Leptin reduces infarct size in association with enhanced expression of CB2, TRPV1, SIRT-1 and leptin receptor [0.03%]
瘦素通过促进CB2、TRPV1、SIRT-1和瘦素受体表达增强而减少梗死面积
Yosefa Avraham,Neta Davidi,Moran Porat et al.
Yosefa Avraham et al.
Brain ischemia is associated with detrimental changes in energy production and utilization. Therefore, we hypothesized that leptin, an adipokynin hormone protecting against severe energy depletion, would reduce infarct volume and improve fu...
Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation [0.03%]
Sirt1通过核转运、Forkhead转位、Bad和线粒体半胱天冬酶活化决定早期血管细胞凋亡信号
Jinling Hou,Zhao Zhong Chong,Yan Chen Shang et al.
Jinling Hou et al.
Complications of diabetes mellitus (DM) weigh heavily upon the endothelium that ultimately affect multiple organ systems. These concerns call for innovative treatment strategies that employ molecular pathways responsible for cell survival a...
Ginsenoside Rbeta1 reduces neurologic damage, is anti-apoptotic, and down-regulates p53 and BAX in subarachnoid hemorrhage [0.03%]
Ginsenoside Rβ1减少神经损伤，具有抗细胞凋亡作用并抑制p53和BAX蛋白在蛛网膜下腔出血患者中的表达
Yingbo Li,Jiping Tang,Nikan H Khatibi et al.
Yingbo Li et al.
Stroke is the second leading cause of death worldwide and the number one cause of adult disability in the United States and Europe. A subtype of stroke, subarachnoid hemorrhage (SAH), accounts for 7% of all strokes each year and claims one ...
Liuwang Zeng,Zhiping Hu,Wei Lu et al.
Liuwang Zeng et al.
Small heat shock proteins(sHSPs), with a small molecular mass of 12-43 kDa, are molecular chaperones that protect cells against stress by assisting them in the correct folding of denatured proteins and thus prevent aggregation of misfolded ...
Sublethal total body irradiation leads to early cerebellar damage and oxidative stress [0.03%]
亚致死全身照射导致早期小脑损伤和氧化应激反应
Li Cui,Dwight Pierce,Kim E Light et al.
Li Cui et al.
The present study aimed at identifying early damage index in the cerebellum following total body irradiation (TBI). Adult male CD2F1 mice (n=18) with or without TBI challenge (8.5 Gy irradiation) were assessed for histology and expression o...
Experimental diabetes mellitus down-regulates large-conductance Ca2+-activated K+ channels in cerebral artery smooth muscle and alters functional conductance [0.03%]
实验性糖尿病下调脑动脉平滑肌大电导钙激活钾通道并改变功能电导
Yan Wang,Hong-Tao Zhang,Xing-Li Su et al.
Yan Wang et al.
Cerebral vascular dysfunction and associated vascular complications often develop over time in type-2 diabetes, but the underlying mechanisms are not wholly understood. The aim of the present study was to investigate whether large-conductan...
Ryota Ishibashi,Tomohiro Aoki,Masaki Nishimura et al.
Ryota Ishibashi et al.
Cerebral aneurysm (CA) has a high prevalence and causes a fatal subarachnoid hemorrhage. Although CA is a socially important disease, there are currently no medical treatments for CA, except for surgical procedures, because the detailed mec...
Haptoglobin phenotype correlates with the extent of cerebral deep white matter lesions in hypertensive patients [0.03%]
血型表型与高血压患者脑深部白质病变范围的相关性研究
Julie Staals,Léon H G Henskens,Joris R Delanghe et al.
Julie Staals et al.
Cerebral white matter lesions (WMLs), due to small vessel disease, can be regarded as an early "silent" sign of hypertensive cerebral end-organ damage. As haptoglobin (Hp) phenotype has earlier been associated with symptomatic vascular dise...
Characterization of endogenous neural progenitor cells after experimental ischemic stroke [0.03%]
实验性缺血性卒中后内源性神经干细胞的特征分析
Chiung-Chyi Shen,Yi-Chin Yang,Ming-Tsang Chiao et al.
Chiung-Chyi Shen et al.
Neural progenitors cells are capable of promoting neurogenesis after ischemic stroke in the adult mammalian brain; however the function of these cells and their fate is still not clear. Therefore the purpose of this study investigated the r...
Iron leads to memory impairment that is associated with a decrease in acetylcholinesterase pathways [0.03%]
铁导致与乙酰胆碱酯酶通路减少相关的记忆障碍
Vinícius Pieta Perez,Maria Noêmia Martins de Lima,Rosane Souza da Silva et al.
Vinícius Pieta Perez et al.
Increasing evidence indicates that excessive iron in selective regions of the brain may be involved in the etiology of neurodegenerative disorders. Accordingly, increased levels of iron have been described in brain regions of patients in Pa...