Tanshinone IIA Protects Hippocampal Neuronal Cells from Reactive Oxygen Species Through Changes in Autophagy and Activation of Phosphatidylinositol 3-Kinase, Protein Kinas B, and Mechanistic Target of Rapamycin Pathways [0.03%]
丹参酮ⅡA通过调节自噬及Akt、mTOR信号通路保护海马神经元免受活性氧损伤
Yingchun Zhu,Qiqiang Tang,Guopin Wang et al.
Yingchun Zhu et al.
Background: Tanshinone IIA is a key active ingredient of danshen, which is derived from the dried root or rhizome of Salviae miltiorrhizae Bge. The tanshinone IIA has protective effects against the focal cerebral ischemic...
Clinical Significance of the Sympathetic Nervous System in the Development and Progression of Pulmonary Arterial Hypertension [0.03%]
交感神经系统在肺动脉高血压发病及进展中的作用及其临床意义
Ru-Xia Liu,Qian Luo,Hui Qiao et al.
Ru-Xia Liu et al.
Background: Pulmonary arterial hypertension (PAH) is defined as a complex disease of clinically characterized by elevated pulmonary pressure eventually resulting in right heart failure and premature death. To date, PAH st...
Clinical Significance of the Sympathetic Nervous System in the Development and Progression of Pulmonary Arterial Hypertension [0.03%]
自主神经系统在肺动脉高压发生发展中的作用及意义
Ru-Xia Liu,Qian Luo,Hui Qiao et al.
Ru-Xia Liu et al.
Background: Pulmonary arterial hypertension (PAH) is defined as a complex disease of clinically characterized by elevated pulmonary pressure eventually resulting in right heart failure and premature death. To date, PAH st...
In Models of Intracerebral Hemorrhage, Rivaroxaban is Superior to Warfarin to Limit Blood Brain Barrier Disruption and Hematoma Expansion [0.03%]
在脑出血模型中，利伐沙班优于华法林可限制血脑屏障破坏和血肿扩大
Shigenobu Sawada,Yoko Ono,Yusuke Egashira et al.
Shigenobu Sawada et al.
Background: Intracerebral hemorrhage (ICH) during oral anticoagulation therapy with an oral vitamin K epoxidase reductase such as warfarin is a life-threatening complication. However, whether direct oral anticoagulants (D...
In Models of Intracerebral Hemorrhage, Rivaroxaban is Superior to Warfarin to Limit Blood Brain Barrier Disruption and Hematoma Expansion [0.03%]
在脑出血模型中，利伐沙班优于华法林可限制血脑屏障破坏和颅内血肿扩大
Shigenobu Sawada,Yoko Ono,Yusuke Egashira et al.
Shigenobu Sawada et al.
Background: Intracerebral hemorrhage (ICH) during oral anticoagulation therapy with an oral vitamin K epoxidase reductase such as warfarin is a life-threatening complication. However, whether direct oral anticoagulants (D...
Correlation between Decreased Parasympathetic Activity and Reduced Cerebrovascular Reactivity in Patients with Lacunar Infarct [0.03%]
局灶性脑梗死患者副交感神经活性降低与脑血管反应性减低相关性研究
Kannakorn Intharakham,Kesorn Suwanprasert,Sombat Muengtaweepongsa
Kannakorn Intharakham
Reduced cerebrovascular reactivity (CVR) was found in patients with recent lacunar infarct. However, its mechanisms were controversial. The breath holding maneuver as a vasodilatory stimulus is clinically useful for an estimation of cerebro...
Kenneth Maiese
Kenneth Maiese
Congenital Muscular Dystrophy 1D Causes Matrix Metalloproteinase Activation And Blood-Brain Barrier Impairment [0.03%]
先天性肌营养不良1D导致基质金属蛋白酶活化和血脑屏障损伤
Aryadnne L Schactae,Daphne Palmas,Monique Michels et al.
Aryadnne L Schactae et al.
Congenital Muscular Dystrophy type 1D (CMD1D) is characterized by an abnormal glycosylation of α-DG (α-dystroglycan) and is associated to the central nervous system (CNS) abnormalities such as cognitive impairment. The purpose of the rese...
Strong Association of Lipid Metabolism Related MicroRNA Binding Sites Polymorphisms with the Risk of Late Onset Alzheimer's Disease [0.03%]
与阿尔茨海默病发病风险相关的脂质代谢相关microRNA结合位点多态性分析
Lin Tan,Ang Xing,Da-Long Zhao et al.
Lin Tan et al.
Although altered lipid metabolism has been extensively implicated in the pathogenesis of late onset Alzheimer's disease (LOAD) through cell biological and epidemiological studies, genetic studies linking lipid metabolism and LOAD are still ...
Harnessing the Power of SIRT1 and Non-coding RNAs in Vascular Disease [0.03%]
SIRT1和非编码RNA在血管疾病中的作用及机制研究进展
Kenneth Maiese
Kenneth Maiese
Noncommunicable diseases (NCDs) contribute to a significant amount of disability and death in the world. Of these disorders, vascular disease is ranked high, falls within the five leading causes of death, and impacts multiple other disease ...