Utilizing Ultrasound to Transiently Increase Blood-Brain Barrier Permeability, Modulate of the Tight Junction Proteins, and Alter Cytoskeletal Structure [0.03%]
利用超声波瞬时增加血脑屏障通透性、调节紧密连接蛋白并改变细胞骨架结构
Mi Jung Bae,Young Mi Lee,Yeoun Hee Kim et al.
Mi Jung Bae et al.
The central nervous system is protected by the blood-brain barrier (BBB). The tight junction (TJ) proteins claudin-5 and zonula occludens-1 (ZO-1) as well as the cytoskeletal component F-actin play key roles in maintaining homeostasis of th...
Epigenetic Changes in the Methylation Patterns of KCNQ1 and WT1 after a Weight Loss Intervention Program in Obese Stroke Patients [0.03%]
肥胖卒中患者减重干预后KCNQ1和WT1甲基化模式表观遗传学变化分析
Itziar Abete,Ana M Gómez-Úriz,María L Mansego et al.
Itziar Abete et al.
Ischemic stroke patients often show high concentrations of circulating inflammatory markers that are associated with increased risk of recurrence. Epigenetic mechanisms could be involved in obesity, inflammation and stroke. The objective of...
Sodium Butyrate, a Histone Deacetylase Inhibitor, Reverses Behavioral and Mitochondrial Alterations in Animal Models of Depression Induced by Early- or Late-life Stress [0.03%]
钠丁酸（组蛋白脱乙酰酶抑制剂）逆转由早期或晚期压力诱导的抑郁动物模型的行为和线粒体改变
Samira S Valvassori,Wilson R Resende,Josiane Budni et al.
Samira S Valvassori et al.
The aim of the present study was to evaluate the effects of sodium butyrate on depressive-like behavior and mitochondrial alteration parameters in animal models of depression induced by maternal deprivation or chronic mild stress in Wistar ...
Differential Regulation of microRNAs in Patients with Ischemic Stroke [0.03%]
缺血性卒中患者microRNA的差异表达及功能研究
Sheng-Hua Li,Sheng-You Su,Jing-Li Liu
Sheng-Hua Li
MicroRNAs have been discovered as regulators of gene expression and thus their potential in clinical disease diagnostics, prognosis and therapy is being actively pursued. MicroRNAs play an important role in atherosclerosis-related diseases,...
Combination of Local Transplantation of In Vitro Bone-marrow Stromal Cells and Pulsed Electromagnetic Fields Accelerate Functional Recovery of Transected Sciatic Nerve Regeneration: A Novel Approach in Transected Nerve Repair [0.03%]
联合局部骨髓基质细胞移植和脉冲电磁场加速坐骨神经完全断裂的再生修复：一种新的治疗方法
Rahim Mohammadi,Sirvan Mahmoodzadeh
Rahim Mohammadi
Effect of combination of undifferentiated bone marrow stromal cells (BMSCs) and pulsed electromagnetic fields (PEMF) on transected sciatic nerve regeneration was assessed in rats. A 10 mm nerve segment was excised and a vein graft was used ...
Interleukin-1β Receptor Antagonism Prevents Cognitive Impairment Following Experimental Bacterial Meningitis [0.03%]
抑制白细胞介素-1β受体可预防实验性细菌性脑膜炎后认知功能障碍
Tatiana Barichello,Jaqueline S Generoso,Lutiana R Simões et al.
Tatiana Barichello et al.
Pneumococcal meningitis is characterized by high rates of mortality and long-term cognitive impairment. In this study, we evaluated the effects of interleukin (IL)-1β receptor antagonist (IL-1Ra) on memory, cytokine, and brain-derived neur...
Perfusion-diffusion Mismatch Predicts Early Neurological Deterioration in Anterior Circulation Infarction without Thrombolysis [0.03%]
缺血核心之外的灌注缺陷预测了未溶栓的大血管闭塞急性缺血性卒中患者早期神经功能恶化的发生
Chia-Yu Hsu,Chun-Yu Cheng,Yuan-Hsiung Tsai et al.
Chia-Yu Hsu et al.
Perfusion-diffusion mismatch in magnetic resonance imaging (MRI) represents the non-core hypoperfused area in acute ischemic stroke. The mismatch has been used to predict clinical response after thrombolysis in acute ischemic stroke, but it...
Kenneth Maiese
Kenneth Maiese
Radix Angelica Sinensis Promotes Synaptic Plasticity During Cognitive Recovery in Chronically Stressed Rats [0.03%]
当归促进慢性应激大鼠认知恢复期间的突触可塑性
Min Deng,Huimin Sun,Jun Shen et al.
Min Deng et al.
The accumulation of chronic stress is associated with cognitive dysfunction. Radix Angelica Sinensis (RAS) has been shown to have neuroprotective potential for treating Alzheimer's disease and vascular dementia. However, the impact of RAS o...
Neuroprotective Effects of Agomelatine and Vinpocetine Against Chronic Cerebral Hypoperfusion Induced Vascular Dementia [0.03%]
阿戈美拉汀和长春胺对慢性脑低灌诱发的血管性痴呆的神经营养效应
Surbhi Gupta,Prabhat Singh,Brij Mohan Sharma et al.
Surbhi Gupta et al.
Chronic cerebral hypoperfusion (CCH) has been considered as a critical cause for the development of cognitive decline and dementia of vascular origin. Melatonin receptors have been reported to be beneficial in improving memory deterioration...