Curcumin Attenuates Cerebral Ischemia-reperfusion Injury Through Regulating Mitophagy and Preserving Mitochondrial Function [0.03%]
姜黄素通过调节线粒体自噬和保护线粒体功能来缓解脑缺血再灌注损伤
Weiwei Wang,Jiaping Xu
Weiwei Wang
Background: Curcumin, the complex extracted from the traditional edible herb, has a wide range of pharmacological effects. A great deal of studies has demonstrated that curcumin could protect against cerebral ischemia-rep...
MiR-101 Attenuates Myocardial Infarction-induced Injury by Targeting DDIT4 to Regulate Autophagy [0.03%]
microRNA-101通过靶向DDIT4调节自噬从而减轻心肌梗死诱导的心脏损伤
Qiulan Li,Yanping Gao,Jie Zhu et al.
Qiulan Li et al.
Background: Myocardial Infarction (MI), a kind of heart deficiency, is the main cause of death and disability. Autophagy, a metabolic process for the degradation of damaged proteins or organelles, is important for cardiac...
Dexmedetomidine Pretreatment Improves Lipopolysaccharide-induced Iron Homeostasis Disorder in Aged Mice [0.03%]
Dexmedetomidine预处理改善脂多糖诱导的老年小鼠铁稳态紊乱
Fenghui Guo,Jinmeng Kang,Juntao Tan et al.
Fenghui Guo et al.
Background: Iron homeostasis disorder and neuroinflammation are the most commonly known factors that promote the occurrence and development of cognitive impairment in people. Dexmedetomidine has an anti-inflammatory effec...
Mesenchymal Stem Cell-derived Exosomes Rescue Oxygen-Glucose Deprivation-induced Injury in Endothelial Cells [0.03%]
间充质干细胞来源的外泌体对内皮细胞缺氧葡萄糖损伤的修复作用
Li-Yun Kong,Meng-Ya Liang,Jian-Ping Liu et al.
Li-Yun Kong et al.
Objective: The effects of mesenchymal stem cell (MSC)-derived exosomes on brain microvascular endothelial cells under oxygen-glucose deprivation (OGD), which mimic cells in deep hypothermic circulatory arrest (DHCA) in vi...
Isoflurane Preconditioning Protects the Myocardium Against Ischemia and Reperfusion Injury by Upregulating GRM1 Expression [0.03%]
异氟醚预处理通过上调GRM1表达保护心肌免受缺血再灌注损伤的影响
He Huang,Xiaoyan Qing,Handan Li
He Huang
Background: Reduction in myocardial I/R injury has become the key to the therapy of ischemic cardiovascular disease. Isoflurane (ISO) preconditioning can mimic the major potent protective mechanisms and attenuate ischemia...
Early Age of Migraine Onset is Independently Related to Cognitive Decline and Symptoms of Depression Affect Quality of Life [0.03%]
头痛早期发作与认知下降和抑郁症状影响生活质量独立相关
Jiajia Bao,Mengmeng Ma,Shuju Dong et al.
Jiajia Bao et al.
Background: People with migraine experience cognitive decline more often than healthy controls, resulting in a significant functional impact. Early identifying influencing factors that contribute to cognitive decline in m...
Nanocurcumin Inhibits Angiogenesis via Down-regulating hif1a/VEGF-A Signaling in Zebrafish [0.03%]
纳米姜黄素通过下调hif1a/VEGF-A信号抑制斑马鱼血管生成
Zigang Cao,Shicong He,Yuyang Peng et al.
Zigang Cao et al.
Background: Curcumin has anti-inflammatory, antioxidant and anticancer properties. Despite the considerable evidence showing that curcumin is an efficacious and safe compound for multiple medicinal benefits, there are som...
Association Between Preoperative Midline Shift Growing Rate and Outcomes of Decompressive Craniectomy in Patients with Malignant Middle Cerebral Artery Infarction [0.03%]
恶性大脑中动脉梗死患者减压术前纵裂池移位增长速度与预后的相关性研究
Ruozhen Yuan,Simiao Wu,Yajun Cheng et al.
Ruozhen Yuan et al.
Background: Whether preoperative midline shift and its growing rate are associated with outcomes of decompressive craniectomy in patients with malignant middle cerebral artery infarction is unknown. ...
MicroRNA-582-5p Reduces Propofol-induced Apoptosis in Developing Neurons by Targeting ROCK1 [0.03%]
microRNA-582-5p通过靶向ROCK1减少异氟醚致发育神经元凋亡
Zhongjie Zhang,Yan Xu,Songyuan Chi et al.
Zhongjie Zhang et al.
Background: Propofol is an intravenous drug commonly used in anesthesia procedures and intensive care in children. However, it also has neurotoxic effects on children. MicroRNA plays an important role in neurological dise...