Transplantation of undifferentiated bone-marrow stromal cells into a vein graft accelerates sciatic nerve regeneration in streptozotocin induced diabetic rats [0.03%]
骨髓stromal细胞静脉移植加速链脲佐菌素诱导的糖尿病大鼠坐骨神经再生
Amin Haghighat,Rahim Mohammadi,Keyvan Amini
Amin Haghighat
Influence of undifferentiated bone marrow stromal cells (BMSCs) combined with vein graft on transected sciatic nerve repair was studied in diabetic rats. A nerve segment, 10 mm, was excised and a vein graft (VG) was used to bridge the gap. ...
Pradeep Hanumanthappa,Asha Densi,Rajanikant Golgodu Krishnamurthy
Pradeep Hanumanthappa
Glycogen synthase kinase 3β (GSK-3β) is implicated in diverse cellular processes such as cell signaling and survival. Accumulating lines of evidence indicate that increased GSK-3β activity contributes to neuronal death and pathogenesis o...
Cutting through the complexities of mTOR for the treatment of stroke [0.03%]
mTOR的复杂性在卒中治疗中的作用机制及其应对策略
Kenneth Maiese
Kenneth Maiese
On a global basis, at least 15 million individuals suffer some form of a stroke every year. Of these individuals, approximately 800,000 of these cerebrovascular events occur in the United States (US) alone. The incidence of stroke in the US...
Dafin Fior Muresanu,Aurel Popa-Wagner,Adina Stan et al.
Dafin Fior Muresanu et al.
Cognitive abilities depend primarily on cerebrovascular health and aging. In this work, we examine the pathogenic mechanisms of brain dysfunction linked to vascular risk factors, insulin signaling and cerebrovascular damage and explore how ...
Phenylbutyric acid protects against spatial memory deficits in a model of repeated electroconvulsive therapy [0.03%]
苯丁酸保护电休克复发放置性记忆缺损模型小鼠的作用
Zhao-Hui Yao,Xiang Kang,Liu Yang et al.
Zhao-Hui Yao et al.
Repeated electroconvulsive therapy (rECT) is widely applied in the treatment of refractory depression. Among the side effects of rECT, memory impairment is noticeable and needs effective protection. In this study, by employing a recognized ...
Human internal jugular valve M-mode ultrasound characterization [0.03%]
人静脉内 jugular 静脉阀门 M 模式超声波特征化
Erica Menegatti,Mirko Tessari,Sergio Gianesini et al.
Erica Menegatti et al.
In humans the mechanism governing the internal jugular vein (IJV) valve opening and closure is still unclear. M-mode is used in echo-cardiology for the heart valves assessment. Sometimes it was performed also in deep peripheral veins and in...
A PPAR-β/δ agonist is neuroprotective and decreases cognitive impairment in a rodent model of Parkinson's disease [0.03%]
一种PPAR-β/δ激动剂可保护神经元并减少帕金森病动物模型中的认知障碍
Nihar R Das,Rahul P Gangwal,Mangesh V Damre et al.
Nihar R Das et al.
Parkinson's disease (PD) is associated with higher risk of cognitive impairment that may lead to memory loss, confusion, and decreased attention span. In this study, we have investigated the effect of GW0742, a PPAR-β/δ agonist in rat mod...
Basal ganglia enlarged perivascular spaces are linked to cognitive function in patients with cerebral small vessel disease [0.03%]
基底节血管周围扩大间隙与脑小血管病患者的认知功能有关
Marjolein Huijts,Annelien Duits,Julie Staals et al.
Marjolein Huijts et al.
Enlarged perivascular spaces (EPVS) are a feature of cerebral small vessel disease (cSVD) and have been related to cSVD severity. A higher number of EPVS were related to decreased cognition in healthy elderly, but this has never been invest...
Hyper-coagulable profile with elevated pro-thrombotic biomarkers and increased cerebro- and cardio-vascular disease risk exist among healthy dyslipidemic women [0.03%]
血脂异常的健康女性存在促凝和增加脑血管及心血管风险的状态
Cláudia N Ferreira,Maria G Carvalho,Helton J Reis et al.
Cláudia N Ferreira et al.
Dyslipidemia is one of the pathognomonic elements of athero-genesis, as well as cerebro- and cardio-vascular disease (CCVD). Hemostatic factors are also involved in athero-sclerosis and ischemic changes, however their relationship with disr...