Forkhead Transcription Factors: Formulating a FOXO Target for Cognitive Loss [0.03%]
FOXO转录因子：针对认知功能下降靶向作用的研究
Kenneth Maiese
Kenneth Maiese
Background: With almost 47 million individuals worldwide suffering from some aspect of dementia, it is clear that cognitive loss impacts a significant proportion of the global population. Unfortunately, definitive treatme...
Yaru Zhang,Li Sun
Yaru Zhang
Cystatin C (CysC), a cysteine protease inhibitor, has been widely proven to be a highly sensitive biomarker to predict the kidney function. The similarity of the renal and cerebral small vessels has awakened a surge of studies suggesting th...
Post-treatment with a Hydrogen Sulfide Donor Limits Neuronal Injury and Modulates Potassium Voltage-gated Channel Subfamily D Member 2 (Kv4.2) and Potassium Channel Interacting Protein 3 (KChIP3) During Transient Global Cerebral Ischemia [0.03%]
硫化氢供体后处理限制缺血性脑损伤并调节 Kv4.2 和 KChIP3 在短暂性全脑缺血期间的表达
Cheng Ping Bai,ChenLiang Zhao,Lijuan Shen
Cheng Ping Bai
Background: Although the neuroprotective effect of sodium hydrosulfide (NaHS, a hydrogen sulfide donor) pretreatment has been revealed, the effect of NaHS post-conditioning remains largely unknown. ...
miR-132 Down-regulates Methyl CpG Binding Protein 2 (MeCP2) During Cognitive Dysfunction Following Chronic Cerebral Hypoperfusion [0.03%]
脑慢性低灌注后认知功能损伤过程中 miR-132通过降低 MeCP2表达水平参与发病机制
Zhao-Hui Yao,Xiao-Li Yao,Yong Zhang et al.
Zhao-Hui Yao et al.
Background: Chronic Cerebral Hypoperfusion (CCH) is an important vascular risk factor for vascular-related dementia cognitive impairment and there are no effective measures for the prevention and treatment of cognitive de...
Salvianolate Blocks Apoptosis During Myocardial Infarction by Down Regulating miR-122-5p [0.03%]
水飞蓟宾通过下调miR-122-5p抑制心肌梗死中凋亡作用
Jingyang Lin,Xiaochun Zheng
Jingyang Lin
Background: Recent studies have provided evidence that microRNAs (miRNAs), as a potential biomarker, were involved in the regulation of gene expression in Myocardial Infarction (MI). This study aimed to highlight the role...
Cerebral Small Vessel Disease is Associated with Genetic Variations in CYP2J [0.03%]
脑小血管疾病与CYP2J基因变异有关
Ming Yao,Daping Lv,Jiajia Huo et al.
Ming Yao et al.
Background: Cerebral Small Vessel Disease (SVD) can cause cognitive impairment, disability and dementia. While it is still unclear about the pathogenesis of SVD, several risk factors of SVD have been identified, and studi...
Blood-brain Barrier Disruption Leads to Postoperative Cognitive Dysfunction [0.03%]
血脑屏障破坏导致术后认知功能障碍
Bin Wang,Siyuan Li,Xipeng Cao et al.
Bin Wang et al.
Background: Postoperative Cognitive Dysfunction (POCD) has received considerable attention as one of the main postoperative complications. The underlying mechanism of POCD in elderly subjects has not been fully elucidated...
Cerebral Artery Vasoconstriction is Endothelin-1 Dependent Requiring Neurogenic and Adrenergic Crosstalk [0.03%]
脑动脉血管收缩由内皮素-1介导，需要神经和肾上腺素相互作用
Roel H L Haeren,Sieuwke A Hartmans,Jo De Mey et al.
Roel H L Haeren et al.
Background: The regulation of cerebral arterial vasomotor tone involves several mechanisms. The role of sympathetic nerves and the adrenergic neurotransmitter, noradrenaline (NA), has been the subject of debate for decade...
Asymmetric Cerebrovascular Collateral Supply Affects Cognition in Patients with Unilateral Carotid Artery Stenosis [0.03%]
颈动脉狭窄患者脑血管侧支灌注的不对称性影响认知功能
Kuo-Lun Huang,Ting-Yu Chang,Chien-Hung Chang et al.
Kuo-Lun Huang et al.
Background: The time to maximum of the residue function (TMax) has been employed to identify the penumbra in acute ischemic stroke. Cognitive impairment in patients with Carotid Artery Stenosis (CAS) has been attributed t...
Plasma Exosomal miR-422a and miR-125b-2-3p Serve as Biomarkers for Ischemic Stroke [0.03%]
血浆外泌体miR-422a和miR-125b-2-3p作为缺血性卒中的生物标志物
Dong-Bin Li,Jing-Li Liu,Wei Wang et al.
Dong-Bin Li et al.
Background: MircroRNA (MiRNA) levels are associated with disease pathophysiology and are high in plasma exosomes. Plasma exosomal miRNAs serve as potential therapeutic targets and diagnosis biomarkers in some diseases but...