Bernhard H J Juurlink
Bernhard H J Juurlink
The dominant hypothesis in multiple sclerosis is that it is an autoimmune disease; however, there is considerable evidence that the immune attack on myelin may be secondary to a cytodegenerative event. Furthermore, the immune modulating the...
Pilar Villacampa,Virginia Haurigot,Fatima Bosch
Pilar Villacampa
Proliferative retinopathies are the leading causes of blindness in Western societies. The development of new, more efficacious treatments that take advantage of recent advances in the fields of gene and cell therapy requires further investi...
Antonio Siniscalchi,Antonello Bonci,Nicola Biagio Mercuri et al.
Antonio Siniscalchi et al.
Cocaine abuse remains a devastating medical problem for our society. Current concepts suggest that both hemorrhagic and ischemic stroke, particularly in young people, can result as a consequence of cocaine exposure. We provide an analysis o...
Low estimated glomerular filtration rate is associated with high recurrence rate and poor prognosis of hemorrhage stroke [0.03%]
估计肾小球滤过率较低与出血性卒中的高复发率和不良预后相关
Sun Kai,Qu Jiaoyan,Song Weihua et al.
Sun Kai et al.
This study investigated whether a low estimated glomerular filtration rate (eGFR) leads to a higher risk of stroke recurrence and a poor prognosis in hemorrhagic stroke patients. A total of 2000 stroke patients were recruited during 2000-20...
Programming apoptosis and autophagy with novel approaches for diabetes mellitus [0.03%]
运用新方法对糖尿病凋亡和自噬进行编程
Kenneth Maiese
Kenneth Maiese
According to the World Health Organization, diabetes mellitus (DM) in the year 2030 will be ranked the seventh leading cause of death in the world. DM impacts all systems of the body with oxidant stress controlling cell fate through endopla...
Ketamine treatment partly reverses alterations in brain derived- neurotrophic factor, oxidative stress and energy metabolism parameters induced by an animal model of depression [0.03%]
氯胺酮治疗部分逆转了抑郁模型中脑源性神经营养因子、氧化应激和能量代谢参数的改变
Gislaine Z Réus,Marcos Paulo Nacif,Helena M Abelaira et al.
Gislaine Z Réus et al.
Studies have suggested that ketamine, a nonselective NMDA receptor antagonist, could be a new drug in the treatment of major depression, but the way ketamine presents such effects remains to be elucidated. Therefore, the objective of this p...
Seyed Fazel Nabavi,Gian Carlo Tenore,Maria Daglia et al.
Seyed Fazel Nabavi et al.
Rosemary (Rosmarinus officinalis L.) is one of the most common household herbs, used as spices in a variety of foods, and employed in traditional medicine for its healing properties. Rosemary is a rich source of active antioxidant constitue...
A novel prescription for Alzheimer's disease: targeting hypercoagulable states [0.03%]
阿尔茨海默病的新疗法：针对高凝状态
Kenneth Maiese
Kenneth Maiese
Identification of target antigens of antiendothelial cell antibodies against human brain microvascular endothelial cells in healthy subjects [0.03%]
健康人脑微血管内皮细胞抗内皮细胞抗体靶抗原的鉴定
Akio Kimura,Takeo Sakurai,Nobuaki Yoshikura et al.
Akio Kimura et al.
Antiendothelial cell antibodies (AECAs) have been detected in patients who have autoimmune and inflammatory diseases. Previous studies showed that AECAs against human umbilical vein endothelial cells were detected in healthy subjects. In th...
Platelets in the Alzheimer's disease brain: do they play a role in cerebral amyloid angiopathy? [0.03%]
血小板在阿尔茨海默病脑中的作用：它们是否参与了脑淀粉样血管病？
Kathrin M Kniewallner,Daniela Ehrlich,Andreas Kiefer et al.
Kathrin M Kniewallner et al.
Alzheimer's disease (AD) is characterized by extracellular beta-amyloid plaques and intracellular tau tangles. AD-related pathology is often accompanied by vascular changes. The predominant vascular lesions in AD are cerebral amyloid angiop...