Platelet-derived Growth Factor Receptor-beta is Differentially Regulated in Primary Mouse Pericytes and Brain Slices [0.03%]
血小板源生长因子受体-β在原代小鼠周细胞和脑切片中的不同调控机制研究
Bianca Hutter-Schmid,Christian Humpel
Bianca Hutter-Schmid
Pericytes are perivascular cells and have heterogenous roles in the brain, such as controlling blood flow and entry of immune cells or regulating the blood-brain barrier. Platelet-derived growth factor (PDGF) receptor-beta (PDGFRβ) is high...
Carotid Endarterectomy and Carotid Artery Stenting Lead to Improved Cognitive Performance in Patients with Severe Carotid Artery Stenosis [0.03%]
重度颈动脉狭窄患者行颈动脉内膜剥脱或支架成形术可改善认知功能
Guo-Mei Shi,Teng Jiang,Hong Zhang et al.
Guo-Mei Shi et al.
In patients with severe carotid artery stenosis, the effects of carotid artery reopening, achieved either by carotid endarterectomy (CEA) or carotid artery stenting (CAS), on cognitive functions remain elusive. Herein, we conducted a prospe...
Calcium Channel Blockade and Peroxisome Proliferator Activated Receptor γ Agonism Diminish Cognitive Loss and Preserve Endothelial Function During Diabetes Mellitus [0.03%]
钙通道阻断和过氧化物酶体增殖激活受体γ激动防止糖尿病引起的学习记忆障碍和内皮细胞功能紊乱
Swati Jain,B M Sharma,Bhupesh Sharma
Swati Jain
Diabetes mellitus is considered as a main risk factor for vascular dementia. In the past, we have reported the induction of vascular dementia (VaD) by experimental diabetes. This study investigates the efficacy of a nifedipine, a calcium ch...
The Immune System and the Brain: Crosstalk with a Broad Impact From Host Defense to Cognition [0.03%]
免疫系统与大脑：从宿主防御到认知的广泛影响的相互作用
Kenneth Maiese
Kenneth Maiese
Poor Prognostic Outcome in Cerebral Venous Sinus Thrombosis Associated with Dyskinesia and Elevated Platelet Volume [0.03%]
与异动症和血小板体积增大相关的脑静脉窦血栓形成的不良预后结局
Shousen Wang,Bingyang Xu,Qingshuang Zhao et al.
Shousen Wang et al.
Although about 80% of patients with cerebral venous sinus thrombosis have a good prognosis, some patients develop severe complications and a small proportion do not survive. The study included patients who had been diagnosed with cerebral v...
NF-κB Inhibition Resolves Cognitive Deficits in Experimental Type 2 Diabetes Mellitus through CREB and Glutamate/GABA Neurotransmitters Pathway [0.03%]
NF-κB抑制通过CREB和谷氨酸/γ-氨基丁酸神经递质通路改善实验性2型糖尿病认知障碍
Ashok Kumar Datusalia,Shyam Sunder Sharma
Ashok Kumar Datusalia
Diabetes is associated with deficits in memory and cognitive functions and sustained inflammation. Recently, involvement of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) has been postulated in many cognitive functi...
Assessment of Vascular Geometry for Bilateral Carotid Artery Ligation to Induce Early Basilar Terminus Aneurysmal Remodeling in Rats [0.03%]
双侧颈动脉结扎诱导大鼠早发小脑天窗动脉瘤重塑的血管几何评估
Vincent Matthew Tutino,Nicholas Liaw,Joseph Andrew Spernyak et al.
Vincent Matthew Tutino et al.
Bilateral common carotid artery (CCA) ligation in rabbits is a model for basilar terminus (BT) aneurysm formation. We asked if this model could be replicated in rats. Fourteen female Sprague Dawley rats underwent bilateral CCA ligation (n=8...
Identification of Inflammatory, Metabolic, and Cell Survival Pathways Contributing to Cerebral Small Vessel Disease by Postmortem Gene Expression Microarray [0.03%]
利用死后基因表达微阵列识别参与脑小血管病的炎症、代谢和细胞生存途径
Marie-Françoise Ritz,Caspar Grond-Ginsbach,Manja Kloss et al.
Marie-Françoise Ritz et al.
Cerebral small-vessel disease (SVD) is characterized by periventricular white matter (WM) changes and general brain atrophy. SVD is prevalent in elderly individuals and is frequently associated with the development of vascular dementia (VaD...
Cyclooxygenase-2 and Prostaglandin E2 are Associated with Middle Cerebral Artery Occlusion and Hemorrhage in Patients with Moyamoya Disease [0.03%]
moyamoya病患者大脑中动脉闭塞及出血与环氧化酶-2和前列腺素E2的关系研究
Jianjian Zhang,Zhongwei Xiong,Sheng Wang et al.
Jianjian Zhang et al.
Some inflammatory proteins, such as cyclooxygenase (COX)-2 and prostaglandin (PG) E2 are hypothesized to be implicated in the development of moyamoya disease (MMD). However, the functional roles of COX-2/PGE2 in the pathogenesis of MMD rema...
Reduction in Estimated Glomerular Filtration Rate (eGFR) Results in an Increased Risk of Spontaneous Hemorrhagic Transformation in Patients with Large-artery Atherosclerosis Stroke [0.03%]
估算肾小球滤过率(eGFR)降低可增加大动脉粥样硬化性脑梗死患者自发性出血转化风险
Bian Liu,Deren Wang,Zilong Hao et al.
Bian Liu et al.
The association between chronic kidney disease and spontaneous hemorrhagic transformation (HT) in patients with acute ischemic stroke is seldom reported. We performed this study to identify whether reduced estimated glomerular filtration ra...