Nitric oxide production during cerebral ischemia and reperfusion in eNOS- and nNOS-knockout mice [0.03%]
在eNOS和nNOS基因敲除小鼠脑缺血再灌注时的硝酸氧化物产生情况
Yasuo Ito,Takeshi Ohkubo,Yoshio Asano et al.
Yasuo Ito et al.
The purpose of this study was to clarify the kinetics of nitric oxide (NO) induced by either endothelial NO synthase (eNOS) or neuronal NO synthase (nNOS) after transient global forebrain ischemia. We investigated NO production and ischemic...
Real time analysis of neurotransmitters in the brain using a micro-electrode system [0.03%]
基于微电极系统在脑内神经递质的实时分析研究
Suw Young Ly,Hwa Jin Heo,Min Jung Kim
Suw Young Ly
Neurotransmitters catechol and dopamine analogy levels are related to the systematic nerve activity. This assay was performed using cyclic voltammetry (CV) and square wave (SW) stripping voltammetry, while optimization was performed by the ...
Interleukin-1beta plays a role in the activation of peripheral leukocytes after blood-brain barrier rupture in the course of subarachnoid hemorrhage [0.03%]
颅内动脉瘤破裂后脑屏障损伤、白细胞激活及细胞炎症因子的作用机制研究Intermediate II和Wide-Necked动脉瘤血管内治疗的单中心经验分享
Halina Jedrzejowska-Szypułka,Grazyna Straszak,Magdalena Larysz-Brysz et al.
Halina Jedrzejowska-Szypułka et al.
Subarachnoid hemorrhage (SAH) develops when extravasated arterial blood enters subarachnoid space and mixes with cerebrospinal fluid. As a result, many pathologies develop, including increase in brain-blood barrier (BBB) permeability and ac...
Human tooth germ stem cells preserve neuro-protective effects after long-term cryo-preservation [0.03%]
人牙胚干细胞长期冻存后仍具有神经保护作用
Mehmet E Yalvaç,Mustafa Ramazanoglu,Murat Tekguc et al.
Mehmet E Yalvaç et al.
The use of mesenchymal stem cells (MSCs) has been shown to be promising in chronic disorders such as diabetes, Alzheimer's dementia, Parkinson's disease, spinal cord injury and brain ischemia. Recent studies revealed that human tooth germs ...
Kenneth Maiese,Yan Chen Shang,Zhao Zhong Chong et al.
Kenneth Maiese et al.
Diabetes mellitus (DM) impacts a significant portion of the world's population and care for this disorder places an economic burden on the gross domestic product for any particular country. Furthermore, both Type 1 and Type 2 DM are becomin...
Oxidative stress-induced necrotic cell death via mitochondira-dependent burst of reactive oxygen species [0.03%]
活性氧介导的氧化压力诱导的坏死型细胞死亡
Kyungsun Choi,Jinho Kim,Gyung W Kim et al.
Kyungsun Choi et al.
Oxidative stress is deeply involved in various brain diseases, including neurodegenerative diseases, stroke, and ischemia/reperfusion injury. Mitochondria are thought to be the target and source of oxidative stress. We investigated the role...
FoxO3a governs early microglial proliferation and employs mitochondrial depolarization with caspase 3, 8, and 9 cleavage during oxidant induced apoptosis [0.03%]
FoxO3a调控早期小胶质细胞增殖并诱导氧化剂诱导的凋亡中线粒体去极化及caspase 3、8和9的剪切作用
Yan Chen Shang,Zhao Zhong Chong,Jinling Hou et al.
Yan Chen Shang et al.
Microglia of the central nervous system have a dual role in the ability to influence the survival of neighboring cells. During inflammatory cell activation, microglia can lead to the disposal of toxic cellular products and permit tissue reg...
Spatial correlations between the vacuolation, prion protein (PrPsc) deposits and the cerebral blood vessels in sporadic Creutzfeldt-Jakob disease [0.03%]
sporadic克雅氏病中空泡形成、prion蛋白（PrPsc）沉积和脑血管之间的空间相关性
Richard A Armstrong
Richard A Armstrong
In the variant form of Creutzfeldt-Jakob disease (vCJD), 'florid' deposits of the protease resistant form of prion protein (PrP(sc)) were aggregated around the cerebral blood vessels suggesting the possibility that prions may spread into th...
Role of endogenous granulocyte-macrophage colony stimulating factor following stroke and relationship to neurological outcome [0.03%]
缺血性脑卒中后内源性粒细胞-巨噬细胞集落刺激因子的作用及与神经功能转归的关系研究
Miriam Navarro-Sobrino,Anna Rosell,Anna Penalba et al.
Miriam Navarro-Sobrino et al.
Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) is a proinflammatory cytokine with neuroprotective and angiogenic properties demonstrated in animal models of cerebral ischemia but their role in human ischemic stroke is still unkno...
The immunosuppressive agent FK506 prevents subperineurial degeneration and demyelination on ultrastructural and functional analysis [0.03%]
免疫抑制剂FK506可防止亚外髓鞘变性和脱髓鞘(超微结构和功能分析)
Arzu Utuk,Levent Sarikcioglu,Bahadir M Demirel et al.
Arzu Utuk et al.
Several kinds of injury models, such as crush, transection and graft repair have been well studied in terms of neuroprotective effect of FK506. However, definitive experimental studies are lacking on focal degeneration or ischemia. In the p...