Cerebral microemboli increase β-amyloid protein deposition, MMP-9, and GFAP expression in the Alzheimer`s model of APP/PS1 double transgenic mice [0.03%]
脑微栓子加重APP/PS1双转基因小鼠AD模型中β淀粉样蛋白沉积、MMP-9表达及GFAP表达
Min Ning,Yiying Wu,Xiushi Ni et al.
Min Ning et al.
We investigated the effects of cerebral arterial microemboli on amyloid β protein (Aβ) deposition in the hippocampal region of amyloid precursor protein/presenilin 1 (APP/PS1) double transgenic mice and evaluated the role of cerebral arte...
"Connecting the dots" from blood brain barrier dysfunction to neuroinflammation and Alzheimer's disease [0.03%]
“连点成线”：血脑屏障功能障碍与神经炎症及阿尔茨海默病的关系
Kenneth Maiese
Kenneth Maiese
Iron overload is associated with perihematoma edema growth following intracerebral hemorrhage that may contribute to in-hospital mortality and long-term functional outcome [0.03%]
铁过载与脑出血后 perihaematoma 水肿生长有关，可能增加院内死亡率并影响长期功能预后
Babak Bakhshayesh,Mozaffar Hosseininezhad,Seyedeh Nazanin Seyed Saadat et al.
Babak Bakhshayesh et al.
Iron overload may contribute to brain damage that involves delayed brain atrophy, edema, and neuronal cell death as well as unfavorable outcome following ischemic stroke and intracerebral hemorrhage (ICH). This prospective study was perform...
Urinary albumin to creatinine ratio as potential biomarker for cerebral microvascular disease [0.03%]
尿白蛋白肌酐比值可能是脑小血管疾病的生物标志物
Amanda L Strickland,Heidi C Rossetti,Ronald M Peshock et al.
Amanda L Strickland et al.
Elevated urinary albumin to creatinine ratio (ACR) and white matter hyperintensity (WMH) volume seen on brain MRI are measures of microvascular disease which may have shared susceptibility to metabolic and vascular insults. We hypothesized ...
Early ischemic blood brain barrier damage: a potential indicator for hemorrhagic transformation following tissue plasminogen activator (tPA) thrombolysis? [0.03%]
再灌注早期脑血屏障破坏是组织型纤溶酶原激活物溶栓后出血转化的潜在预测指标吗？
Xinchun Jin,Jie Liu,Wenlan Liu
Xinchun Jin
Tissue plasminogen activator (tPA) thrombolysis, remains to be the only United States Food and Drug Administration (FDA) approved treatment for acute ischemia stroke. However, the use of tPA has been profoundly constrained due to its narrow...
Seyed Fazel Nabavi,Alyna Turner,Olivia Dean et al.
Seyed Fazel Nabavi et al.
Post-stroke depression is an important psychological consequence of ischemic stroke, and affects around one third of stroke patients at any time post-stroke. It has a negative impact on patient morbidity and mortality, and as such developme...
Reduction in vascular endothelial growth factor expression in the superior temporal, hippocampal, and brainstem regions in Alzheimer's disease [0.03%]
阿尔茨海默病患者顶叶、海马和脑干血管内皮生长因子表达降低
John Provias,Brian Jeynes
John Provias
Fifteen Alzheimer (AD) and fifteen normative (NM) age-matched autopsy brains were analyzed in superior temporal cortex, hippocampal and brainstem samples. Vascular endothelial growth factor (VEGF) positive capillaries were quantitatively an...
Monique Michels,Lucineia G Danielski,Felipe Dal-Pizzol et al.
Monique Michels et al.
Neuroinflammation is presented in the acute phase brain damage as well as chronic diseases. Cells that are directly or indirectly involved in immune responses compose the central nervous system (CNS). Microglia are resident cells of the CNS...
Protection of blood brain barrier integrity and modulation of inflammatory mediators during treatment of pneumococcal meningitis with daptomycin or ceftriaxone [0.03%]
达托霉素或头孢曲松治疗肺炎球菌性脑膜炎时对血脑屏障完整性的保护和炎症介质的调节作用
Tatiana Barichello,Joao Carlos Nepomuceno Goncalves,Jaqueline da Silva Generoso et al.
Tatiana Barichello et al.
Pneumococcal meningitis is associated with neurologic sequelae, such as learning and memory impairment. Most recently, a nonbacteriolytic antibiotic has been investigated to minimise the inflammatory host response and prevent cognitive dama...
Microglial activation with reduction in autophagy limits white matter lesions and improves cognitive defects during cerebral hypoperfusion [0.03%]
微胶质细胞激活通过减少自噬限制脑低灌注下的白质病变并改善认知缺陷
Zhao Yang,Nan Zhang,Hanchao Shen et al.
Zhao Yang et al.
Microglial activation plays a vital role in the pathogenesis of white matter lesions (WMLs) during chronic cerebral hypo perfusion. Autophagy has been associated with both microglia survival and cell death. Yet, the role of autophagy during...