Chronic methylphenidate-effects over circadian cycle of young and adult rats submitted to open-field and object recognition tests [0.03%]
青春期前后持续摄取注意缺陷多动障碍药物对昼夜节律的影响——基于开放式场地实验和物体识别实验的结果
Karin M Gomes,Renan P Souza,Samira S Valvassori et al.
Karin M Gomes et al.
In this study age-, circadian rhythm- and methylphenidate administration- effect on open field habituation and object recognition were analyzed. Young and adult male Wistar rats were treated with saline or methylphenidate 2.0 mg/kg for 28 d...
Preservation of cellular glutathione status and mitochondrial membrane potential by N-acetylcysteine and insulin sensitizers prevent carbonyl stress-induced human brain endothelial cell apoptosis [0.03%]
N-乙酰半胱氨酸和胰岛素增敏剂通过保持细胞型谷胱甘肽状态和线粒体膜电位来预防羰基应激诱导的人脑内皮细胞凋亡
Masahiro Okouchi,Naotsuka Okayama,Tak Yee Aw
Masahiro Okouchi
Oxidative stress-induced cerebral endothelial cell dysfunction is associated with cerebral microvascular complication of primary diabetic encephaolopathy, a neurodegenerative disorder of long-standing diabetes, but the injury mechanisms are...
Cortical and putamen age-related changes in the microvessel density and astrocyte deficiency in spontaneously hypertensive and stroke-prone spontaneously hypertensive rats [0.03%]
自发性高血压和易卒中型自发性高血压大鼠脑皮质及纹状体微血管密度与星形胶质细胞的变化
Marie-Françoise Ritz,Felix Fluri,Stefan T Engelter et al.
Marie-Françoise Ritz et al.
Cerebral small vessel disease (SVD) is a major contributor to dementia in the elderly, and hypertension represents a major cause for developing the disease. However, little is known about its development and progression. Modifications of la...
CB-12181, a new azasugar-based matrix metalloproteinase/tumor necrosis factor-alpha converting enzyme inhibitor, inhibits vascular endothelial growth factor-induced angiogenesis in vitro and retinal neovascularization in vivo [0.03%]
新型氨基糖类金属基质金属蛋白酶/肿瘤坏死因子-α转化酶抑制剂CB-12181对血管内皮生长因子诱导的体内外血管生成的作用
Yuichi Chikaraishi,Masamitsu Shimazawa,Koichi Yokota et al.
Yuichi Chikaraishi et al.
To evaluate the anti-angiogenic efficacy of CB-12181 [an azasugar derivative that has inhibitory actions against matrix metalloproteinases (MMPs) and tumor necrosis factor-alpha (TNF-alpha) converting enzyme (TACE)], we investigated the sup...
Near Infrared Spectroscopy in healthy preterm and term newborns: correlation with gestational age and standard monitoring parameters [0.03%]
近红外光谱在健康早产儿及足月新生儿中的应用：与胎龄及其他常规监测参数的相关性研究
Lucia Gabriella Tina,Alessandro Frigiola,Raul Abella et al.
Lucia Gabriella Tina et al.
Near Infrared Spectroscopy (NIRS) is an emerging technique for brain oxygenation monitoring in newborns complicated by acute and chronic hypoxia. However, data regarding cerebral oxygenation normal values are still lacking and matter of deb...
Blood pressure and white matter lesions in patients with vascular disease: the SMART-MR study [0.03%]
血管疾病患者的血压和白质病变：SMART-MR研究
A L M Vlek,F L J Visseren,L J Kappelle et al.
A L M Vlek et al.
White matter lesions (WML) are a frequent finding on brain magnetic resonance imaging scans. Elevated blood pressure (BP) is consistently identified as risk factor for WML. However, it is unknown whether BP still is associated with WML in p...
Disease outcome, alexithymia and depression are differently associated with serum IL-18 levels in acute stroke [0.03%]
急性脑卒中患者疾病预后、病前 alexithymia 和抑郁与血清 IL-18 水平的关系研究
Paola Bossù,Francesca Salani,Claudia Cacciari et al.
Paola Bossù et al.
Stroke has been shown to lead to depressive disorders, anxiety disorders and other emotional consequences. Although the cause of these disorders is a subject of debate, stroke has clearly been shown to lead to the production of pro-inflamma...
The pro-apoptotic substance thapsigargin selectively stimulates re-growth of brain capillaries [0.03%]
凋亡诱导物质thapsigargin可选择性地刺激脑毛细血管再生生长
Celine Ullrich,Christian Humpel
Celine Ullrich
Thapsigargin is a pro-apoptotic chemical, which has been shown to be useful to study cell death of cholinergic or dopaminergic neurons, or cells, which degenerate in Alzheimer's disease or Parkinson's disease, respectively. The aim of the p...
Peroxisome-proliferator-activated receptor-alpha activation protects brain capillary endothelial cells from oxygen-glucose deprivation-induced hyperpermeability in the blood-brain barrier [0.03%]
过氧化物酶体增殖激活受体α活化保护血脑屏障脑血管内皮细胞免于氧糖剥夺引起的高通透性现象
Caroline Mysiorek,Maxime Culot,Lucie Dehouck et al.
Caroline Mysiorek et al.
That promising neuroprotectants failed to demonstrate benefit against stroke highlights the great difficulties to translate preclinical pharmacological effects in clinical outcomes. Part of this hurdle implies the complex response to injury...
Clarissa M Comim,Leandra C Constantino,Tatiana Barichello et al.
Clarissa M Comim et al.
Sepsis is a major disease entity with important clinical implications. It is associated with a high mortality rate in humans. Recently, several studies have demonstrated that Intensive Care Unit survivors present long-term cognitive impairm...