Inhibition of Autophagy Potentiated Hippocampal Cell Death Induced by Endoplasmic Reticulum Stress and its Activation by Trehalose Failed to be Neuroprotective [0.03%]
自噬抑制加重内质网应激诱导的海马神经元死亡及糖元酶激活未能发挥神经保护作用
Luisa Halbe,Abdelhaq Rami
Luisa Halbe
Introduction: Endoplasmic reticulum (ER) stress induced the mobilization of two protein breakdown routes, the proteasomal- and autophagy-associated degradation. During ERassociated degradation, unfolded ER proteins are tr...
Increased Neutrophil-to-lymphocyte Ratios are Associated with Greater Risk of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke [0.03%]
急性缺血性卒中患者较高的中性粒细胞/淋巴细胞比率与出血转化风险增加相关
Quhong Song,Yisong Li,Yanan Wang et al.
Quhong Song et al.
Background and purpose: Leukocyte is currently known as a potential risk factor for symptomatic intracranial hemorrhage after reperfusion therapy, but there is little evidence on whether leukocyte is associated with the o...
Combining Diffusion-Weighted Imaging Patterns with ABCD2 Score Predicts Stroke Risk after Transient Ischemic Attack [0.03%]
结合弥散加权成像模式和ABCD2评分预测短暂性脑缺血发作后的卒中风险
Lulu Pei,Bo Song,Hui Fang et al.
Lulu Pei et al.
Background: Recent studies indicated that multiple acute infarctions on Diffusion- Weighted Imaging (DWI) were associated with a higher risk of stroke. Ob...
Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer's Disease [0.03%]
沉默信息调节因子2相关酶(SIRT): 开发用于治疗与衰老相关的记忆力减退和阿尔茨海默病的创新疗法
Kenneth Maiese
Kenneth Maiese
The world's population continues to age at a rapid pace. By the year 2050, individuals over the age of 65 will account for sixteen percent of the world's population and life expectancy will increase well over eighty years of age. Accompanie...
Gender-Specific Relationship Between Uric Acid Levels and Prognosis After Cerebral Venous Thrombosis [0.03%]
尿酸水平与 cerebral venous thrombosis 的预后关系的性别差异分析
Bo Song,Kai Liu,Yuan Gao et al.
Bo Song et al.
Background: Uric Acid (UA) has been known to play a neuroprotective role in ischemic stroke patients. However, the relationship between UA levels and prognosis in patients with Cerebral Venous Thrombosis (CVT) has not bee...
Blood Pressure and the Risk of Dementia: A Dose-Response Meta-Analysis of Prospective Studies [0.03%]
前瞻性研究的剂量反应元分析：血压与痴呆风险的关系
Zuo-Teng Wang,Wei Xu,Hui-Fu Wang et al.
Zuo-Teng Wang et al.
Background: A number of epidemiological studies have revealed a controversial correlation between Blood Pressure (BP) and the risk of dementia, hindering translation of research into preventative practice. ...
9.4T Magnetic Resonance Imaging of the Mouse Circle of Willis Enables Serial Characterization of Flow-Induced Vascular Remodeling by Computational Fluid Dynamics [0.03%]
9.4T小鼠大脑动脉环磁共振成像及计算流体动力学分析血管重构效应
Vincent M Tutino,Hamidreza Rajabzadeh-Oghaz,Anusha R Chandra et al.
Vincent M Tutino et al.
Background: The neurovasculature dynamically responds to changes in cerebral blood flow by vascular remodeling processes. Serial imaging studies in mouse models could help characterize pathologic and physiologic flow-indu...
Elevated Serum Human Cytomegalovirus IgM Levels in the Acute Phase of Ischemic Stroke are Associated with Increased Risk of Death and Major Disability [0.03%]
急性缺血性卒中早期人巨细胞病毒IgM水平与死亡和重度残疾风险的关系
Chenhuan Zhang,Ping Huang,Peipei Zhang et al.
Chenhuan Zhang et al.
Background: There was a lack of studies on the association between Human Cytomegalovirus (HCMV) infection and prognosis of ischemic stroke, although it was indicated that human cytomegalovirus DNA has played a role in sev...
Multicenter Study
Current neurovascular research. 2018;15(4):305-311. DOI:10.2174/1567202616666181123150917 2018
Min Tang,Fangping He,Li Ma et al.
Min Tang et al.
Bradykinin (BK) is a major kinin substance in the Kallikrein-Kinin System (KKS) that acts in conjunction with target cell bradykinin receptors and is involved in a variety of systems and organs. Functional regulation and pathophysiological ...
Kai Shen,Quangao Mao,Xiaoqin Yin et al.
Kai Shen et al.
Background: While the NOD-Like Receptor Protein-3 (NLRP3) inflammasome is involved in a variety of nervous system diseases, its role in epilepsy still needs to be further investigated. ...