Hypoxia-inducible factor-1α contributes to brain edema after stroke by regulating aquaporins and glycerol distribution in brain [0.03%]
缺氧诱导因子-1α通过调节脑内水通道蛋白及甘油分布参与脑卒中后脑水肿形成
Tetsuhiro Higashida,Changya Peng,Jie Li et al.
Tetsuhiro Higashida et al.
Brain edema following stroke is a critical clinical problem due to its association with increased morbidity and mortality. Despite its significance, present treatment for brain edema simply provides symptomatic relief due to the fact that m...
Pei-Lin Chen,Alexander S Easton
Pei-Lin Chen
Angiogenesis is implicated in diseases of the central nervous system, and its modulation represents an attractive therapeutic strategy. This is the first report of the effects of resveratrol (trans-3,4',5-trihydroxystilbene) on cerebral ang...
Protein-energy malnutrition alters hippocampal plasticity-associated protein expression following global ischemia in the gerbil [0.03%]
蛋白质-能量营养不良影响全球缺血引起的海马塑料相关蛋白表达
Erin J Prosser-Loose,Valerie M K Verge,Francisco S Cayabyab et al.
Erin J Prosser-Loose et al.
Previously it has been demonstrated that protein-energy malnutrition (PEM) impairs habituation in the open field test following global ischemia. The present study examined the hypothesis that PEM exerts some of its deleterious effects on fu...
Traumatic spinal cord injury alters angiogenic factors and TGF-beta1 that may affect vascular recovery [0.03%]
创伤性脊髓损伤改变了血管生成因子和TGF-β1可能影响血管恢复
Marie-Françoise Ritz,Ursula Graumann,Bertha Gutierrez et al.
Marie-Françoise Ritz et al.
Traumatic spinal cord injury (SCI) disrupts the blood-spinal cord barrier and reduces the blood supply caused by microvascular changes. Vessel regression and neovascularization have been observed in the course of secondary injury contributi...
Hsp20 protects neuroblastoma cells from ischemia/reperfusion injury by inhibition of apoptosis via a mechanism that involves the mitochondrial pathways [0.03%]
热休克蛋白27通过抑制线粒体凋亡途径保护神经母细胞瘤细胞缺血再灌注损伤
Liuwang Zeng,Jieqiong Tan,Zhiping Hu et al.
Liuwang Zeng et al.
Hsp20 is chaperone protein that is highly and constitutively expressed in the brain, cardiac tissue and many other organs. Recently, it is well established that Hsp20 can enhance cardiac function and render cardioprotection. However, the po...
Environmental enrichment influences BDNF and NR1 levels in the hippocampus and restores cognitive impairment in chronic cerebral hypoperfused rats [0.03%]
环境丰富通过上调海马BDNF和NR1水平改善慢性脑低灌注大鼠认知障碍
Huimin Sun,Junjian Zhang,Lei Zhang et al.
Huimin Sun et al.
An enriched environment (EE) is beneficial in modifying behaviors, particularly in tasks involving complex cognitive functions. However, the impact of EE on cognitive impairment induced by chronic cerebral hypoperfusion (CCH) has not been s...
M V Catani,V Gasperi,G Catanzaro et al.
M V Catani et al.
In the last decade, the neurovascular effects exerted by endocannabinoids (eCBs) have attracted growing interest, because they hold the promise to open new avenues of therapeutic intervention against major causes of death in Western society...
Chronic hypoxia potentiates age-related oxidative imbalance in brain vessels and synaptosomes [0.03%]
慢性缺氧加剧脑血管和突触体的年龄相关氧化不平衡
Cristina Carvalho,Maria S Santos,Inês Baldeiras et al.
Cristina Carvalho et al.
This study was aimed to evaluate and compare the effect of chronic hypoxia and aging in the oxidative status of brain vessels and synaptosomes. For this purpose we isolated brain vessels and synaptosomes from 3- and 12-month-old rats subjec...
Interleukin-1 drives cerebrovascular inflammation via MAP kinase-independent pathways [0.03%]
白细胞介素-1通过MAP激酶非依赖通路驱动脑血管炎症反应
Peter Thornton,Barry W McColl,Laura Cooper et al.
Peter Thornton et al.
Cerebrovascular inflammation is triggered by diverse central nervous system (CNS) insults and contributes to disease pathogenesis. The pro-inflammatory cytokine interleukin (IL)-1 is central to this cerebrovascular inflammatory response and...
Free radical scavenger edaravone administration protects against tissue plasminogen activator induced oxidative stress and blood brain barrier damage [0.03%]
依达拉奉对抗组织型纤溶酶原激活物诱导的氧化应激和血脑屏障损害
Violeta Lukic-Panin,Kentaro Deguchi,Toru Yamashita et al.
Violeta Lukic-Panin et al.
One of the therapeutics for acute cerebral ischemia is tissue plasminogen activator (t-PA). Using t-PA after 3 hour time window increases the chances of hemorrhage, involving multiple mechanisms. In order to show possible mechanisms of t-PA...