Magnetic Resonance Imaging of Plaque Burden in Vascular Walls of the Middle Cerebral Artery Correlates with Cerebral Infarction [0.03%]
颈内动脉粥样硬化斑块负荷的磁共振成像与脑梗死的关系研究
Fei Li,Qian-Xue Chen,Zhi-Biao Chen et al.
Fei Li et al.
Intracranial atherosclerosis may be related to the risk of ischemic stroke. High-resolution magnetic resonance imaging (H-R MRI) makes it possible to measure the intracranial atheroma in vivo. The aim of this study was to evaluate the plaqu...
Fingolimod (FTY720) Reduces Cortical Infarction and Neurological Deficits During Ischemic Stroke Through Potential Maintenance of Microvascular Patency [0.03%]
芬戈莫德通过维持微血管通畅减少脑梗死皮层梗死和神经缺陷
Michael K Schuhmann,Milos Krstic,Christoph Kleinschnitz et al.
Michael K Schuhmann et al.
Fingolimod (FTY720) reduces infarct volume and improves neurological deficits in different rodent stroke models by modulating inflammatory and immune processes. However, studies on FTY720 regarding its non-immunological efficacy on ischemic...
Selective 5-HT7 Receptor Activation May Enhance Synaptic Plasticity Through N-methyl-D-aspartate (NMDA) Receptor Activity in the Visual Cortex [0.03%]
选择性5-羟色胺7型受体激活可能通过视觉皮层中的N-甲基-D天冬氨酸（NMDA）受体活性增强突触可塑性
Kangjian Xiang,Xuefei Zhao,Youjun Li et al.
Kangjian Xiang et al.
Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that modulates N-methyl-D-aspartate (NMDA) receptor activity by binding to several different 5-HT receptor subtypes. In the present study, we used whole-cell patch-clamp...
Intracranial Collateral Flow Estimated by Color Velocity Imaging Quantification Ultrasound: A Protector of Recurrent Stroke in Patient with Carotid Stenosis? [0.03%]
彩色血流成像定量超声估算颅内代偿血管形成情况：在颈动脉狭窄患者中预防复发性卒中的保护作用？
Hui Fang,Xiang Yan Chen,Bo Song et al.
Hui Fang et al.
Stroke patients with carotid disease have a high risk of recurrence of disease. By measuring cerebral blood flow volume (BFV) using extracranial duplex technique for clinical estimation of intracranial collaterals, we aimed to investigate t...
High Serum Alkaline Phosphatase Levels in Relation to Multi-Cerebral Microbleeds in Acute Ischemic Stroke Patients with Atrial Fibrillation and/or Rheumatic Heart Disease [0.03%]
急性缺血性卒中患者房颤和/或风湿性心脏病与多发脑微出血相关的高血清碱性磷酸酶水平
Junfeng Liu,Deren Wang,Jie Li et al.
Junfeng Liu et al.
Elevated alkaline phosphatase (ALP) levels are associated with cerebral small vascular diseases, such as silent brain infarction and cerebral white matter hyperintensity (cWMH), but few prospective data are available for cerebral microbleed...
TREM2 p.H157Y Variant and the Risk of Alzheimer's Disease: A Meta-Analysis Involving 14,510 Subjects [0.03%]
APOE基因分型中国专家共识(2015)及相关研究进展——阿尔茨海默病载脂蛋白E ε4等位基因携带者TREM2 p.H157Y变异与AD风险的meta分析及遗传相关性研究涉及14,510名受试者
Teng Jiang,Jian-Kang Hou,Qing Gao et al.
Teng Jiang et al.
We recently revealed that p.H157Y (rs2234255), a rare coding variant of triggering receptor expressed on myeloid cells 2 gene (TREM2), was associated with Alzheimer's disease (AD) susceptibility in Han Chinese. Contrastingly, although p.H15...
Erythropoietin and mTOR: A "One-Two Punch" for Aging-Related Disorders Accompanied by Enhanced Life Expectancy [0.03%]
促红细胞生成素和mTOR：“一记重拳”防治伴行寿命延长的老年疾病
Kenneth Maiese
Kenneth Maiese
Life expectancy continues to increase throughout the world, but is accompanied by a rise in the incidence of non-communicable diseases. As a result, the benefits of an increased lifespan can be limited by aging-related disorders that necess...
TRPA1 and TRPM8 Receptors May Promote Local Vasodilation that Aggravates Oxaliplatin-Induced Peripheral Neuropathy Amenable to 17β-Estradiol Treatment [0.03%]
雄激素受体TRPA1和TRPM8可能促进局部血管舒张并加重奥沙利铂诱导的外周神经病的症状，适合用雌二醇治疗
Yuwei Pan,Fengguo Chen,Si Huang et al.
Yuwei Pan et al.
Oxaliplatin is a widely used chemotherapeutic agent that induces both acute and chronic peripheral neuropathy. Based on previous research indicating that estrogen replacement may attenuate some forms of pain in ovariectomized animals, we ex...
An Updated Meta-Analysis of the Efficacy and Safety of Acupuncture Treatment for Vascular Cognitive Impairment Without Dementia [0.03%]
针刺治疗无痴呆血管性认知障碍有效性和安全性的最新meta分析
Deng Min,Wang Xu-Feng
Deng Min
Vascular cognitive impairment with no dementia (VCIND) refers to a transitional state and will progress to dementia. Currently, effective medicines to control VCIND are surprisingly scarce. Acupuncture intervention is frequently advocated a...