子和神经生长因子表达的影响
Qin Cui,Junjian Zhang,Lei Zhang et al.
Qin Cui et al.
This study assessed the neuroprotective effects of angelica injection in the rat sciatic nerve crush injury (SCI). Forty eight male Sprague Dawley rats were randomly divided into 4 groups: one was the sham group (S), which received sham sur...
Perinatal asphyxia in preterm neonates leads to serum changes in protein S-100 and neuron specific enolase [0.03%]
早产新生儿围生期窒息可导致S-100蛋白和神经元特异性烯醇化酶的血清变化
Distefano Giuseppe,Curreri Sergio,Betta Pasqua et al.
Distefano Giuseppe et al.
In preterm infants, neurological signs and clinical manifestations of brain damage are limited criteria for diagnosis of neurologic sequelae. Early indicators of brain damage are needed and currently some specific biochemical markers of bra...
Presynaptic NR2B-containing NMDA autoreceptors mediate gluta-matergic synaptic transmission in the rat visual cortex [0.03%]
大鼠视觉皮层中NMDA自受体中的NR2B亚基介导谷氨酸能突触传递
Yan-Hai Li,Jue Wang,Guangjun Zhang
Yan-Hai Li
N-methyl-D-aspartate (NMDA) receptors (NMDA-Rs) have different modulatory effects on excitatory synaptic transmission depending on the receptor subtypes involved. The present study investigated the subunit composition of the presynaptic NMD...
Neutralization of interleukin-1beta reduces vasospasm and alters cerebral blood vessel density following experimental subarachnoid hemorrhage in rats [0.03%]
中性化IL-1β减少实验性蛛网膜下腔出血后血管痉挛并改变脑血管密度
Halina Jedrzejowska-Szypułka,Magdalena Larysz-Brysz,Michał Kukla et al.
Halina Jedrzejowska-Szypułka et al.
Subarachnoid hemorrhage (SAH) develops when extravasated arterial blood enters subarachnoid space and mixes with cerebrospinal fluid. As a result, many pathologies develop, including arterial vasospasm that leads to the ischemia and hypoxia...
Bradykinin is involved in the mediation of cardiac nociception during ischemia through upper thoracic spinal neurons [0.03%]
缓激肽通过上胸段脊髓神经元参与缺血性心绞痛的中介作用
Chao Qin,Jian-qing Du,Jing-shi Tang et al.
Chao Qin et al.
Bradykinin is one of metabolites produced during myocardial ischemia and infarction that can activate cardiac spinal (sympathetic) sensory neurons to cause chest pain. The aim of this study was 1) to characterize the responses of thoracic s...
Depressed glucose consumption at reperfusion following brain ischemia does not correlate with mitochondrial dysfunction and development of infarction: an in vivo positron emission tomography study [0.03%]
脑缺血再灌注时葡萄糖消耗降低与线粒体功能障碍和梗死的发展无关：一项体内正电子发射断层扫描研究
Abraham Martín,Santiago Rojas,Deborah Pareto et al.
Abraham Martín et al.
Glucose consumption is severely depressed in the ischemic core, whereas it is maintained or even increased in penumbral regions during ischemia. Conversely, glucose utilization is severely reduced early after reperfusion in spite that gluco...
Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection [0.03%]
白藜芦醇与神经退行性疾病：激活SIRT1通路的神经保护作用研究
Mercè Pallàs,Gemma Casadesús,Mark A Smith et al.
Mercè Pallàs et al.
One of the current problems in medicine research is the development of safe drugs for the treatment of neurological disorders. Furthermore, there is a close relationship between the process of aging and the appearance of neurological disord...