Forkhead Box O1-p21 Mediates Macrophage Polarization in Postoperative Cognitive Dysfunction Induced by Sevoflurane [0.03%]
FOXO1-p21介导四氯化碳麻醉诱导术后认知功能障碍小胶质细胞极化的作用及机制研究
Jun-Bao Fu,Zhi-Hua Wang,Yong-Ying Ren
Jun-Bao Fu
Purpose: The current study was conducted in order to investigate the role of Forkhead box O1 and p21-mediated macrophage polarization in postoperative cognitive dysfunction induced by sevoflurane. ...
MiR-335-5p Inhibits β-Amyloid (Aβ) Accumulation to Attenuate Cognitive Deficits Through Targeting c-jun-N-terminal Kinase 3 in Alzheimer's Disease [0.03%]
微RNA-335-5p通过靶向c-Jun氨基末端激酶3抑制阿尔茨海默病中的β淀粉样蛋白(Aβ)蓄积以改善认知缺陷
Dan Wang,Zhifu Fei,Song Luo et al.
Dan Wang et al.
Objective: Alzheimer's disease (AD), also known as senile dementia, is a common neurodegenerative disease characterized by progressive cognitive impairment and personality changes. Numerous evidences have suggested that m...
MicroRNA (miR)-429 Promotes Inflammatory Injury by Targeting Kruppel-like Factor 4 (KLF4) in Neonatal Pneumonia [0.03%]
微小核糖核酸-miR-429通过靶向Krüppel样转录因子4导致新生儿肺炎炎性损伤加重
Lan Zhang,HuanLi Yan,Huiping Wang et al.
Lan Zhang et al.
Background: Neonatal pneumonia is a common disease in the neonatal period with a high incidence and death. This study aimed to investigate the molecular mechanism and effect of microRNA (miR)-429 in neonatal pneumonia. ...
Evaluation of Two Fast Virtual Stenting Algorithms for Intracranial Aneurysm Flow Diversion [0.03%]
两种颅内动脉瘤血流导向虚拟支架的快速算法评估研究
Saeb R Lamooki,Vincent M Tutino,Nikhil Paliwal et al.
Saeb R Lamooki et al.
Background: Endovascular treatment of intracranial aneurysms (IAs) by flow diverter (FD) stents depends on flow modification. Patient-specific modeling of FD deployment and computational fluid dynamics (CFD) could enable ...
MiR-340 Reduces the Accumulation of Amyloid-β Through Targeting BACE1 (β-site Amyloid Precursor Protein Cleaving Enzyme 1) in Alzheimer's Disease [0.03%]
microRNA-340通过靶向BACE1减少阿尔茨海默病中淀粉样蛋白-β的积累
Xianpei Tan,Yi Luo,Dingfang Pi et al.
Xianpei Tan et al.
Background: Alzheimer's disease (AD) is the most common neurodegenerative disease, and the accumulation of amyloid-β is the initial process in AD. MicroRNAs (miRNAs) are widely known as key regulators of the accumulation...
Propofol Pretreatment Prevents Oxygen-Glucose Deprivation/Reoxygenation (OGD/R)-induced Inflammation Through Nuclear Transcription Factor κB (NF-κB) Pathway in Neuroblastoma Cells [0.03%]
异丙酚预处理通过核转录因子κB途径防止神经母细胞瘤炎症反应
Fang Hu,Jianhua Jiang,Guocan Yu et al.
Fang Hu et al.
Background: Inflammation is one of the causes of neuroblastoma progression. Propofol attenuates inflammation by repressing nuclear transcription factor κB (NF-κB) in different diseases. But its effect on oxygen-glucose ...
Association Between Mean Platelet Volume and Hemorrhagic Transformation in Acute Ischemic Stroke Patients [0.03%]
急性缺血性卒中患者平均血小板体积与出血转化的关系
Changyi Wang,Lu Wang,Linghui Deng et al.
Changyi Wang et al.
Background: Hemorrhagic transformation (HT) is a frequent complication of acute ischemic stroke (AIS). Mean platelet volume (MPV) is a marker of platelet function. The relationship between MPV and HT remains unclear. ...
Differences in Post-ischemic Motor Recovery and Angiogenesis of MCAO Rats Following Electroacupuncture at Different Acupoints [0.03%]
不同针刺穴位对MCAO大鼠术后运动功能恢复及血管新生的影响研究
Li Liu,Qun Zhang,Hong-Yu Xie et al.
Li Liu et al.
Background: Electroacupuncture (EA) can promote nerve and vascular regeneration, confer neuroprotection, inhibit apoptosis and inflammatory reactions, reduce oxidative stress injury, regulate neurochemicals and inhibit th...
MicroRNA-451 Aggravates Kainic Acid-induced Seizure and Neuronal Apoptosis by Targeting GDNF [0.03%]
microRNA-451通过靶向GDNF加重氯化甲谷氨酸诱导的癫痫发作和神经元凋亡
Ning Weng,Jingbo Sun,Shixiang Kuang et al.
Ning Weng et al.
Aim: Epilepsy is a common and serious neurological disease that causes recurrent episodes, but its molecular mechanism remains unclear. Abnormal miRNA expression is associated with epilepsy, including miR-451. This resear...
TIMP-2 Polymorphisms Define Subtypes of Hypertensive Intracerebral Hemorrhage with Distinct Perihematomal Edema Development Patterns [0.03%]
TIMP-2基因多态性与高血压脑出血后红磁场发展模式相关
Ru Chen,Zhi Song,Mingzhu Deng et al.
Ru Chen et al.
Background: Perihematomal edema (PHE) is a major threat leading to poor functional outcomes after intracerebral hemorrhage (ICH). TIMP-2 is considered to participate in the formation of PHE after ICH by antagonizing the d...