ERK/MAP Kinase Activation is Evident in Activated Microglia of the Striatum and Substantia Nigra in an Acute and Chronically-Induced Mouse Model of Parkinson's Disease [0.03%]
在急性及慢性诱发的小鼠帕金森病模型的纹状体和黑质活化小胶质细胞中ERK/MAP激酶激活明显
Sumit Sarkar,Edward Lu,James Raymick et al.
Sumit Sarkar et al.
Introduction: Parkinson's Disease (PD) is a debilitating, age-related disorder characterized by selective degeneration of dopaminergic neurons in the midbrain substantia nigra (SNc). Dopaminergic neurons originating in th...
Are Cerebral Perfusion and Atrophy Linked in Multiple Sclerosis? Evidence for a Multifactorial Approach to Assess Neurodegeneration [0.03%]
多发性硬化中脑灌注和萎缩相关吗？评估神经退行性的多种方法证据
Maria Marcella Laganá,Laura Mendozzi,Laura Pelizzari et al.
Maria Marcella Laganá et al.
Background: Grey Matter (GM) atrophy has been extensively described in Multiple Sclerosis (MS) patients, while cerebral hypoperfusion has been less consistently reported. Since hypoperfusion might be related to atrophy, w...
Kenneth Maiese
Kenneth Maiese
MicroRNA-490-5P Targets CCND1 to Suppress Cellular Proliferation in Glioma Cells and Tissue Through Cell Cycle Arrest [0.03%]
microRNA-490-5p通过细胞周期阻滞抑制胶质瘤细胞和组织中CCND1靶点的增殖
Long Zhao,Xiaoping Tang,Renguo Luo et al.
Long Zhao et al.
Background: Glioma is a type of tumor that starts in the glial cells of brain and spine. However, the underlying molecular mechanisms of miRNAs dysregulation in glioma initiation and progression is largely unclear. ...
Calcineurin Inhibition and Protein Kinase A Activation Limits Cognitive Dysfunction and Histopathological Damage in a Model of Dementia of the Alzheimer's Type [0.03%]
钙调磷酸酶抑制和蛋白激酶A活化可限制阿尔茨海默型痴呆模型的认知障碍及组织病理损伤
Amit Kumar,Nirmal Singh
Amit Kumar
Aim: The aim of the present work was to explore the outcome of combination of Calcineurin (CaN) inhibitor and Protein Kinase A (PKA) activator, in mouse models of experimental dementia. ...
Curcumin Reduces Neuronal Loss and Inhibits the NLRP3 Inflammasome Activation in an Epileptic Rat Model [0.03%]
姜黄素减少神经元损失并抑制癫痫大鼠模型中NLRP3炎性小体的激活
Qianchao He,Lingfei Jiang,Shanshan Man et al.
Qianchao He et al.
Background: Epilepsy is a chronic neurological disorder affecting an estimated 50 million people worldwide. Emerging evidences have accumulated over the past decades supporting the role of inflammation in the pathogenesis...
Cerebral Inflow and Outflow Discrepancies in Severe Sudden Sensorineural Hearing Loss [0.03%]
重度突发性特发性感音神经性听力损失的脑血流灌注和流出不匹配现象
Andrea Ciorba,Mirko Tessari,Manuela Mazzoli et al.
Andrea Ciorba et al.
The aim of this study is to evaluate whether cerebral inflow and outflow abnormalities, assessed by the means of a validated ultrasound model, could be associated with Sudden Sensorineural Hearing Loss (SSNHL). According to Clark, a total o...
Reduced Hemoglobin Levels Combined with an Increased Plasma Concentration of Vasoconstrictive endothelin-1 are Strongly Associated with Poor Outcome During Acute Ischemic Stroke [0.03%]
急性缺血性卒中期间低血红蛋白水平合并收缩血管的血浆内皮素-1浓度升高与不良预后密切相关
Agnieszka Meller,Monika Golab-Janowska,Edyta Paczkowska et al.
Agnieszka Meller et al.
The association of poor outcome and mortality with low levels of hemoglobin (Hb) and hematocrit (HcT) in patients admitted after acute Ischemic Stroke (IS) was recently demonstrated. The mechanisms behind this still remain unclear. Our stud...
Pivotal Pathogenic and Biomarker Role of Chlamydia Pneumoniae in Neurovascular Diseases [0.03%]
肺炎衣原体在神经血管疾病中的关键致病和生物标志物作用
Seidu A Richard
Seidu A Richard
Chlamydia Pneumoniae (C. Pn) is an obligatory intracellular bacterium that is associated with respiratory tract infections like pneumonia, pharyngitis and bronchitis. It has also been implicated in cerebrovascular (stroke) as well as cardio...
Recombinant Tissue Plasminogen Activator in Acute Ischemic Stroke Patients Receiving Thrombectomy: Standard or Low Dose Therapy? [0.03%]
急性缺血性卒中接受取栓患者的重组组织型纤溶酶原激活剂治疗：标准剂量或低剂量？
Chun-Hsien Lin,Chi-Hung Liu,Alvin Yi-Chou Wang et al.
Chun-Hsien Lin et al.
Background: We compared the clinical outcomes of low and standard dose recombinant tissue Plasminogen Activator (rtPA) treatment in Acute Ischemic Stroke (AIS) patients receiving Endovascular Mechanical Thrombectomy (EVT)...