MiR-485-5p Promotes Neuron Survival through Mediating Rac1/Notch2 Signaling Pathway after Cerebral Ischemia/Reperfusion [0.03%]
miR-485-5p通过介导Rac1/Notch2信号通路促进脑缺血再灌注后神经元存活
Xuan Chen,Sumei Zhang,Peipei Shi et al.
Xuan Chen et al.
Objective: Ischemia-reperfusion (I/R) injury is a pathological feature of ischemic stroke. This study investigated the regulatory role of miR-485-5p in I/R injury. ...
Pathogenic Mechanisms of a Stroke-like attack Elicited by Epidural Steroid Injection Therapy [0.03%]
硬膜外皮质类固醇注射诱发的类似中风发作的致病机制研究
Zhen He
Zhen He
Background: The pathogenic mechanisms involved in a disastrous scenario, following epidural steroid injections (ESI), remain unclarified. Intra-arterial injection of steroids with needlepenetrating vascular injury would b...
Pharmacological Inhibition of Transient Receptor Potential Melastatin 2 (TRPM2) Channels Attenuates Diabetes-induced Cognitive Deficits in Rats: A Mechanistic Study [0.03%]
药理学抑制瞬时受体电位锚蛋白2通道减轻大鼠糖尿病所致认知障碍：一种机制研究
Pavan Thapak,Mahendra Bishnoi,Shyam S Sharma
Pavan Thapak
Background: Diabetes is a chronic metabolic disorder affecting the central nervous system. A growing body of evidence has depicted that high glucose level leads to the activation of the transient receptor potential melast...
Overexpression of miR-26a-5p Suppresses Tau Phosphorylation and Aβ Accumulation in the Alzheimer's Disease Mice by Targeting DYRK1A [0.03%]
miR-26a-5p过表达通过靶向DYRK1A抑制阿尔茨海默病小鼠tau过度磷酸化和Aβ沉积
Yanni Liu,Lin Wang,Fuheng Xie et al.
Yanni Liu et al.
Objective: It is reported that miR-26a-5p could regulate neuronal development, but its underlying mechanisms in Alzheimer's disease (AD) progression is unclear. ...
Donepezil Improves Gait Performance in Patients with an Acute Cerebral Infarction: A Prospective Observational Cohort Study [0.03%]
多奈哌齐改善急性脑梗死患者的步态性能：前瞻性队列研究
Ying-Ying Lin,Shi-Jie Guo,Hui Quan et al.
Ying-Ying Lin et al.
Background: Hemiplegia is a common symptom after acute cerebral infarction. Objective: This study aimed to explore the influence factor...
Observational Study
Current neurovascular research. 2020;17(3):304-311. DOI:10.2174/1567202617666200413130101 2020
Riluzole Exhibits No Therapeutic Efficacy on a Transgenic Rat model of Amyotrophic Lateral Sclerosis [0.03%]
利鲁唑对肌萎缩侧索硬化转基因大鼠无效性研究
Si Chen,Qiao Liao,Ke Lu et al.
Si Chen et al.
Background: Amyotrophic lateral sclerosis (ALS) is a neurological disorder clinically characterized by motor system dysfunction, with intraneuronal accumulation of the TAR DNAbinding protein 43 (TDP-43) being a pathologic...
Dynamic Change of Neutrophil to Lymphocyte Ratios and Infection in Patients with Acute Ischemic Stroke [0.03%]
急性缺血性卒中患者中性粒细胞与淋巴细胞比值的动态变化及其感染状况
Lu Wang,Wen Guo,Changyi Wang et al.
Lu Wang et al.
Background: Neutrophil to lymphocyte ratio (NLR) on admission was reported to be a predictor of pneumonia after stroke. The aim of this study was to investigate the association between the temporal change of NLR and post-...
Kenneth Maiese
Kenneth Maiese
The prevalence of diabetes mellitus (DM) continues to increase throughout the world. In the United States (US) alone, approximately ten percent of the population is diagnosed with DM and another thirty-five percent of the population is cons...
Kenneth Maiese
Kenneth Maiese
Knockdown of miR-124 Reduces Depression-like Behavior by Targeting CREB1 and BDNF [0.03%]
miR-124敲低通过靶向CREB1和BDNF降低类似抑郁行为
Wei Yang,Min Liu,Qianwei Zhang et al.
Wei Yang et al.
Objective: As a brain-specific microRNA, the mechanism of miR-124 in depression has not been clarified so far. The present study aimed to explore the role of miR-124 in depression and its potential targets. ...