Platelet-derived secreted amyloid-precursor protein-β as a marker for diagnosing Alzheimer's disease [0.03%]
血小板源性分泌型早老素前体蛋白-β作为阿尔茨海默病诊断标志物的潜力
Josef Marksteiner,Christian Humpel
Josef Marksteiner
A marker of Alzheimer's disease (AD) with a high sensitivity and specificity would facilitate a diagnosis at early stages. Blood platelets may be of particular interest in search of biomarkers, because they express amyloid-precursor protein...
Hector Rosas-Hernandez,Elvis Cuevas,Susan M Lantz et al.
Hector Rosas-Hernandez et al.
The blood-brain barrier (BBB) consists in part of a highly specialized set of cells which separates the brain from the vascular system. The BBB controls the entry and exit of substances from the brain tissue through tight junctions (TJs) be...
Transient blood brain barrier disruption induced by oleic acid is mediated by nitric oxide [0.03%]
油酸所致血脑屏障的暂时性损害由一氧化氮介导
Hyung Soo Han,Jae Hee Jang,Jae Sik Park et al.
Hyung Soo Han et al.
The blood brain barrier (BBB) maintains cerebral microenvironmental homeostasis. Transient disruption of the BBB after brain fat embolism in clinical cases and animal models has been reported but the precise mechanism underlying this occurr...
Vehicles for lipophilic drugs: implications for experimental design, neuroprotection, and drug discovery [0.03%]
脂ophilic药物的给药方式：对实验设计、神经保护和药物发现的影响
Jack Rivers-Auty,John C Ashton
Jack Rivers-Auty
The delivery of some classes of drugs is challenging. Solubility, absorption, distribution, and duration of action may all be altered by combination with vehicle molecules. It has already been discovered that polyethylene glycol - which is ...
Radix Angelica Sinensis that contains the component Z-ligustilide promotes adult neurogenesis to mediate recovery from cognitive impairment [0.03%]
当归含Z-ligustilide促进成年神经发生介导认知障碍恢复作用研究
Jiawei Xin,Junjian Zhang,Ying Yang et al.
Jiawei Xin et al.
Radix Angelica Sinensis (RAS) has beneficial effects in patients suffering from cognitive impairment associated with chronic cerebral hypoperfusion. It has previously been demonstrated that RAS prevents the neurotoxic effects of β-amyloid ...
Jin-Gang Yu,Lin-Yan Yu,Xin-Yu Jiang et al.
Jin-Gang Yu et al.
As an incomplete renal replacement for the patients with either acute or chronic renal failure, membrane-based hemodialysis therapy is progressing rapidly. However, the mortality and morbidity remain unacceptably high. Much effort has been ...
Implementation of a biocircuit implants for neurotransmitter release during neuro-stimulation [0.03%]
一种用于神经刺激期间释放神经递质的生物电路植入设备的实现方法
Suw Young Ly,Dal woong Choi
Suw Young Ly
Neurotransmitter assay of epinephrine (EP) was sought using a modified carbon nanotube paste electrode (PE). Using optimum conditions, cyclic voltammetry (CV) and the square wave (SW) stripping voltammetric working ranges were attained to 1...
Reacting to stress: radical cellular pathways for novel drug development [0.03%]
应对压力：细胞的非常规途径在新药开发中的应用
Kenneth Maiese
Kenneth Maiese
Boguslaw Lipinski,Etheresia Pretorius
Boguslaw Lipinski
Accumulating evidence within the last two decades indicates the association between cardiovascular disease (CVD) and chronic inflammatory state. Under normal conditions fibrin clots are gradually degraded by the fibrinolytic enzyme system, ...
Beatriz Gómez-González,Gabriela Hurtado-Alvarado,Enrique Esqueda-León et al.
Beatriz Gómez-González et al.
The functions of rapid eye movement (REM) sleep have remained elusive since more than 50 years. Previous reports have identified several independent processes affected by the loss and subsequent recovery of REM sleep (hippocampal neurogenes...