Rufinamide Improves Functional and Behavioral Deficits via Blockade of Tetrodotoxin-Resistant Sodium Channels in Diabetic Neuropathy [0.03%]
鲁非纳米德通过阻断糖尿病神经病变中河豚毒素抗性钠通道改善功能和行为缺陷
Shivsharan B Kharatmal,Jitendra N Singh,Shyam S Sharma
Shivsharan B Kharatmal
Rufinamide is a structurally novel, antiepileptic drug approved for the treatment of Lennox-Gastaut syndrome. Its mechanism of action involves inhibition of voltage-gated Na+ channels (VGSCs) with possible membrane-stabilizing effects. VGSC...
Outcome Prediction after Non-aneurysmal Non-traumatic Subarachnoid Hemorrhage [0.03%]
非创伤性非动脉瘤性蛛网膜下腔出血的预后判断
Ramazan Jabbarli,Matthias Reinhard,Roland Roelz et al.
Ramazan Jabbarli et al.
Contrary to aneurysmal bleeding, non-aneurysmal non-traumatic subarachnoid hemorrhage (NASAH) is rarely associated with unfavorable clinical outcome, cerebral infarction and vasospasm. We aimed to identify independent predictors for a poor ...
Acute and Chronic Treatments with Quetiapine Increase Mitochondrial Respiratory Chain Complex Activity in the Rat Brain [0.03%]
喹硫平急性及慢性治疗增强大鼠脑线粒体呼吸链复合物的活性
Zuleide M Ignácio,Gislaine Z Réus,Helena M Abelaira et al.
Zuleide M Ignácio et al.
Several studies have found that the molecular mechanisms of mitochondrial energy metabolism are impaired in major depressive disorder (MDD). Classic antidepressants and atypical antipsychotics can alter the function of enzymes involved in a...
VEGF Signaling Regulates Cofilin and the Arp2/3-complex within the Axonal Growth Cone [0.03%]
VEGF信号转导调控轴突生长锥内的Cofilin和肌球蛋白ADF/COF以及Arp2/3复合物
Matthias Dumpich,Hans Georg Mannherz,Carsten Theiss
Matthias Dumpich
Over the last decade, our understanding of the vascular endothelial growth factor (VEGF) has rapidly increased, becoming the focus of many investigations the world over. Besides its classical role in the vascular system, VEGF was also ident...
Paring down obesity and metabolic disease by targeting inflammation and oxidative stress [0.03%]
通过靶向炎症和氧化应激减轻肥胖和代谢性疾病
Kenneth Maiese
Kenneth Maiese
Uric acid and Cu/Zn superoxide dismutase: potential strategies and biomarkers in functional recovery of post-acute ischemic stroke patients after intensive neurorehabilitation [0.03%]
尿酸和Cu/Zn超氧化物歧化酶：急性缺血性卒中后强化神经康复的功能恢复的潜在策略及生物标志物研究
Irene Ciancarelli,Caterina Di Massimo,Daniela De Amicis et al.
Irene Ciancarelli et al.
No evidence is currently provided on the involvement of uric acid (UA) and Cu/Zn Superoxide Dismutase (Cu/Zn SOD) in functional recovery of stroke patients after neurorehabilitation. For this purpose, the relationship between UA and Cu/Zn S...
An experimental model for exudative age-related macular degeneration with choroidal neovascularization using the common marmoset [0.03%]
用于恒河猴脉络膜新生血管性老年黄斑变性的外渗模型研究
Masamitsu Shimazawa,Tomomi Masuda,Shinsuke Nakamura et al.
Masamitsu Shimazawa et al.
This study aimed to establish an experimental exudative age-related macular degeneration (AMD) model in the common marmoset (Callithrix jacchus), which is a small New World monkey. Choroidal neovascularization (CNV) was induced by laser irr...
Etanercept improves cognitive performance and increases eNOS and BDNF expression during experimental vascular dementia in streptozotocin-induced diabetes [0.03%]
依那西普改善糖尿病血管性痴呆模型小鼠认知功能并增加内皮型一氧化氮合酶及脑源性神经营养因子表达
Tijen Utkan,Yusufhan Yazir,Ayse Karson et al.
Tijen Utkan et al.
Diabetes mellitus (DM) is related to an increase in the incidence of vascular dementia. Inflammation is an important cause of endothelial dysfunction and cognitive deficits. The anti -tumor necrosis factor (TNF)-α fusion protein etanercept...
Obesity promotes oxidative stress and exacerbates sepsis-induced brain damage [0.03%]
肥胖促进氧化应激并加重脓毒症引起的脑损伤
Andriele Aparecida Vieira,Monique Michels,Drielly Florentino et al.
Andriele Aparecida Vieira et al.
Sepsis is a severe clinical syndrome in which a system-wide inflammatory response follows initial attempts to eliminate pathogens. It is not novel that in sepsis the brain is one of the first organs affected which causes an increase in morb...
Granulocyte colony-stimulating factor and bone marrow mononuclear cells for stroke treatment in the aged brain [0.03%]
粒细胞集落刺激因子和骨髓单个核细胞在脑卒中治疗中的作用
Ana-Maria Buga,Johanna Scheibe,Karoline Moller et al.
Ana-Maria Buga et al.
Ischemic stroke swiftly induces a wide spectrum of pathophysiological sequelae, particularly in the aged brain. The translational failure of experimental therapies, might partially be related to monotherapeutic approaches, not address poten...