Remote Ischemic Conditioning Improves Cognitive Function During Cerebral Vascular Injury Through the Induction of Autophagy [0.03%]
远程缺血适应通过诱导自噬改善脑血管损伤大鼠的认知功能
Hongjuan Wang,Qinglin Zhang,Yang Xu et al.
Hongjuan Wang et al.
Background: The most valid model for vascular cognitive impairment (VCI) is the mouse bilateral common carotid artery stenosis (BCAS), whose behavioral outcomes are supposedly affected by the remote ischemic conditioning ...
Triamcinolone Acetonide Suppresses Inflammation and Facilitates Vascular Barrier Function in Human Retinal Microvascular Endothelial Cells [0.03%]
曲安奈德抑制炎症并促进人视网膜微血管内皮细胞的血管屏障功能
Shunsuke Imai,Tomohiro Otsuka,Akira Naito et al.
Shunsuke Imai et al.
Background: Diabetic macular edema (DME) is resulted from the retinal microvascular leakage that accompanies the breakdown of blood-retinal barrier. Triamcinolone acetonide (TA) is a therapeutic agent for DME, but since t...
The Wnt/β-catenin Signalling Pathway Inhibitor Sclerostin is a Biomarker for Early Atherosclerosis in Obesity [0.03%]
肥胖早期动脉粥样硬化骨硬化素是一个标志物及功能分子
Djordje S Popovic,Milena Mitrovic,Dragana Tomic-Naglic et al.
Djordje S Popovic et al.
Background: Sclerostin is an inhibitor of the wingless-type mouse mammary tumor virus integration site family/β-catenin signalling pathway (WβcSP), which plays an important role in bone metabolism and in vascular biolog...
The Hippocampal Autophagic Machinery is Depressed in the Absence of the Circadian Clock Protein PER1 that may Lead to Vulnerability During Cerebral Ischemia [0.03%]
无昼夜钟蛋白PER1时海马自噬装置受到抑制，导致脑缺血易损性增加
Abdelhaq Rami,Julia Fekadu,Oliver Rawashdeh
Abdelhaq Rami
Background: Autophagy is an intracellular bulk self-degrading process in which cytoplasmic contents of abnormal proteins and excess or damaged organelles are sequestered into autophagosomes, and degraded upon fusion with ...
Enhanced Risk for Specific Somatic Myeloproliferative Neoplastic Mutations in Patients with Stroke [0.03%]
卒中患者的特定体细胞髓系肿瘤突变增强的风险
Chih-Cheng Chen,Chia-Chen Hsu,Cih-En Huang et al.
Chih-Cheng Chen et al.
Background: Somatic mutations of Janus kinase 2 (JAK2V617F), calreticulin (CALR), and myeloproliferative leukemia virus oncogene (MPL) are the major clonal molecules that drive the pathogenesis of myeloproliferative neopl...
Prolonged Perfusion Predicts Recurrent Ischemic Stroke but not Transient Ischemic Attack in Patients with Symptomatic Intracranial Stenosis [0.03%]
症状性颅内狭窄患者中长时间的灌注异常与卒中复发有关，而非一过性脑缺血发作
Linfang Lan,Xinyi Leng,Vincent Ip et al.
Linfang Lan et al.
Background: Intracranial arterial stenosis (ICAS) is the dominant cause for ischemic stroke worldwide, with hemodynamic compromise as a crucial contributor. Prolonged perfusion is commonly observed in ICAS patients on CT ...
MiR-106a Associated with Diabetic Peripheral Neuropathy Through the Regulation of 12/15-LOX-meidiated Oxidative/Nitrative Stress [0.03%]
miR-106a通过调节12/15-LOX介导的氧化/一氧化氮应激与糖尿病外周神经病变相关性研究
Yuanbo Wu,Dandan Xu,Xiang Zhu et al.
Yuanbo Wu et al.
Background: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes with a complex pathogenesis. Study has reported that oxidative stress and nitrative stress are all involved in the DPN. However, the me...
Li Gao,Teng Jiang,Xiaoying Yao et al.
Li Gao et al.
Alzheimer's disease (AD) is the most common form of dementia, which has been currently considered as a genetically complex disorder caused by a combination of environmental and genetic risk factors. Previous studies have reported that trigg...
MicroRNA-130b Promotes Wear Particle-Induced Osteolysis via Downregulating Frizzled-Related Protein (FRZB) [0.03%]
微粒通过下调分泌型蛋形素促进骨溶解
De-Zhi Zheng,Yan-Min Bu,Lei Wang et al.
De-Zhi Zheng et al.
Periprosthetic osteolysis induced by wear particles can lead to aseptic loosening, one main reason of arthroplasty failure. However, the role of microRNA-130b (miR-130b) in particle-induced osteolysis (PIO) has not been explored yet. In thi...
Fenofibrate Increases Heme Oxygenase 1 Expression and Astrocyte Proliferation While Limits Neuronal Injury During Intracerebral Hemorrhage [0.03%]
苯扎贝特促进血红素氧合酶1表达及星形胶质细胞增殖并限制脑出血引起的神经元损伤
Yan Wang,Min Yu,Yue Ma et al.
Yan Wang et al.
Peroxisome proliferator-activated receptors alpha (PPARα) is a therapy target in atherosclerosis and cardiovascular diseases. However, anti-inflammatory effects of PPARα in intracerebral hemorrhage (ICH) remain unknown. We investigated th...