Erythropoietin and Wnt1 govern pathways of mTOR, Apaf-1, and XIAP in inflammatory microglia [0.03%]
促红细胞生成素和Wnt1在炎症小胶质细胞中调节mTOR、Apaf-1和XIAP通路
Yan Chen Shang,Zhao Zhong Chong,Shaohui Wang et al.
Yan Chen Shang et al.
Inflammatory microglia modulate a host of cellular processes in the central nervous system that include neuronal survival, metabolic fluxes, foreign body exclusion, and cellular regeneration. Elucidation of the pathways that oversee microgl...
Leptin induces neuroprotection neurogenesis and angiogenesis after stroke [0.03%]
瘦素在卒中后神经保护、神经发生和血管生成中的作用
Y Avraham,N Davidi,V Lassri et al.
Y Avraham et al.
Leptin is a potent AMP kinase (AMPK) inhibitor that is central to cell survival. Hence, we explored the effects of leptin on neurogenesis and angiogenesis after stroke. Neural stem cells (NSC) were grown as neurospheres in culture and treat...
Exposure to enriched environment restores the mRNA expression of mineralocorticoid and glucocorticoid receptors in the hippocampus and ameliorates depressive-like symptoms in chronically stressed rats [0.03%]
富足环境暴露可改善慢性应激大鼠抑郁样行为并恢复海马区盐皮质激素受体和糖皮质激素受体的mRNA表达水平
Lei Zhang,Junjian Zhang,Huimin Sun et al.
Lei Zhang et al.
Chronic stress can cause emotional dysfunction, but exposure to an enriched environment (EE) can benefit emotional homeostasis. Recent studies have demonstrated that EE can ameliorate stress-induced depressive-like behaviors. Whether hypoth...
Modelling the neurovascular unit and the blood-brain barrier with the unique function of pericytes [0.03%]
具有周细胞独特功能的神经血管单元和血脑屏障的建模研究
Elodie Vandenhaute,Lucie Dehouck,Marie-Christine Boucau et al.
Elodie Vandenhaute et al.
The blood-brain barrier (BBB) is a dynamic cellular complex that is responsible for the maintenance of brain homeostasis. To understand the BBB's key cellular and molecular mechanisms, in vitro models combining endothelial cells and astrocy...
Nrf2 and NF-κB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes [0.03%]
诱导型特异性 NRF2 和NF-κB 激活剂苏黄酮对抗糖尿病大鼠和高糖诱导的雪旺细胞神经病变化的作用机制研究
Geeta Negi,Ashutosh Kumar,Shyam S Sharma
Geeta Negi
High glucose driven reactive oxygen intermediates production and inflammatory damage are recognized contributors of nerve dysfunction and subsequent damage in diabetic neuropathy. Sulforaphane, a known chemotherapeutic agent holds a promise...
Combination treatment with rt-PA is more effective than rt-PA alone in an in vitro human clot model [0.03%]
在人体血栓模型中，与单独使用rt-PA相比，联合治疗更有效
Jason M Meunier,Christy K Holland,Tyrone M Porter et al.
Jason M Meunier et al.
Incidence of intra-cranial hemorrhage linked to treatment of ischemic stroke with recombinant tissue plasminogen activator (rt-PA) has led to interest in adjuvant therapies such as ultrasound (US) or plasminogen, to enhance rt-PA efficacy a...
Xiaomei Guan,Chao Tu,Mengjun Li et al.
Xiaomei Guan et al.
HSP22 (heat shock protein 22), belonging to the superfamily of small heat shock proteins, which has a molecular mass of 21.6 KD and is able to exist in the form of monomer, has multiple functions including molecular chaperones, apoptosis an...
Necessity for re-vascularization after spinal cord injury and the search for potential therapeutic options [0.03%]
脊髓损伤后的血管重建必要性及其潜在治疗手段的研究
Ursula Graumann,Marie-Françoise Ritz,Oliver Hausmann
Ursula Graumann
Disruption of the blood-spinal cord barrier (BSCB) and microvascular changes leading to reduction of blood supply represent hallmarks of spinal cord secondary injury causing further deterioration of the traumatized patient. Injury to the bl...
Dopamine and vascular dynamics control: present status and future perspectives [0.03%]
多巴胺与血管动力学控制：现状及未来展望
Seyed Khosrow Tayebati,Mustafa F Lokhandwala,Francesco Amenta
Seyed Khosrow Tayebati
The catecholamine dopamine is a precursors in the biosynthesis of norepinephrine and epinephrine as well as a neurotransmitter in the central nervous system. Besides of its well known role of brain neurotransmitter, dopamine exerts specific...
Ameliorative effects of GW1929, a nonthiazolidinedione PPARγ agonist, on inflammation and apoptosis in focal cerebral ischemic-reperfusion injury [0.03%]
GW1929（一种非噻唑烷二酮PPARγ激动剂）改善焦点脑缺血-再灌注损伤炎症和凋亡的作用
Ravinder K Kaundal,Shyam S Sharma
Ravinder K Kaundal
PPARγ agonist; 2-(Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino) ethyl]-L-tyrosine (GW1929) in focal cerebral ischemic-reperfusion (IR) injury in rats. Focal cerebral IR injury resulted significant brain infarction and neurological deficits...