Brivaracetam Prevents the Over-expression of Synaptic Vesicle Protein 2A and Rescues the Deficits of Hippocampal Long-term Potentiation In Vivo in Chronic Temporal Lobe Epilepsy Rats [0.03%]
溴吡斯的明可防止慢性颞叶癫痫大鼠突触囊泡蛋白2A过度表达及改善海马长期 potentiation缺陷
Yu-Xing Ge,Ying-Ying Lin,Qian-Qian Bi et al.
Yu-Xing Ge et al.
Background: Patients with temporal lobe epilepsy (TLE) usually suffer from cognitive deficits and recurrent seizures. Brivaracetam (BRV) is a novel anti-epileptic drug (AEDs) recently used for the treatment of partial sei...
Association Between Coagulation Function and Spontaneous Hemorrhagic Transformation in Acute Ischemic Stroke [0.03%]
凝血功能与急性缺血性卒中自发性出血转化的相关性研究
Chen Ye,Yanan Wang,Quhong Song et al.
Chen Ye et al.
Background and purpose: Hemorrhagic transformation (HT) has an adverse effect on the prognosis of patients with acute ischemic stroke, and it is currently known associated with coagulation system. But the conclusion is no...
Involvement of the Sodium Channel Nav1.7 in Paclitaxel-induced Peripheral Neuropathy through ERK1/2 Signaling in Rats [0.03%]
钠通道Nav1.7通过ERK1/2信号通路介导紫杉醇外周神经毒性的作用机制研究
Guang Jie Wang,Xi Zhang,Li-De Huang et al.
Guang Jie Wang et al.
Background: Paclitaxel treatment is a major cause of chemotherapy-induced peripheral neuropathy. The sodium channel Nav1.7 plays a critical role in pain perception. However, whether Nav1.7 in the dorsal root ganglion (DRG...
Low-dose Sevoflurane Attenuates Cardiopulmonary Bypass (CPB)- induced Postoperative Cognitive Dysfunction (POCD) by Regulating Hippocampus Apoptosis via PI3K/AKT Pathway [0.03%]
低浓度七氟醚通过PI3K/AKT信号通路调节海马凋亡从而减轻体外循环术后认知功能障碍
Jianhua Qin,Qingjun Ma,Dongmei Ma
Jianhua Qin
Background: Cardiopulmonary bypass (CPB) caused postoperative cognitive dysfunction (POCD) was characterized by hippocampus apoptosis, which seriously limited the therapeutic efficacy and utilization of CPB in clinic. Rec...
Upregulation of miR-496 Rescues Propofol-induced Neurotoxicity by Targeting Rho Associated Coiled-coil Containing Protein Kinase 2 (ROCK2) in Prefrontal Cortical Neurons [0.03%]
miR-496上调通过靶向 ROCK2 抑制丙泊酚诱导的大鼠前额皮质神经元毒性损伤
Zemei Mao,Wanju Wang,Haixia Gong et al.
Zemei Mao et al.
Objective: Early exposure to general anesthesia in children might be a potentially highrisk factor for learning and behavioral disorders. The mechanism of neurotoxicity induced by general anesthesia was not defined. miR-4...
MicroR-26b Targets High Mobility Group, AT-hook 2 to Ameliorate Myocardial Infarction-induced Fibrosis by Suppression of Cardiac Fibroblasts Activation [0.03%]
微小RNA-26b通过靶向高移动性组AT-hook 2缓解心肌成纤维细胞活化和心梗后心肌纤维化恶化
Xiao Chen,Zhaosheng Ding,Tong Li et al.
Xiao Chen et al.
Background: Myocardial Fibrosis (MF) is an important physiological change after myocardial infarction (MI). MicroRNA-26b (MiR-26b) has a certain inhibitory effect on pulmonary fibrosis. However, the role of miR-26b in MI-...
The Mechanistic Target of Rapamycin (mTOR): Novel Considerations as an Antiviral Treatment [0.03%]
雷帕霉素靶点(mTOR)：作为抗病毒治疗的新考虑因素
Kenneth Maiese
Kenneth Maiese
Multiple viral pathogens can pose a significant health risk to individuals. As a recent example, the β-coronavirus family virion, SARS-CoV-2, has quickly evolved as a pandemic leading to coronavirus disease 2019 (COVID-19) and has been dec...
Determinants of Use of Long-term Continuous Electrocardiographic Monitoring for Acute Ischemic Stroke Patients without Atrial Fibrillation at Baseline [0.03%]
基线无房颤的急性缺血性卒中患者长期连续心电监测的影响因素分析
Jiann-Der Lee,Yen-Chu Huang,Meng Lee et al.
Jiann-Der Lee et al.
Background: Atrial fibrillation (AF) is the most common cardiac rhythm disorder associated with stroke. Increased risk of stroke is the same regardless of whether the AF is permanent or paroxysmal. However, detecting paro...
Multicenter Study
Current neurovascular research. 2020;17(3):224-231. DOI:10.2174/1567202617666200423092025 2020
Red Blood Cell Indices in Relation to Post-stroke Psychiatric Disorders: A Longitudinal Study in a Follow-up Stroke Clinic [0.03%]
与卒中后精神障碍相关的红细胞指数：随访卒中门诊的纵向研究
Haichao Wang,Li Gong,Xiaomei Xia et al.
Haichao Wang et al.
Background: Depression and anxiety after stroke are common conditions that are likely to be neglected. Abnormal red blood cell (RBC) indices may be associated with neuropsychiatric disorders. However, the association of R...
Mehmet Bostanciklioğlu
Mehmet Bostanciklioğlu
Memory retrieval is mediated by discharges of acetylcholine, glutamate, gammaaminobutyric acid, norepinephrine, and serotonin/5-hydroxytryptamine circuits. These projections and memory interact through engram circuits, neurobiological trace...